Thermo Scientific™

POROS™ CaptureSelect™ AAVX Affinity Resin

Catalog number: A36741
Thermo Scientific™

POROS™ CaptureSelect™ AAVX Affinity Resin

Catalog number: A36741
Catalog Number
A36741
Unit Size
50 mL
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10 mL
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25 mL
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250 mL
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1,000 mL
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5,000 mL
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10,000 mL
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Catalog NumberUnit SizePrice (USD)AvailabilityQuantity
A3674150 mL
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A3673910 mL
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A3674025 mL
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A36742250 mL
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A367431,000 mLContact Us ›--
A367445,000 mLContact Us ›--
A3674510,000 mLContact Us ›--
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POROS CaptureSelect AAVX Affinity Resin is engineered to address the high selectivity and capacity requirements for large-scale downstream purification of a broad range of naturally occurring and synthetic adeno-associated virus (AAV) serotypes used for gene therapy applications. POROS CaptureSelect AAVX resin has demonstrated binding reactivity towards a set of AAV serotypes that includes AAV1 to AAV8, and AAVrh10 as well as synthetic serotypes.

Features of POROS CaptureSelect AAVX resin include:

  • One-step AAV purification from crude material with high purity and yield
  • High specificity and capacity, maximizing yield by significantly reducing process steps
  • Superior capacity maintained at high flow rates
  • Excellent scalability and easier handling and packing due to rigid polymeric bead
  • Non-animal derived

POROS CaptureSelect AAVX Affinity Resin enables a robust, fast, and platformable purification process for wide-ranging AAV serotypes with excellent purity and yield obtained in one step. This resin comes with complete technical and regulatory support.

Main characteristics

  • Matrix: cross-linked poly(styrene-divinylbenzene) POROS beads
  • Average particle size: 50 μm
  • Ligand: CaptureSelect AAVX affinity ligand
  • Binding capacity: >1 x 1013 genome copies/mL of resin
  • Elution conditions: acidic elution with 0.1 M glycine, pH 3.0
  • Mechanical resistance: 100 bar (1450 psi; 10 MPa)
  • Formulation buffer: 18% (v/v) ethanol

Free of animal components

CaptureSelect products contain affinity ligands based on recombinant single-domain antibody fragments (VHH) created by a proprietary technology. The VHH affinity ligand is a 12 to 15 kDa fragment comprising the three complementarity-determining regions (CDRs) that form the antigen-binding domain, efficiently produced in the yeast Saccharomyces cerevisiae by a production process free of any animal components (Animal Origin-Free).

Specifications

Binding Capacity
>1 x 1013 genome copies/mL of resin
Shipping Condition
Wet Ice
Particle Size
50 μm
Form
Liquid Suspension
Product Line
POROS™
Quantity
50 mL
Type
Resin
Column Type
Affinity

Contents & Storage

Store in refrigerator at 2°C to 8°C.

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