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G418 disulfate, 50mg/ml solution
G418 disulfate, 50mg/ml solution
G418 disulfate, 50mg/ml solution
Thermo Scientific Chemicals

G418 disulfate, 50mg/ml solution

G418 sulfate, geneticin, CAS # 108321-42-2, is an antibiotic closely related to Gentamicin B, the common aminoglycoside antibiotic. | CAS: 108321-42-2 | C20H44N4O18S2 | 692.70 g/mol
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Catalog number J63871.AD
also known as J63871-AD
Price (USD)
421.65
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468.00
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Quantity:
50 mL
Request bulk or custom format
Price (USD)
421.65
Online Exclusive
468.00
Save 46.35 (10%)
Each
Chemical Identifiers
CAS108321-42-2
IUPAC Name(2R,3S,4R,5R,6S)-5-amino-6-{[(1R,2S,3S,4R,6S)-4,6-diamino-3-{[(2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-2-(1-hydroxyethyl)oxane-3,4-diol; bis(sulfuric acid)
Molecular FormulaC20H44N4O18S2
InChI KeyUHEPSJJJMTWUCP-KETIWVBHNA-N
SMILESOS(O)(=O)=O.OS(O)(=O)=O.CN[C@@H]1[C@@H](O)[C@@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H](C(C)O)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)OC[C@]1(C)O
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SpecificationsSpecification SheetSpecification Sheet
Appearance (Color)Clear colorless
AbsorbanceA570 nm: ≤0.10
Potency≥700 µg/mg
FormLiquid
Absorbanceat 280 nm: ≤0.015
G418 disulfate is used for selection and maintenance of prokaryotic and eukaryotic cells transfected with a iNOS promoter construct and neomycin resistance gene. Optimal concentrations for selection and maintenance vary by cell lines.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • G418 sulfate (geneticin) is an aminoglycoside antibiotic isolated from Micromonospora rhodorangea
  • G418 is bacteriostatic that prevents polypeptide formation by inhibiting the elongation step of polypeptide synthesis

Applications

  • G418 sulfate can be used for the selection of genetically engineered cells in both eukaryotes and prokaryotes
  • Laboratory-grade for applications such as biochemistry
RUO – Research Use Only

General References:

  1. Arshad, H.; Patel, Z.; Mehrabian, M.; Bourkas, M.; Al-Azzawi, Z.; Schmitt-Ulms, G., & Watts, J. C. 2021. The aminoglycoside G418 hinders de novo prion infection in cultured cells. The Journal of biological chemistry, 297(3), 101073.
  2. Ferguson, M. W.; Gerak, C.; Chow, C.; Rastelli, E. J.; Elmore, K. E.; Stahl, F.; Hosseini-Farahabadi, S.; Baradaran-Heravi, A.; Coltart, D. M., & Roberge, M. 2019. The antimalarial drug mefloquine enhances TP53 premature termination codon readthrough by aminoglycoside G418. PloS one, 14(5), e0216423.