Ethanol Alters DNMT1/3a/3b Expression Profile, Promotes Persistent DNA Hypomethylation in Human Brain Endothelial Cells and Impairs Late Cortical Angiogenesis.
Exposure of the embryonic central nervous system (CNS) to drugs of abuse, such as ethanol, induces severe and persistent damage to neural cells, contributing to the development of fetal alcohol spectrum disorders (FASD). Previously, using a mouse model of FASD, we showed that prenatal alcohol exposure (PAE) directly impairs blood–brain ... More
Generation of hiPSCs (JUCGRMi008-A) from a β-propeller protein-associated neurodegeneration patient with WDR45 mutation.
AuthorsKamikura R,Liu X,Ishikawa KI,Yoshino H,Hattori N,Akamatsu W
JournalStem cell research
PubMed ID42119323
Harnessing intermediate-scale bioreactors for next-generation macrophage production and application.
Macrophages are crucial in immune responses, tissue repair, homeostasis, making them prime candidates for translational applications. Induced pluripotent stem cell (iPSC) derived-macrophages hold significant promise for regenerative medicine, cancer therapy, inflammatory disease treatment and in vitro bioassays. However, cost-effective, standardized intermediate-scale bioreactor systems tailored for early-stage research and drug discovery ... More
ILC2s regulate a fibroblast progenitor niche in the pancreas.
Local fibroblast development and densities influence organ health and disease, although it remains unclear how tissue fibroblast topography is controlled in situ. Here we defined group 2 innate lymphoid cells (ILC2) as key regulators of fibroblast homeostasis in the pancreas. ILC2 co-localised with fibroblasts expressing the genes Pi16( )Dpp4( )Ly6c( ... More