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Geldanamycin, 98+%, Thermo Scientific Chemicals
Catalog number: J63397.MB
25 mg, Each
Thermo Scientific Chemicals
Geldanamycin, 98+%, Thermo Scientific Chemicals
Catalog number: J63397.MB
25 mg, Each
Quantity
Catalog number: J63397.MB
also known as J63397-MB
Price (USD)
Price: 200.00
Your price:
Quantity
-
Chemical Identifiers
CAS
30562-34-6
IUPAC Name
13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
Molecular Formula
C29H40N2O9
InChI Key
QTQAWLPCGQOSGP-UHFFFAOYNA-N
SMILES
COC1CC(C)CC2=C(OC)C(=O)C=C(NC(=O)C(C)=CC=CC(OC)C(OC(N)=O)C(C)=CC(C)C1O)C2=O
Specifications
Specification SheetAssay from Supplier's CofA
>98.0% (HPLC)
Form
Powder or crystals or crystalline powder
Appearance (Color)
Yellow
Description
Geldanamycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins. It interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Geldanamycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins. It interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.
Solubility
Soluble in dimethyl sulfoxide at 100 mg/mL.
Notes
Store in a cool dry place. Keep away from oxidizing agents. Protect from heat.
Geldanamycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins. It interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.
Solubility
Soluble in dimethyl sulfoxide at 100 mg/mL.
Notes
Store in a cool dry place. Keep away from oxidizing agents. Protect from heat.
RUO – Research Use Only
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