Anisakis pegreffii impacts differentiation and function of human dendritic cells.
AuthorsNapoletano C, Mattiucci S, Colantoni A, Battisti F, Zizzari IG, Rahimi H, Nuti M, Rughetti A
JournalParasite Immunol
PubMed ID29569735
'Human dendritic cells (DCs) show remarkable phenotypic changes when matured in the presence of helminth-derived products. These modifications frequently elicited a polarization towards Th2 cells and regulatory T cells thus contributing to immunological tolerance against these pathogens. In this study, the interaction between DCs and larvae of the zoonotic anisakid ... More
Characterization of Microvesicles in Septic Shock Using High-Sensitivity Flow Cytometry.
AuthorsLehner GF, Harler U, Haller VM, Feistritzer C, Hasslacher J, Dunzendorfer S, Bellmann R, Joannidis M
JournalShock
PubMed ID27206273
Endothelial pathology is considered to play a key role in septic shock. Since endothelial-derived microvesicles (MV) are elevated in various diseases associated with endothelial pathology, they are considered surrogate markers of the endothelial state. By analyzing the signature of circulating MV with high-sensitivity flow cytometry (hsFC), we wanted to test ... More
Myxoma Virus Optimizes Cisplatin for the Treatment of Ovarian Cancer In Vitro and in a Syngeneic Murine Dissemination Model.
AuthorsNounamo B, Liem J, Cannon M, Liu J
JournalMol Ther Oncolytics
PubMed ID28875159
A therapeutic approach to improve treatment outcome of ovarian cancer (OC) in patients is urgently needed. Myxoma virus (MYXV) is a candidate oncolytic virus that infects to eliminate OC cells. We found that in vitro MYXV treatment enhances cisplatin or gemcitabine treatment by allowing lower doses than the corresponding IC ... More
TK Inhibitor Pazopanib Primes DCs by Downregulation of the ß-Catenin Pathway.
AuthorsZizzari IG, Napoletano C, Botticelli A, Caponnetto S, Calabrò F, Gelibter A, Rughetti A, Ruscito I, Rahimi H, Rossi E, Schinzari G, Marchetti P, Nuti M
JournalCancer Immunol Res
PubMed ID29700053
Tyrosine kinase inhibitors (TKIs) target angiogenesis by affecting, for example, the VEGF receptors in tumors and have improved outcomes for patients with metastatic renal cell carcinoma (mRCC). Immune checkpoint inhibitors (ICIs) have also been proposed for treatment of mRCC with encouraging results. A better understanding of the activity of immune ... More
Platelet activity and hypercoagulation in type 2 diabetes.
AuthorsPretorius L, Thomson GJA, Adams RCM, Nell TA, Laubscher WA, Pretorius E
JournalCardiovasc Diabetol
PubMed ID30388964
A strong correlation exists between type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD), with CVD and the presence of atherosclerosis being the prevailing cause of morbidity and mortality in diabetic populations. T2DM is accompanied by various coagulopathies, including anomalous clot formation or amyloid fibrin(ogen), the presence of dysregulated inflammatory ... More
Parameters predicting COVID-19-induced myocardial injury and mortality.
AuthorsDuerr GD, Heine A, Hamiko M, Zimmer S, Luetkens JA, Nattermann J, Rieke G, Isaak A, Jehle J, Held SAE, Wasmuth JC, Wittmann M, Strassburg CP, Brossart P, Coburn M, Treede H, Nickenig G, Kurts C, Velten M
JournalLife Sci
PubMed ID32918975
Clinical manifestations of COVID-19 affect many organs, including the heart. Cardiovascular disease is a dominant comorbidity and prognostic factors predicting risk for critical courses are highly needed. Moreover, immunomechanisms underlying COVID-induced myocardial damage are poorly understood. ... More