Thermo Scientific™

GC IsoLink™ II IRMS System

Thermo Scientific™

GC IsoLink™ II IRMS System


By combining the separation power of gas chromatography with IRMS, the Thermo Scientific™ GC IsoLink™ II IRMS System provides high sensitivity and precision for isotope analysis of individual organic compounds.

The GC IsoLink II conversion unit continuously and quantitatively converts all organic compounds eluting from a GC column into simple gases (CO₂, N₂, H₂, and CO) for high-precision IRMS analysis. It is built on holistic capillary design principles that maintain high resolution and enable maximal separation of constituent components of complex mixtures. With a proprietary modular design and plug-and-play injectors and detectors of the Thermo Scientific™ TRACE™ 1610 Gas Chromatograph, you can explore a multitude of configurations on the same GC system to meet the analytical challenges of today’s rapidly expanding isotope ratio applications.

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GC IsoLink II IRMS System highlights

  • Unique and fully automated combustion and high-temperature conversion unit for compound-specific analysis of 13C, 15N, 18O, and 2H
  • Sharp peak shape and higher sensitivity by true capillary design
  • The ultimate level of performance and versatility in GC-IRMS, including the hyphenation with a quadrupole MS
  • Driven by Thermo Scientific™ Qtegra™ ISDS Software


Boost laboratory efficiency
The TRACE 1610 GC is the latest technological breakthrough conceived to maximize uptime and profitability. The TRACE 1610 GC features user-installable, plug-in Thermo Scientific™ iConnect™ Injector and Detector Modules, enabling easy cable- and tubing-free connections.

  • Easily adapt the GC system configuration to your needs in minutes without special tools or training requirements with iConnect injector and detector modules
  • Simplified troubleshooting operations through quick replacement of iConnect injector and detector modules, without the need for service calls
  • Make capillary column installation quick and safe through tool-free Thermo Scientific™ iConnect Column Lock connectors
  • Enhance operability by using the multi-functional icon-based touch screen ideal for local instrument control and method development
  • Reduce operational costs with a GC system that allows the use of standard consumables
  • Save energy with low thermal mass and a quick start-up


Combustion and High Temperature Conversion in parallel
The GC IsoLink II System offers a fully automated switch between the combustion and the High Temperature Conversion as the two heaters are mounted in parallel. Dead volume-free switching technology is driven by the Qtegra ISDS Software, ensuring that the optimal conditions of the reactor in standby are maintained without any loss in the GC-IRMS sensitivity.

  • The combustion reactor (operating at 1,000 °C) provides optimal reactor conditions for achieving both complete oxidation and reduction, allowing the use of a single reactor for quantitative 13C and 15N analysis
  • Quantitative high-temperature conversion at 1,420 °C is applied for hydrogen analysis and at 1,280 °C for oxygen isotope analysis


Capillary reactor design and connectivity
The capillary design of the reactors maintains high resolution and enables maximal separation of constituent components of complex mixtures. A deactivated capillary is attached to the reactors with a capillary solder joint, eliminating any risk of leakage at reactor entrance. The reactors supplied with the instrument can be easily connected with the Micro Channel Device (MCD), an all-metal-sealed GC connection with Ag-ferrules allow high-temperature GC applications. The MCD is easy to install and already leak-free when finger-tight. No wrench required.


Sample injection flexibility
The GC IsoLink II IRMS System can be operated using automation capabilities of Thermo Scientific™ TriPlus™ RSH SMART Autosampler or Thermo Scientific™ AI/AS 1610 Liquid Autosampler.

  • The TriPlus RSH SMART Autosampler offers exceptional precision, flexibility, and productivity in robotic sample-handling solutions
  • The AI/AS 1610 Liquid Autosampler is the best quality-to-price solution for budget-conscious laboratories performing high throughput and QA/QC analysis


Simultaneous GC-MS and IRMS acquisition: GC-MS-IRMS
Hyphenated GC-IRMS/quadrupole MS allows simultaneous high-performance isotope ratio analysis, structural information, and identification of individual GC compounds from a single injection. The connection of a Thermo Scientific quadrupole MS to the TRACE 1610 GC in the GC IsoLink II System can be easily achieved by using the standard GC-MS transfer line. The choice of quadrupole MS systems, which couple to GC IsoLink II IRMS System includes:

  • Thermo Scientific™ ISQ™ 7610 Single Quadrupole GC-MS Systems
  • Thermo Scientific™ TSQ™ 9610 Triple Quadrupole GC-MS/MS Systems
  • Thermo Scientific™ Orbitrap™ Exploris™ GC 240 MS System


Smart workflows driven by Qtegra ISDS Software
The GC IsoLink II IRMS System is driven by Qtegra ISDS Software, featuring integration with Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS) capabilities. The layered approach for data visualization, online data evaluation and tailored data reports offers full control and confidence from sample to result.

Specifications, terms, and pricing are subject to change. Not all products are available in all countries. Please consult your local sales representative for details.


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