Gibco™

CTS™ TrueCut™ Cas9 Protein

Catalog number: A45220
Gibco™

CTS™ TrueCut™ Cas9 Protein

Catalog number: A45220
Catalog Number
A45220
Unit Size
2.5 mg
Price (USD)
12,000.00
Your Price:
Quantity
Catalog Number
Unit Size
5.0 mg
Price (USD)
23,000.00
Your Price:
Quantity
Catalog NumberUnit SizePrice (USD)Quantity
A452202.5 mg
12,000.00
Your Price:
A452215.0 mg
23,000.00
Your Price:
Product Overview
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Gibco CTS TrueCut Cas9 Protein is our highest performing CRISPR-Cas9 protein, engineered to deliver maximum ribonucleoprotein (RNP)-editing efficiency. This protein is manufactured in compliance with standards for Ancillary Materials for Cell, Gene and Tissue-Based Products and is subjected to stringent quality specifications. It is provided in a high-concentration and large-scale format for process development and clinical research applications.

Features of CTS TrueCut Cas9 Protein include:
Consistent high editing efficiency—superior CRISPR-Cas9 editing efficiency in all tested cell lines including primary immune cells (>90% editing in primary T cells)
Higher stringency manufacturing—manufactured to meet the standards for Ancillary Materials for Cell, Gene, and Tissue-Based Products including USP <1043>, Ph.Eur. 5.2.12, and ISO 20399 -1, -2, -3, following the principles of 21 CFR Part 820 in a FDA-registered manufacturing site
Aseptic manufacturing—entire process completed using single-use technology
Extensive safety testing—includes sterility, endotoxin, mycoplasma, residual nucleic acids, and proteins
Sterile filling—finished product is vialed in a Class A/B (Class 100 and ISO 5 equivalents) cleanroom
Traceability documentation—COA, COO, Drug Master Files, and Regulatory Support Files are available

CTS TrueCut Cas9 Protein is a Streptococcus pyogenes Cas9 (wt) protein, produced by recombinant DNA technology in E. coli for genome editing with CRISPR technology. Cas9 protein forms a very stable RNP complex with the guide RNA (gRNA) component of the CRISPR/Cas9 system. Incorporation of NLS aids delivery to the nucleus, increasing the editing efficiency and on-target cleavage.

If you would like to evaluate our TrueCut Cas9 protein or conduct small-scale research experiments, we recommend using our TrueCut Cas9 Protein v2.

Specifications

Concentration
10 mg/mL
Shipping Condition
Dry Ice
Quantity
2.5 mg
Product Type
Cas9 Protein
Research Category
Genome Editing
Product Line
TrueCut™

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