Gibco™

Human Suspension Hepatocytes, Polymorphic Donors, (9-12 x 106 cells)

Catalog number:  HMCSPL

Related applications:

Pharma & Biopharma

| Primary Cell Culture

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Description

Each lot of cryopreserved human hepatocytes is suitable for use in suspension metabolism applications and has been pharmacogenetically characterized as an homozygous null allele (e.g. CYP2D6*4⁄*4) via genotyping analysis (TaqMan®). The commonly tested Phase I (P450) and Phase II (UGT, SULT) drug metabolizing enzymes are analyzed for metabolic activity in each lot. Metabolite formation is measured by standard biochemical assays using LC-MS/MS or HPLC.

Cells per vial: 9-12 million

Get the Results You Need with GIBCO® Hepatocytes
High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro/in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.

Each lot is tested for:

•Phase I and II enzyme activities
•Proper morphology
•Viabilities generally >75%

For research use only. Not intended for human or animal therapeutic or diagnostic use.

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Note:
These products require shipment in LN2 vapor dewars therefore additional fees may apply.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Cell Passage Number: Passage 0
Culture Type: Suspension Cell Culture
Donor Source: Single Donor
Form: Cryopreserved
No. of Cells: 9-12 x 106
Product Line: Gibco®
Species: Human
Cell Type: Hepatocytes
Format: Tube(s)

Contents & storage

Vials of cryopreserved hepatocytes should be stored in a cryostorage dewar or -135°C freezer.