Structure Search

Thermo Scientific Chemicals

Sodium hydroxide, flake, 98%

Azithromycin dihydrate, CAS # 117772-70-0, is an azalide derived from erythromycin that shows antibacterial activity. | CAS: 117772-70-0 | C38H76N2O14 | 785.026 g/mol

Catalog Number	Quantity
J66740.06 also known as J66740-06	5 g

This chemical may require us to obtain additional information for our regulatory and chemical compliance records. If required, we will contact you for this information once your order is placed.

Catalog number J66740.06

also known as J66740-06

Price (USD)

315.65

Online exclusive

350.00

Save 34.35

Quantity:

Request bulk or custom format

Price (USD)

315.65

Online exclusive

350.00

Save 34.35

Chemical Identifiers

CAS117772-70-0

IUPAC Name(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-2-ethyl-3,4,10-trihydroxy-13-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one dihydrate

Molecular FormulaC38H76N2O14

InChI KeySRMPHJKQVUDLQE-KUJJYQHYSA-N

SMILESO.O.CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O

Specifications

Assay (unspecified)945 ?g/mg min.

FormPowder

Optical Rotation-45? to -49?

Appearance (Color)White to off-white

Water Content (Karl Fischer Titration)4.0-5.0%

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Suitable for battery materials development.

General Description

• Azithromycin dihydrate is the dihydrate form of azithromycin, an azalide derived from erythromycin, that shows antibacterial activity

• Azithromycin dihydrate reversibly binds to the 23S rRNA of the 50S ribosomal subunit of the bacterial ribosome of susceptible microorganisms, inhibiting the translocation step of protein synthesis by preventing the assembly of the 50S ribosomal subunit. This inhibits bacterial protein synthesis and cell growth, causing cell death

Application

• Azithromycin dihydrate shows anti-immunomodulatory and anti-inflammatory activities

• It shows antimalarial activity against Plasmodium falciparum and P. vivax, which are multidrug-resistant species

• In the laboratory, azithromycin dihydrate has been used in blocking buffer for indirect immunofluorescence

• It has been used in U87 cells for cell viability assay and flow cytometry analysis to study the Zika virus infection in glial cells

• Azithromycin dihydrate has been used in experiments to compare its antibacterial activity with PYRRO-C3D against Streptococcus pneumoniae biofilms

RUO – Research Use Only

General References:

Retallack H, Di Lullo E, Arias C, Knopp KA, Laurie MT, Sandoval-Espinosa C, Mancia Leon WR, Krencik R, Ullian EM, Spatazza J, Pollen AA, Mandel-Brehm C, Nowakowski TJ, Kriegstein AR, DeRisi JL. Zika virus cell tropism in the developing human brain and inhibition by azithromycin. Proc Natl Acad Sci U S A. 2016, 113, (50), 14408-14413.
Allan RN, Kelso MJ, Rineh A, Yepuri NR, Feelisch M, Soren O, Brito-Mutunayagam S, Salib RJ, Stoodley P, Clarke SC, Webb JS, Hall-Stoodley L, Faust SN. Cephalosporin-NO-donor prodrug PYRRO-C3D shows β-lactam-mediated activity against Streptococcus pneumoniae biofilms. Nitric Oxide. 2017 May 1;65:43-49.
Keiko Yamauchi; Yoko Shibata; Tomomi Kimura; Shuichi Abe; Sumito Inoue; Daisuke Osaka; Michiko Sato; Akira Igarashi; Isao Kubota. Azithromycin suppresses interleukin-12p40 expression in lipopolysaccharide and interferon-gamma stimulated macrophages. International Journal of Biological Sciences.2009, 5, (7), 667-678.