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Bafilomycin A1, 0.1 mg/ml in DMSO, sterile-filtered
Bafilomycin A1, 0.1 mg/ml in DMSO, sterile-filtered
Bafilomycin A1, 0.1 mg/ml in DMSO, sterile-filtered
Thermo Scientific Chemicals

Bafilomycin A1, 0.1 mg/ml in DMSO, sterile-filtered

Bafilomycin A1, CAS # 88899-55-2, is an inhibitor of vacuolar ATPases from Streptomyces griseus that has antibacterial, antifungal, and antineoplastic activity. | CAS: 88899-55-2 | C35H58O9 | 622.84 g/mol
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Catalog NumberQuantity
J67193.XF
also known as J67193-XF
1 mL
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Catalog number J67193.XF
also known as J67193-XF
Price (USD)
425.65
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Online exclusive
Ends: 30-Jun-2026
501.00
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Quantity:
1 mL
Request bulk or custom format
Price (USD)
425.65
Special offer
Online exclusive
Ends: 30-Jun-2026
501.00
Save 75.35 (15%)
Each
Chemical Identifiers
CAS88899-55-2
IUPAC Name(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-[(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-dihydroxy-5-methyl-6-(propan-2-yl)oxan-2-yl]-3-hydroxypentan-2-yl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-1-oxacyclohexadeca-3,5,11,13-tetraen-2-one
Molecular FormulaC35H58O9
InChI KeyXDHNQDDQEHDUTM-JQWOJBOSSA-N
SMILESCO[C@H]1\C=C\C=C(C)\C[C@H](C)[C@H](O)[C@H](C)\C=C(/C)\C=C(OC)\C(=O)O[C@@H]1[C@@H](C)[C@@H](O)[C@H](C)[C@@]1(O)C[C@@H](O)[C@H](C)[C@H](O1)C(C)C
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SpecificationsSpecification SheetSpecification Sheet
CommentDissolved in DMSO under sterile conditons.
FormLiquid
Appearance (Color)Pale yellow
Bafilomycin A1 is a potent and selective inhibitor of V-ATPase (vacuolar-type H+ ATPase). The compound can inhibit E1E2 ATPases from sarcoplasmic reticulum, Escherichia coli, and ox brain versus F1F0 ATPases found in bacteria and mitochondria. Some of the more bafilomycin A1 affected ATPases include Neurospora and plant vacuoles, as well as chromaffin granules. Additionally, Bafilomycin A1 prevents lysosomal cholesterol trafficking in macrophages and can be used to distinguish different types of ATPases. Research shows that Bafilomycin A1 can inhibit macroautophagy and promote apoptosis in colon cancer cells.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Bafilomycin A1 is a specific potent inhibitor of vacuolar ATPases
  • It is a macrolide antibiotic, and shows fungicide activity

Application

  • Bafilomycin A1 has antibacterial, antifungal, and antineoplastic activity
  • It can be immunosuppressive
  • It can prevent maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes
  • It is a potent and selective inhibitor of vacuolar-type H+ ATPase (V-ATPase)
RUO – Research Use Only

General References:

  1. Miao, Y.; Li, G.; Zhang, X.; Xu, H.; Abraham, S. N. A TRP Channel Senses Lysosome Neutralization by Pathogens to Trigger Their Expulsion. Cell. 2015, 161 (6), 1306-1319.
  2. Lee, K. I.; Kim, M. J.; Koh, H.; Lee, J. I.; Namkoong, S.; Oh, W. K.; Park, J.The anti-hypertensive drug reserpine induces neuronal cell death through inhibition of autophagic flux. Biochem. Biophys. Res. Commun. 2015, 462 (4), 402-408.