The a disintegrin and metalloproteinase (ADAM)-17 releases pro-inflammatory cytokines, including tumor necrosis factor-α, and several epidermal growth factor receptor ligands from cells. ADAM17 is post-translationally regulated by the inactive rhomboid pseudoproteases iRhom1 and iRhom2, and dysregulation of this signaling axis contributes to diseases ranging from chronic inflammation to cancer. Here, ... More
Role of LRAT on the retinoid isomerase activity and membrane association of Rpe65.
AuthorsJin M, Yuan Q, Li S, Travis GH,
JournalJ Biol Chem
PubMed ID17504753
Absorption of a photon by a vertebrate opsin pigment induces 11-cis to all-trans isomerization of its retinaldehyde chromophore. Restoration of light sensitivity to the bleached opsin requires chemical re-isomerization of the chromophore via an enzyme pathway called the visual cycle. The retinoid isomerase in this pathway is Rpe65, a membrane-associated ... More