Orexin is a neuropeptide that modulates the energy and metabolism balance. The effects of orexin are mediated by one of the two G protein-coupled receptors, orexin receptor 1 or 2. OXRs are expressed in oxinergic projection areas of the brain and regulate food intake by reducing systemic and brain signals that drive over-eating. Synthetic peptide corresponding to the C-terminus of human orexin receptor 1, conjugated to KLH. The immunizing peptide has 70% homology with the rat and mouse gene.

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