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Thermo Scientific Chemicals
Berberine chloride
CAS: 633-65-8 | C20H18ClNO4 | 371.817 g/mol
| Catalog Number | Quantity |
|---|---|
| J62311.06 also known as J62311-06 | 5 g |
Catalog number J62311.06
also known as J62311-06
Price (USD)
55.30
Each
Quantity:
5 g
Price (USD)
55.30
Each
Chemical Identifiers
CAS633-65-8
IUPAC Name16,17-dimethoxy-5,7-dioxa-13λ⁵-azapentacyclo[11.8.0.0²,¹⁰.0⁴,⁸.0¹⁵,²⁰]henicosa-1(21),2,4(8),9,13,15,17,19-octaen-13-ylium chloride
Molecular FormulaC20H18ClNO4
InChI KeyVKJGBAJNNALVAV-UHFFFAOYSA-M
SMILES[Cl-].COC1=CC=C2C=C3C4=CC5=C(OCO5)C=C4CC[N+]3=CC2=C1OC
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Specifications
Specification Sheet
Specification SheetAppearance (Color)Yellow to orange
Assay from Supplier's CofA≥88.0%
FormPowder
Berberine is an isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme Cox-2 (cyclooxygenase-2) which is abundantly expressed in colon cancer cells. Also inhibits c-Jun (Activator Protein 1), a transcription factor that plays a critical role in inflammation and carcinogenesis. Berberine upregulates the expression of Pgp in hepatoma cells. Treatment with berberine potentially results in the reduced accumulation of chemotherapeutic drugs.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Solubility
Soluble in dimethyl sulfoxide (74 mg/ml at 25°C), ethanol (<1mg/mL at 25°C), water (<1mg/mL at 25°C), and methanol.
Notes
Store at -20°C. Incompatible with oxidizing agents. Protect from heat.
Soluble in dimethyl sulfoxide (74 mg/ml at 25°C), ethanol (<1mg/mL at 25°C), water (<1mg/mL at 25°C), and methanol.
Notes
Store at -20°C. Incompatible with oxidizing agents. Protect from heat.
RUO – Research Use Only
Shrinivas K. Kulkarni.; Ashish Dhir. Possible involvement of l-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling pathway in the antidepressant activity of berberine chloride. Eur. J. Pharmacol. 2007, 569 (1-2),77-83 .