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Tyrphostin A23, 99%, Thermo Scientific Chemicals
Catalog number: J60308.MA
10 mg, Each
Thermo Scientific Chemicals
Tyrphostin A23, 99%, Thermo Scientific Chemicals
Catalog number: J60308.MA
10 mg, Each
Quantity
Catalog number: J60308.MA
also known as J60308-MA
Price (USD)
126.65 Online price
146.00
Each
Quantity
-
Chemical Identifiers
CAS
118409-57-7
IUPAC Name
2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile
Molecular Formula
C10H6N2O2
InChI Key
VTJXFTPMFYAJJU-UHFFFAOYSA-N
SMILES
OC1=CC=C(C=C(C#N)C#N)C=C1O
Specifications
Specification SheetAssay (HPLC)
>98.5%
Description
Tyrphostin inhibit protein tyrosine kinase and block the EGF-dependent autophosphorylation of the receptor. The inhibitors can bind to the EGF receptor kinase domain with different affinities. It also inhibits PDGFR kinase. Tyrphostin A23 has been used to inhibit agonist-induced GP IIb- IIIa activation in permeabilized platelets and in other studies to block calcium channel currents in vascular smooth muscle cells. . Tyrphostin A23 can also inhibit the internalization of (125)I-transferrin in Heb7a cells.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Tyrphostin inhibit protein tyrosine kinase and block the EGF-dependent autophosphorylation of the receptor. The inhibitors can bind to the EGF receptor kinase domain with different affinities. It also inhibits PDGFR kinase. Tyrphostin A23 has been used to inhibit agonist-induced GP IIb- IIIa activation in permeabilized platelets and in other studies to block calcium channel currents in vascular smooth muscle cells. . Tyrphostin A23 can also inhibit the internalization of (125)I-transferrin in Heb7a cells.
Solubility
Soluble in DMSO, ethanol, or DMF
Notes
Store in cool, dry place in a tightly sealed container. Store away from oxidizing agents, acids, heat.
Tyrphostin inhibit protein tyrosine kinase and block the EGF-dependent autophosphorylation of the receptor. The inhibitors can bind to the EGF receptor kinase domain with different affinities. It also inhibits PDGFR kinase. Tyrphostin A23 has been used to inhibit agonist-induced GP IIb- IIIa activation in permeabilized platelets and in other studies to block calcium channel currents in vascular smooth muscle cells. . Tyrphostin A23 can also inhibit the internalization of (125)I-transferrin in Heb7a cells.
Solubility
Soluble in DMSO, ethanol, or DMF
Notes
Store in cool, dry place in a tightly sealed container. Store away from oxidizing agents, acids, heat.
RUO – Research Use Only
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