GeneBLAzer™ MC5R-CRE-bla CHO-K1 cells contain the human Melanocortin Receptor 5 (MC5R) stably integrated into the CellSensor™ CRE-bla CHO-K1 cell line. CellSensor™ CRE-bla CHO-K1 cells (Cat. no. K1535) contain a beta-lactamase reporter gene under control of the Cyclic AMP Response Element (CRE) response element.
The GeneBLAzer™ MC5R-CRE-bla CHO-K1 cells are functionally validated for Z' and EC50 concentrations of NPD-α MSH In addition, GeneBLAzer™ MC5R-CRE-bla CHO-K1 cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.
MC5R is expressed in skin, muscle, lung, liver, spleen, and adrenal tissue. MC5R is Gs-coupled and binds all of the melanocortin peptides and ACTH. A recent study suggests that MC5R is involved in fat storage in the sebocyte cells of the skin. Another study in mice links MC5R to aggressive behavior. Mice deficient in MC5R acted less aggressively when treated with alpha-MSH.
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For Research Use Only. Not for use in diagnostic procedures.
Cell-based beta lactamase reporter gene
For Use With (Application)
Single Cell Clone Origin
Contents & Storage
Contents: K1740 GeneBLAzer™ MC5R-CRE-bla CHO-K1 cells (LiveBLAzer™-FRET B⁄G Loading Kit, Solution D and other materials are required separately; please refer to the protocol). Includes: • GeneBLAzer™ MC5R-CRE-bla CHO-K1 cells • GeneBLAzer™ MC5R-CRE-bla CHO-K1 Assay Protocol • Certificate of Analysis
Storage: The GeneBLAzer™ MC5R-CRE-bla CHO-K1 cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt.