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Thermo Scientific™

GeneBLAzer™ ADORA2A-CRE-bla CHO-K1 Cells

Catalog number:  K1530

Related applications:

Pharma & Biopharma

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Description

GeneBLAzer® ADORA2A-CRE-bla CHO-K1 cells contain the human Adenosine Receptor A2A (ADORA2A) stably integrated into the CellSensor® CRE-bla CHO-K1 cell line. CellSensor® CRE-bla CHO-K1 cells (Cat. no. K1535) contain a beta-lactamase reporter gene under control of the Cyclic AMP Response Element (CRE) response element.

The GeneBLAzer® ADORA2A-CRE-bla CHO-K1 cells are functionally validated for Z' and EC50 concentrations of NECA. In addition, GeneBLAzer® ADORA2A-CRE-bla CHO-K1 cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.

ADORA2A has been shown to have many roles throughout the body. ADORA2A is involved in pain and inflammation regulation, inhibition of platelet aggregation, blood pressure regulation and contributes to ischemic brain damage. Selective antagonists of the ADORA2A pathway are being tested as adjuvants to dopaminergic drugs to treat Parkinson's disease and schizophrenia.

For Academic pricing please login or contact us at discoverysciences@invitrogen.com.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number: NM_000675
Assay Entry: Cell-based beta lactamase reporter gene
Cell Line: CHO-K1
Cell State: Dividing Cells
Detection Method: Fluorescent
Druggable Target: GPCRs
Gene Symbol: ADORA2A
Population Status: Single Cell Clone Origin
Product Line: GeneBLAzer®
Reporter Gene: BLA (Beta-Lactamase)
System Type: GeneBLAzer™
Target Entry: ADORA2A
Technique: FRET

Contents & storage

Contents:
K1530 GeneBLAzer® ADORA2A-CRE-bla CHO-K1 cells
(LiveBLAzer™-FRET B⁄G Loading Kit, Solution D and other materials are required separately; please refer to the protocol).
Includes:
• GeneBLAzer® ADORA2A-CRE-bla CHO-K1 cells
• GeneBLAzer® ADORA2A-CRE-bla CHO-K1
• Certificate of Analysis

Storage:
The GeneBLAzer® ADORA2A-CRE-bla CHO-K1 cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt.