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Bacitracin
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Bacitracin
Bacitracin
Bacitracin
Thermo Scientific Chemicals

Bacitracin

Bacitracin, CAS # 1405-87-4, is cyclic polypeptide-based antibiotic which exhibits activity against microbes causing pneumonia, skin, and eye infections. | CAS: 1405-87-4 | C66H103N17O16S
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25 g
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Catalog number J62432.14
also known as J62432-14
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212.00
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Quantity:
25 g
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Price (USD)
212.00
Each
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Chemical Identifiers
CAS1405-87-4
IUPAC Name4-(2-{[2-(1-amino-2-methylbutyl)-4,5-dihydro-1,3-thiazol-4-yl]formamido}-4-methylpentanamido)-4-[(1-{[18-(3-aminopropyl)-12-benzyl-15-(butan-2-yl)-3-(carbamoylmethyl)-6-(carboxymethyl)-9-[(4H-imidazol-4-yl)methyl]-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclopentacosan-21-yl]carbamoyl}-2-methylbutyl)carbamoyl]butanoic acid zinc
Molecular FormulaC66H103N17O16SZn
InChI KeyQSNOBVJFKSQBBD-UHFFFAOYNA-N
SMILES[Zn].CCC(C)C(N)C1=NC(CS1)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(C(C)CC)C(=O)NC1CCCCNC(=O)C(CC(N)=O)NC(=O)C(CC(O)=O)NC(=O)C(CC2C=NC=N2)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(NC(=O)C(CCCN)NC1=O)C(C)CC
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SpecificationsSpecification SheetSpecification Sheet
Assay from Supplier's CofABacitracin A: ≥40.0%
Appearance (Color)White to pale cream
FormPowder
Assay from Supplier's CofAEarly Eluting Peptides (C1, C2, C3): ≤20.0%
Assay from Supplier's CofASum of Bacitracin A, B1, B2, B3: ≥70.0%
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This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Bacitracin is a mixture of at least nine different cyclic polypeptides, originally isolated from Bacillus bacteria in 1945
  • Bacitracins work by binding divalent metal cations and preventing the hydrolysis of lipids into usable cell wall components

Applications

  • Bacitracin has been paired with nanoparticles in some laboratory studies to increase its effectivity
  • It is suitable for the laboratory study of bacterial resistance, infection, and cross-reactivity
RUO – Research Use Only

General References:

  1. Tay, W.M.; Epperson, J.D.; da Silva, G.F.; Ming, L.J. 1H NMR, mechanism, and mononuclear oxidative activity of the antibiotic metallopeptide bacitracin: the role of D-Glu-4, interaction with pyrophosphate moiety, DNA binding and cleavage, and bioactivity. J Am Chem Soc. 2010, 28, 132(16), 5652-61.
  2. Karala, A.R.; Ruddock, L.W. Bacitracin is not a specific inhibitor of protein disulfide isomerase. FEBS J. 2010, 277(11), 2454-62.