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Mitomycin C, 5 mg/ml in DMSO, sterile-filtered
Mitomycin C, 5 mg/ml in DMSO, sterile-filtered
Mitomycin C, 5 mg/ml in DMSO, sterile-filtered
Thermo Scientific Chemicals

Mitomycin C, 5 mg/ml in DMSO, sterile-filtered

Mitomycin C, CAS # 50-07-7, is a methylazirinopyrroloindoledione complex isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. It is a versatile and potent compound with antibiotic activity and may have potential therapeutic value in the treatment of cancer. | CAS: 50-07-7 | C15H18N4O5 | 334.332 g/mol
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Catalog NumberQuantity
J67460.XF
also known as J67460-XF
1 mL
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Catalog number J67460.XF
also known as J67460-XF
Price (USD)
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Quantity:
1 mL
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Chemical Identifiers
CAS50-07-7
IUPAC Name[(4S,6S,7R,8S)-11-amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.0²,⁷.0⁴,⁶]trideca-1(9),11-dien-8-yl]methyl carbamate
Molecular FormulaC15H18N4O5
InChI KeyNWIBSHFKIJFRCO-WUDYKRTCSA-N
SMILESCO[C@]12[C@H]3N[C@H]3CN1C1=C([C@H]2COC(N)=O)C(=O)C(N)=C(C)C1=O
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SpecificationsSpecification SheetSpecification Sheet
FormLiquid
CommentMitomycin C: 5 mg/mL
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Mitomycin C is a water-soluble, blue-violet crystalline powder, unstable in light and acidic conditions, but maybe stably stored at 2-8°c
  • Bio-reduced mitomycin C generates oxygen radicals, alkylates DNA, and produces inter-strand DNA cross-links, thereby inhibiting DNA synthesis

Applications

  • Mitomycin C is preferentially toxic to hypoxic cells that are resistant to cancer therapy, and is therefore used to study its potential therapeutic effect on advanced stages of cancer
  • At high concentrations, mitomycin C inhibits RNA and protein synthesis and demonstrates strong antibiotic properties towards both Gram-positive and Gram-negative bacteria
WARNING: Cancer – www.P65Warnings.ca.gov
RUO – Research Use Only

General References:

  1. Verweij, J.; Pinedo, H. M. Mitomycin C: mechanism of action, usefulness and limitations. Anticancer Drugs. 1990, 1(1), 5-13.
  2. Tomasz, M.; Mitomycin, C. Small, fast and deadly (but very selective). Chem Biol. 1995, 2(9), 575-9.
  3. Teus, M. A.; de Benito-Llopis, L.; Alió, J.L. Mitomycin C in corneal refractive surgery. Surv Ophthalmol. 2009 Jul-Aug;54(4):487-502.