Transforming growth factor ß signaling upregulates the expression of human GDP-fucose transporter by activating transcription factor Sp1.
AuthorsXu YX, Ma A, Liu L
Journal
PubMed ID24069312
'GDP-fucose transporter plays a crucial role in fucosylation of glycoproteins by providing activated fucose donor, GDP-fucose, for fucosyltransferases in the lumen of the Golgi apparatus. Fucose-containing glycans are involved in many biological processes, which are essential for growth and development. Mutations in the GDP-fucose transporter gene cause leukocyte adhesion deficiency ... More
Mechanotransduction is enhanced by the synergistic action of heterotypic cell interactions and TGF-ß1.
AuthorsYoussef J, Chen P, Shenoy VB, Morgan JR
JournalFASEB J
PubMed ID22375018
'With the use of planar substrates and collagen gels, the field of mechanotransduction has focused on the role of extracellular matrix stiffness, mechanical tension, and TGF-ß1 in generating a more contractile fibroblast. However, little is known about the role of cell-cell interactions in inducing cellular contraction. We used 3-dimensional self-assembled ... More
The anti-metastatic activity of collagenase-2 in breast cancer cells is mediated by a signaling pathway involving decorin and miR-21.
AuthorsSoria-Valles C, Gutiérrez-Fernández A, Guiu M, Mari B, Fueyo A, Gomis RR, López-Otín C
Journal
PubMed ID23851508
'Matrix metalloproteinases (MMPs) have been traditionally implicated in cancer progression because of their ability to degrade the extracellular matrix. However, some members of the MMP family have recently been identified as proteases with antitumor properties. Thus, it has been described that collagenase-2 (MMP-8) has a protective role in tumor and ... More
Dextran derivatives modulate collagen matrix organization in dermal equivalent.
'Dextran derivatives can protect heparin binding growth factor implied in wound healing, such as transforming growth factor-beta1 (TGF-beta1) and fibroblast growth factor-2 (FGF-2). The first aim of this study was to investigate the effect of these compounds on human dermal fibroblasts in culture with or without TGF-beta1. Several dextran derivatives ... More
Alpha-2 Heremans Schmid Glycoprotein (AHSG) modulates signaling pathways in head and neck squamous cell carcinoma cell line SQ20B.
AuthorsThompson PD, Sakwe A, Koumangoye R, Yarbrough WG, Ochieng J, Marshall DR
Journal
PubMed ID24332981
'This study was performed to identify the potential role of Alpha-2 Heremans Schmid Glycoprotein (AHSG) in Head and Neck Squamous Cell Carcinoma (HNSCC) tumorigenesis using an HNSCC cell line model. HNSCC cell lines are unique among cancer cell lines, in that they produce endogenous AHSG and do not rely, solely, ... More
Fibroblast growth factor-2 regulates human cardiac myofibroblast-mediated extracellular matrix remodeling.
AuthorsSvystonyuk DA, Ngu JM, Mewhort HE, Lipon BD, Teng G, Guzzardi DG, Malik G, Belke DD, Fedak PW
Journal
PubMed ID25948488
'Tissue fibrosis and chamber remodeling is a hallmark of the failing heart and the final common pathway for heart failure of diverse etiologies. Sustained elevation of pro-fibrotic cytokine transforming growth factor-beta1 (TGFß1) induces cardiac myofibroblast-mediated fibrosis and progressive structural tissue remodeling.' ... More
TGF-ß1 promotes motility and invasiveness of glioma cells through activation of ADAM17.
AuthorsLu Y, Jiang F, Zheng X, Katakowski M, Buller B, To SS, Chopp M
JournalOncol Rep
PubMed ID21359495
The transforming growth factor ß1 (TGF-ß1) belongs to a family of structurally related polypeptide factors. TGF-beta plays an important role in the pathobiology of invasion of malignant gliomas. The objective of the present study was to investigate the impact of TNF-a converting enzyme (TACE/ADAM17) signaling on the process of TGF-ß1-stimulated ... More
Disruption of E-cadherin by matrix metalloproteinase directly mediates epithelial-mesenchymal transition downstream of transforming growth factor-beta1 in renal tubular epithelial cells.
AuthorsZheng G, Lyons JG, Tan TK, Wang Y, Hsu TT, Min D, Succar L, Rangan GK, Hu M, Henderson BR, Alexander SI, Harris DC
JournalAm J Pathol
PubMed ID19590041
Epithelial-mesenchymal transition (EMT) plays an important role in organ fibrosis, including that of the kidney. Loss of E-cadherin expression is a hallmark of EMT; however, whether the loss of E-cadherin is a consequence or a cause of EMT remains unknown, especially in the renal system. In this study, we show ... More
Transforming growth factor-beta1 induces tissue inhibitor of metalloproteinase-1 expression via activation of extracellular signal-regulated kinase and Sp1 in human fibrosarcoma cells.
AuthorsKwak HJ, Park MJ, Cho H, Park CM, Moon SI, Lee HC, Park IC, Kim MS, Rhee CH, Hong SI
JournalMol Cancer Res
PubMed ID16547158
The net balance of matrix metalloproteinases (MMP) and tissue inhibitor of metalloproteinases (TIMP) system has been known to be a key factor in tumor cell invasion. In the present study, we investigated the molecular mechanisms of anti-invasive and antimigrative activity of transforming growth factor (TGF)-beta1 on HT1080 human fibrosarcoma cells. ... More