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Thermo Scientific Chemicals
Tamibarotene
A retinoic acid receptor → (RAR→) agonist | CAS: 94497-51-5 | C22H25NO3 | 351.45 g/mol
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Catalog number J64028.MF
also known as J64028-MF
Price (USD)
515.65
Special offer
Online exclusive
Ends: 30-Jun-2026
607.00Save 91.35 (15%)
Each
Quantity:
50 mg
Price (USD)
515.65
Special offer
Online exclusive
Ends: 30-Jun-2026
607.00Save 91.35 (15%)
Each
Specifications
CAS94497-51-5
ChEBICHEBI:32181
Chemical Name or MaterialTamibarotene
ColorWhite
Formula Weight351.44
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Tamibarotene is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 ?M respectively).
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Tamibarotene is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 μM respectively).
Solubility
Soluble to 50 mM in DMSO
Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents.
Tamibarotene is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 μM respectively).
Solubility
Soluble to 50 mM in DMSO
Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents.
RUO – Research Use Only
General References:
- B.A.Bernard; J.M.Bernardon; C.Delescluse; B.Martin; M.C.Lenoir; J.Maignan; B.Charpentier; W.R.Pilgrim; U.Reichert; B.Shroot. Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor gamma. Biochem Biophys Res Commun. 1992, 186,(2), 977-983.
- Shiro Jimi; Kota Mashima; Taichi Matsumoto; Shuji Hara; Junji Suzumiya; Kazuo Tamura. RARα is a regulatory factor for Am-80-induced cell growth inhibition of hematologic malignant cells. International Journal of Oncology. 2007, 31,(2), 397-404.