Q Exactive™ Hybrid Quadrupole-Orbitrap™ Mass Spectrometer

      Q Exactive™ Hybrid Quadrupole-Orbitrap™ Mass Spectrometer

      Thermo Scientific™  Related applications: Industrial Mass Spectrometry

      Identify, quantify and confirm more compounds rapidly and with confidence using the Thermo Scientific™ Q Exactive™ Hybrid Quadrupole-Orbitrap Mass Spectrometer. This benchtop LC-MS/MS system combines quadruple precursor ion selection with high-resolution, accurate-mass (HRAM) Orbitrap detection to deliver exceptional performance and versatility. The Q Exactive Mass Spectrometer is equally useful for untargeted or targeted screening and a broad range of qualitative and quantitative applications in drug discovery, proteomics, environmental and food safety, clinical research and forensic toxicology.
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      Description

      High-Confidence Results, Quickly
      • HRAM and full-scan capabilities capture all sample data, all the time, enabling retrospective data analysis without need to re-run samples
      • Resolving power up to 140,000 FWHM eliminates isobaric interferences, increasing confidence in results when analyzing samples in complex matrices
      • Better than 1ppm mass accuracy in full-scan and all-ion fragmentation (AIF) modes ensures confident compound identification
      • Fast scanning at 12hz and spectral multiplexing suited to UHPLC applications
      • Rapid polarity switching maximizes information obtained
      • AIF and multiple dissociation techniques—in-source CID and HCD—aid in compound identification
      • Extended mass range to 6,000m/z enhances detection of singly charged small molecules and biomolecules
      • More than four orders of magnitude intrascan dynamic range, along with femtogram-level sensitivity, allow detection of trace-level and high-abundance compounds in the same scan

      Greater Confidence for Drug Discovery and Metabolism Studies

      • Triple quadruple-equivalent ability to quantify parent compounds and metabolites along with identity confirmation provides greater throughput
      • Fast HRAM Orbitrap technology eliminates interferences for high-confidence metabolite structural identification and large-scale profiling of metabolomics and lipidomics samples
      • Fast scan-to-scan polarity switching in both MS and MS/MS modes maximizes metabolite detection and identification from a single injection

      More Information for Superior Proteomics

      • HCD yields superior fragmentation and higher-quality MS/MS spectra compared to CID, improving identifications
      • High spectral quality and a wide dynamic range make it possible to identify and quantify proteins other instruments cannot find.
      • Quan/qual capability make it easier to transition from proteomic discovery experiments to targeted protein quantification

      Highly Specific Environmental and Food Safety Analyses

      • Specificity exceeding triple quadruple Q-TOF or Q-Trap levels make this mass spectrometer the preferred quan/qual screening platform
      • Data-dependent, full-scan MS/MS capabilities and HRAM data ensure the highest possible confidence in every identification

      High-Confidence Quanfirmation for Clinical Research and Forensic Toxicology

      • The combination of SRM and HRAM capabilities provides high-confidence quanfirmation of endogenous steroids, drugs of abuse and pain-management therapeutics with ease.

      Application-Specific Software for Greater Throughput

      • Thermo Scientific™ ExactFinder™, LCQuan™, Mass Frontier™, MetQuest™, MetWorks™, SIEVE™ and TraceFinder™ software are available to speed data analysis.

      To keep pace with the increasing demands of a modern laboratory, you need innovative solutions that give you more for your money. Can your Q-TOF? If not, consider the alternatives.



      New Clinical Research and Forensic Toxicology Application Compendium

      Discover the state of the art in LC-MS analysis for clinical research, drug monitoring research, forensic toxicology, sports anti-doping, and translational research.

      Download the compendium

      Documents

      Manuals & protocols