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This product is animal origin and can only be shipped within the United States
Aprotinin, from Bovine Lung
Thermo Scientific Chemicals

Aprotinin, from Bovine Lung

Aprotinin (iniprol, CAS # 9087-70-1) is a single polypeptide chain from bovine tissues with antifibrinolytic activities.
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Catalog number J63039.MB
also known as J63039-MB
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Quantity:
25mg
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Chemical Identifiers
CAS9087-70-1
SpecificationsSpecification SheetSpecification Sheet
Appearance (Color)White to cream
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A potent protease inhibitor.Aprotinin acts as a reversible serine protease blocking and a binding agent. It is widely employed as an inhibitor of trypsin. It is also used as a proteolytic inhibitor in radioimmunoassays of polypeptide hormones. It is involved in the purification of urokinase, trypsin, and chymotrypsin on immobilized aprotinin. Further, it is used in the quantification of kallikrein activity in mixtures of esterases and proteases.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Aprotinin is a 58-amino acid polypeptide chain found in lung tissue

• Aprotinin can suppress the systemic inflammatory response by reversibly inhibiting various esterases and proteases; it acts as a broad spectrum serine protease inhibitor

Application

• Aprotinin can be used as an enzyme inhibitor in laboratory studies on chymotrypsin, kallikrein, plasmin, and others

• Aprotinin is useful for the laboratory study of post-operative bleeding and wound healing

RUO – Research Use Only

General References:

  1. Parvatikar A, Vacaliuc GS, Ramanathan A, Chennubhotla SC. ANCA: Anharmonic Conformational Analysis of Biomolecular Simulations. Biophys J. 2018 May 8;114(9):2040-2043. doi: 10.1016/j.bpj.2018.03.021. PMID: 29742397; PMCID: PMC5961460.
  2. Deloge E, Amour J, Provenchère S, Rozec B, Scherrer B, Ouattara A. Aprotinin vs. tranexamic acid in isolated coronary artery bypass surgery: A multicentre observational study. Eur J Anaesthesiol. 2017 May;34(5):280-287. doi: 10.1097/EJA.0000000000000604. PMID: 28221207.