During checkout, this product may be reported as "Out of Stock" with an Estimated Availability date. The Actual Availability date for this product may be earlier. Send inquiries regarding Actual Availability date, including the catalog number, to firstname.lastname@example.org.
The Tango™ MTNR1B-bla U2OS cells contain the human Melatonin Receptor 1B (MTNR1B) linked to a TEV protease site and a Gal4-VP16 transcription factor stably integrated into the Tango™ GPCR-bla U2OS parental cell line. This parental cell line stably expresses a beta-arrestin⁄TEV protease fusion protein and the beta-lactamase (bla) reporter gene under the control of a UAS response element.
The Tango™ MTNR1B-bla U2OS cells cells have been functionally validated for Z' factor and EC50 concentrations of established ligands. In addition, Tango™ MTNR1B-bla U2OS cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary for each product.
For Research Use Only. Not for use in diagnostic procedures.
Cell-based beta-arrestin recruitment
Tail from AVPR2 GPCR
Pool of Stable Cells
Contents & Storage
K1753 Tango™ MTNR1B-bla U2OS cells (LiveBLAzer™-FRET B⁄G Loading Kit, Solution D and other materials are required separately; please refer to the protocol). Includes: • Tango™ MTNR1B-bla U2OS cells • Tango™ MTNR1B-bla U2OS Assay Protocol • Certificate of Analysis
Storage: The Tango™ MTNR1B-bla U2OS cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt.