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Thermo Scientific Chemicals
Bestatin hydrochloride, 98%, Thermo Scientific Chemicals
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Catalog number J60384.LB0
also known as J60384-#0
Price (USD)
93.65
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104.00Save 10.35 (10%)
Each
Quantity:
5 mg
Price (USD)
93.65
Online Exclusive
104.00Save 10.35 (10%)
Each
Chemical Identifiers
CAS65391-42-6
IUPAC Namehydrogen (2R,4S,5R)-2,5-diamino-4-hydroxy-2-(2-methylpropyl)-3-oxo-6-phenylhexanoic acid chloride
Molecular FormulaC16H25ClN2O4
InChI KeyJQOATSUOLWQWKR-KHUBKBNHSA-N
SMILES[H+].[Cl-].CC(C)C[C@](N)(C(O)=O)C(=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1
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Specification SheetBestatin is an inhibitor of amino peptidases and a potent, irreversible inhibitor of LTA4 hydrolase. It inhibits the amino peptidase activity of LTA4 hydrolase with a Ki value of 201 nM. It offers promise as a novel analgesic because it protects endogenous opioid peptides against degradation. It does not inhibit carboxypeptidases.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Bestatin is an inhibitor of amino peptidases and a potent, irreversible inhibitor of LTA4 hydrolase. It inhibits the amino peptidase activity of LTA4 hydrolase with a Ki value of 201 nM. It offers promise as a novel analgesic because it protects endogenous opioid peptides against degradation. It does not inhibit carboxypeptidases.
Solubility
Soluble in water (4 mg/ml, warm), DMSO (>25 mg/ml), methanol, acetic acid, dimethyl formamide, and 100% ethanol.
Notes
Store in cool, dry place in a tightly sealed container. Store away from oxidizing agents.
Bestatin is an inhibitor of amino peptidases and a potent, irreversible inhibitor of LTA4 hydrolase. It inhibits the amino peptidase activity of LTA4 hydrolase with a Ki value of 201 nM. It offers promise as a novel analgesic because it protects endogenous opioid peptides against degradation. It does not inhibit carboxypeptidases.
Solubility
Soluble in water (4 mg/ml, warm), DMSO (>25 mg/ml), methanol, acetic acid, dimethyl formamide, and 100% ethanol.
Notes
Store in cool, dry place in a tightly sealed container. Store away from oxidizing agents.
RUO – Research Use Only
General References:
- Mei-Rong Jia; Tao Wei; Wen-Fang Xu. The Analgesic Activity of Bestatin as a Potent APN Inhibitor. Frontiers in Neuroscience.2010, 4, 50.
- Donald L Gardiner; Katharine R Trenholme; Tina S Skinner-Adams; Colin M Stack; John P Dalton. Overexpression of leucyl aminopeptidase in Plasmodium falciparum parasites. Target for the antimalarial activity of bestatin. Journal of Biological Chemistry. 2006, 281 (3), 1741-1745.