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Thermo Scientific Chemicals
2,2-Difluoroacetophenone, 95%
CAS: 395-01-7 | C8H6F2O | 156.132 g/mol
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Catalog number H25750.03
also known as H25750-03
Price (USD)
187.65
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Quantity:
1 g
Price (USD)
187.65
Online Exclusive
208.00Save 20.35 (10%)
Each
Chemical Identifiers
CAS395-01-7
IUPAC Name2,2-difluoro-1-phenylethan-1-one
Molecular FormulaC8H6F2O
InChI KeyOLYKCPDTXVZOQF-UHFFFAOYSA-N
SMILESFC(F)C(=O)C1=CC=CC=C1
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Specifications
Specification Sheet
Specification SheetAppearance (Color)Clear colorless to pale yellow or pale pink
Assay (GC)≥94.0%
Refractive Index1.4950-1.5010 @ 20°C
Identification (FTIR)Conforms
FormLiquid
2,2-Difluoroacetophenone acts as an intermediate in the preparation of various substances such as pharmaceuticals. Further, it is used in the one-pot synthesis of difluoromethylated arenes from aryl chlorides and bromides. In addition to this, it undergoes reduction with (-)-diisopinocampheylchloroborane chloride to get R-alcohols of purity 85% ee.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
2,2-Difluoroacetophenone acts as an intermediate in the preparation of various substances such as pharmaceuticals. Further, it is used in the one-pot synthesis of difluoromethylated arenes from aryl chlorides and bromides. In addition to this, it undergoes reduction with (-)-diisopinocampheylchloroborane chloride to get R-alcohols of purity 85% ee.
Solubility
Immiscible with water.
Notes
Incompatible with strong oxidizing agents and strong acids.
2,2-Difluoroacetophenone acts as an intermediate in the preparation of various substances such as pharmaceuticals. Further, it is used in the one-pot synthesis of difluoromethylated arenes from aryl chlorides and bromides. In addition to this, it undergoes reduction with (-)-diisopinocampheylchloroborane chloride to get R-alcohols of purity 85% ee.
Solubility
Immiscible with water.
Notes
Incompatible with strong oxidizing agents and strong acids.
RUO – Research Use Only
General References:
- Kitamura, T.; Muta, K.; Muta, K. Hypervalent Iodine-Promoted alpha-Fluorination of Acetophenone Derivatives with a Triethylamine·HF Complex. J. Org. Chem. 2014, 79 (12), 5842-5846.
- Dudzik, A.; Snoch, W.; Borowiecki, P.; Opalinska-Piskorz, J.; Witko, M.; Heider, J.; Szaleniec, M. Asymmetric reduction of ketones and beta-keto esters by (S)-1-phenylethanol dehydrogenase from denitrifying bacterium Aromatoleum aromaticum. Appl. Microbiol. Biotechnol. 2014, 99 (12), 5055-5069.