The a disintegrin and metalloproteinase (ADAM)-17 releases pro-inflammatory cytokines, including tumor necrosis factor-α, and several epidermal growth factor receptor ligands from cells. ADAM17 is post-translationally regulated by the inactive rhomboid pseudoproteases iRhom1 and iRhom2, and dysregulation of this signaling axis contributes to diseases ranging from chronic inflammation to cancer. Here, ... More
No evidence of persisting measles virus in peripheral blood mononuclear cells from children with autism spectrum disorder.
AuthorsD'Souza Y, Fombonne E, Ward BJ,
JournalPediatrics
PubMed ID17015560
'OBJECTIVES: Despite epidemiologic evidence to the contrary, claims of an association between measles-mumps-rubella vaccination and the development of autism have persisted. Such claims are based primarily on the identification of measles virus nucleic acids in tissues and body fluids by polymerase chain reaction. We sought to determine whether measles virus ... More
Evidence of antibiotic resistance gene silencing in Escherichia coli.
AuthorsEnne VI, Delsol AA, Roe JM, Bennett PM,
JournalAntimicrob Agents Chemother
PubMed ID16940095
The possibility that unexpressed antibiotic resistance genes are carried by bacterial genomes is seldom investigated. Potential silencing of the resistance genes bla(OXA-2), aadA1, sul1, and tetA carried on the plasmid pVE46 in a recent porcine isolate of Escherichia coli was investigated following oral inoculation of the strain into organic piglets. ... More
Role of LRAT on the retinoid isomerase activity and membrane association of Rpe65.
AuthorsJin M, Yuan Q, Li S, Travis GH,
JournalJ Biol Chem
PubMed ID17504753
Absorption of a photon by a vertebrate opsin pigment induces 11-cis to all-trans isomerization of its retinaldehyde chromophore. Restoration of light sensitivity to the bleached opsin requires chemical re-isomerization of the chromophore via an enzyme pathway called the visual cycle. The retinoid isomerase in this pathway is Rpe65, a membrane-associated ... More