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Colistin sulfate, Thermo Scientific Chemicals
Catalog number: J60915.03
1 g, Each
Thermo Scientific Chemicals
Colistin sulfate, Thermo Scientific Chemicals
Catalog number: J60915.03
1 g, Each
Quantity
Catalog number: J60915.03
also known as J60915-03
Price (USD)
Special offer:
143.65 169.00 Save 25.35 (14%)
Ends: 15-Oct-2024
Each
Quantity
-
Chemical Identifiers
CAS
1264-72-8
IUPAC Name
N-[(1S)-3-amino-1-{[(1S,2R)-1-{[(1S)-3-amino-1-{[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl]carbamoyl}-2-hydroxypropyl]carbamoyl}propyl]-6-methyloctanamide; sulfuric acid
Molecular Formula
C53H102N16O17S
InChI Key
ZJIWRHLZXQPFAD-LRYSGCCDSA-N
SMILES
OS(O)(=O)=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)[C@@H](C)O
Specifications
Specification SheetPotency
≥19000 IU/mg (dried basis)
Form
Powder
Appearance (Color)
White to pale cream
pH
4.0-6.0
Solution Test
Clear and light yellow solution (50 mg/ml in H2O)
Description
Colistin sulfate A Polymyxin potent antibiotic and apoptosis inducer. This compound induces apoptosis through interaction with the cytoplasmic membrane. Colistin is a key microbiological component in Colistin Oxolinic Acid Blood Agar utilized in the cultivation of Aminobacter aminovorans, Bacillus species, Hyphomicrobium species and Methylobacterium species. It is also a critical component is VCN Inhibitor & VCNT Inhibitor growth media used in the isolation of Neisseria species.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General description
• Colistin Sulfate salt is a stable, cationic, water-soluble, white powder composed of over 30 components
• Originally isolated from B. polymyxa, it inhibits the growth of the Gram-negative (e.g. E. coli, P. aeruginosa, P. fluorescens, and S. enterica), and Gram-positive bacteria (e.g. L. lactis, P. polymyxa, P. acidilactici, and S. aureus) by permeabilizing the bacterial cell membrane
Applications
• Colistin Sulfate has potent anti-endotoxin activity rendered through its ability to bind lippopolysaccharides that make up bacterial endotoxins
• This compound is often used in the management of multi-drug resistant Gram-negative infections
RUO – Research Use Only
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