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Thermo Scientific Chemicals
Leupeptin Hemisulfate
Reversible protease inhibitor which inhibits cathepsin B, calpain and trypsin | CAS: 103476-89-7 | C20H39N6O4+
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Catalog number J61188.MB
also known as J61188-MB
Price (USD)
192.65
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214.00Save 21.35 (10%)
Each
Quantity:
25 mg
Price (USD)
192.65
Online Exclusive
214.00Save 21.35 (10%)
Each
Chemical Identifiers
CAS103476-89-7
IUPAC Name[amino({[(4S)-4-[(2S)-2-[(2S)-2-acetamido-4-methylpentanamido]-4-methylpentanamido]-5-oxopentyl]amino})methylidene]azanium
Molecular FormulaC20H39N6O4
InChI KeyGDBQQVLCIARPGH-ULQDDVLXSA-O
SMILESCC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=[NH2+])C=O
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Specifications
Specification Sheet
Specification SheetAppearance (Color)White
FormPowder
Assay (HPLC)≥96.5%
Assay (special)Peptide content: ≥85.0%
Reversible protease inhibitor, which inhibits cathepsin B, calpain and trypsinPharmaceutical composition containing leupeptin hemisulfate is used as an anti-malarial agent. It is employed in the treatment of noise-induced hearing loss. It also protects the heart from myocardial stunning. Further, it is used to inhibit serine, cysteine proteases, plasmin, trypsin, papain, kallikrein and cathepsin B.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Reversible protease inhibitor, which inhibits cathepsin B, calpain and trypsinPharmaceutical composition containing leupeptin hemisulfate is used as an anti-malarial agent. It is employed in the treatment of noise-induced hearing loss. It also protects the heart from myocardial stunning. Further, it is used to inhibit serine, cysteine proteases, plasmin, trypsin, papain, kallikrein and cathepsin B.
Solubility
Soluble in water, ethanol, dimethyl formamide and acetic acid.
Notes
Store in a cool place. Incompatible with strong acids and strong bases.
Reversible protease inhibitor, which inhibits cathepsin B, calpain and trypsinPharmaceutical composition containing leupeptin hemisulfate is used as an anti-malarial agent. It is employed in the treatment of noise-induced hearing loss. It also protects the heart from myocardial stunning. Further, it is used to inhibit serine, cysteine proteases, plasmin, trypsin, papain, kallikrein and cathepsin B.
Solubility
Soluble in water, ethanol, dimethyl formamide and acetic acid.
Notes
Store in a cool place. Incompatible with strong acids and strong bases.
RUO – Research Use Only
General References:
- Uchikawa, S.; Yoda, M.; Tohmonda, T.; Kanaji, A.; Matsumoto, M.; Toyama, Y.; Horiuchi, K. ADAM17 regulates IL-1 signaling by selectively releasing IL-1 receptor type 2 from the cell surface. Cytokine 2015, 71 (2), 238-245.
- Solter, P. F.; Oyama, M. A.; Machen, M. C.; Trafny, D. J.; Sisson, D. D. Detection by ELISA of C-terminal proBNP in plasma from cats with cardiomyopathy. Vet. J. 2015, 206 (2), 213-217.
Contents & Storage
-30°C to -10°C