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Tango™ MCHR2-bla U2OS Cells

Catalog number: K1836

 Related applications: Target & Lead Identification & Validation

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Description

The Tango™ MCHR2-bla U2OS cells contain the human Melanin-concentrating hormone receptor 2 (MCHR2) linked to a TEV protease site and a Gal4-VP16 transcription factor stably integrated into the Tango™ GPCR-bla U2OS parental cell line. This parental cell line stably expresses a beta-arrestin⁄TEV protease fusion protein and the beta-lactamase (bla) reporter gene under the control of a UAS response element.

The Tango™ MCHR2-bla U2OS cells are functionally validated for Z' and EC50 concentrations of I-TAC (CXCL11). In addition, Tango™ MCHR2-bla U2OS cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.

For Academic pricing please login or contact us at discoverysciences@invitrogen.com.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

System: Tango™
Readout: End Point
Cell Line: U2OS
Technique: FRET
Cell State: Dividing Cells
Gene Symbol: MCHR2
Product Size: 8 x 106 cells
Accession Number: NM_032503.2
Cytoplasmic Tail: Tail from AVPR2 GPCR
Detection Method: Fluorescent
Druggable Target: GPCRs
Population Status: Single Cell Clone Origin
Shipping Condition: Room Temperature

Contents & storage

Contents:
K1836 Tango™ MCHR2-bla U2OS cells
(LiveBLAzer™-FRET B⁄G Loading Kit, Solution D and other materials are required separately; please refer to the protocol).
Includes:
• Tango™ MCHR2-bla U2OS cells
• Tango™ MCHR2-bla U2OS Assay Protocol
• Certificate of Analysis

Storage:
The Tango™ MCHR2-bla U2OS cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt.

Documents

Manuals & protocols