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Puromycin dihydrochloride, 10 mg/ml in distilled water, sterile-filtered
Puromycin dihydrochloride, 10 mg/ml in distilled water, sterile-filtered
Puromycin dihydrochloride, 10 mg/ml in distilled water, sterile-filtered
Thermo Scientific Chemicals

Puromycin dihydrochloride, 10 mg/ml in distilled water, sterile-filtered

Puromycin (puromycine, CAS # 58-58-2) is a bacteriostatic antibiotic that acts as an aminoacyl-tRNA analog and disrupts protein synthesis. | CAS: 58-58-2 | C22H31Cl2N7O5 | 544.43 g/mol
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1 mL
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Catalog number J67236.8EQ
also known as J67236-8=
Price (USD)
252.65
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280.00
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Quantity:
5 x 1 mL
Request bulk or custom format
Price (USD)
252.65
Online Exclusive
280.00
Save 27.35 (10%)
Each
Chemical Identifiers
CAS53-79-2
IUPAC Name(2S)-2-amino-N-[(2S,4R,5R)-5-[6-(dimethylamino)-9H-purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide
Molecular FormulaC22H29N7O5
InChI KeyRXWNCPJZOCPEPQ-WABMVTPESA-N
SMILESCOC1=CC=C(C[C@H](N)C(=O)NC2[C@@H](CO)O[C@H]([C@@H]2O)N2C=NC3=C(N=CN=C23)N(C)C)C=C1
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SpecificationsSpecification SheetSpecification Sheet
Appearance (Color)Clear colorless to pale cream
Assay (special)Absorbance at 275nm (0.1mg/ml): 0.28 to 0.38
pH6.0 to 7.0
FormLiquid
Assay (special)Bacterial endotoxin: ≤5.0 EU/mg
Puromycin is also used as a substrate of Mdr-1. It is been widely used in cell culture applications. It also induces apoptosis which was found as parallel apoptosis caused by deprivation of neuronal growth factor (NGF) in developing chick sympathetic neurons; however, this apoptotic activity can be inhibited by several transcriptional inhibitors such as: actinomycin D and α-amanitin (sc-202440) which has lead researchers to hypothesize that apoptosis is triggered through the transcription of particular genes. Shown to arrest cells in G2/M phase. Puromycin is an inhibitor of CD13 and DPP7.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Puromycin (puromycine) is an aminoglycoside antibiotic originating from Streptomyces alboniger
  • It acts as an aminoacyl tRNA analog and prematurely terminates peptide elongation
  • Puromycin has effects on both prokaryotes and eukaryotes
  • Puromycin may also have neoplastic activity

Application

  • Puromycin can be used for research use as an immunofluorescent target, in antibiotic resistance testing, or for studies on drug mechanisms
RUO – Research Use Only