N-terminal processing is essential for release of epithin, a mouse type II membrane serine protease.
Authors Cho E G; Kim M G; Kim C; Kim S R; Seong I S; Chung C; Schwartz R H; Park D;
JournalJ Biol Chem
PubMed ID11567025
'Epithin was originally identified as a mouse type II membrane serine protease. Its human orthologue membrane type-serine protease 1 (MT-SP1)/matriptase has been reported to be localized on the plasma membrane. In addition, soluble forms of matriptase were isolated from human breast milk and breast cancer cell-conditioned medium. In this paper, ... More
Adenoviral expression of vascular endothelial growth factor-C induces lymphangiogenesis in the skin.
Authors Enholm B; Karpanen T; Jeltsch M; Kubo H; Stenback F; Prevo R; Jackson D G; Yla-Herttuala S; Alitalo K;
JournalCirc Res
PubMed ID11282897
'The growth of blood and lymphatic vasculature is mediated in part by secreted polypeptides of the vascular endothelial growth factor (VEGF) family. The prototype VEGF binds VEGF receptor (VEGFR)-1 and VEGFR-2 and is angiogenic, whereas VEGF-C, which binds to VEGFR-2 and VEGFR-3, is either angiogenic or lymphangiogenic in different assays. ... More
Bifocal is a downstream target of the Ste20-like serine/threonine kinase misshapen in regulating photoreceptor growth cone targeting in Drosophila.
AuthorsRuan W, Long H, Vuong DH, Rao Y,
JournalNeuron
PubMed ID12467587
'Misshapen (Msn) has been proposed to shut down Drosophila photoreceptor (R cell) growth cone motility in response to targeting signals linked by the SH2/SH3 adaptor protein Dock. Here, we show that Bifocal (Bif), a putative cytoskeletal regulator, is a component of the Msn pathway for regulating R cell growth cone ... More
Interactions of bovine viral diarrhoea virus glycoprotein E(rns) with cell surface glycosaminoglycans.
Authors Iqbal M; Flick-Smith H; McCauley J W;
JournalJ Gen Virol
PubMed ID10644844
'Recombinant E(rns) glycoprotein of bovine viral diarrhoea virus (BVDV) has been tagged with a marker epitope or linked to an immunoglobulin Fc tail and expressed in insect and mammalian cell lines. The product was shown to be functional, both having ribonuclease activity and binding to a variety of cells that ... More
Urokinase-derived peptides regulate vascular smooth muscle contraction in vitro and in vivo.
Authors Haj-Yehia A; Nassar T; Sachais B S; Kuo A; Bdeir K; Al-Mehdi A B; Mazar A; Cines D B; Higazi A A;
JournalFASEB J
PubMed ID10877834
'We examined the effect of urokinase (uPA) and its fragments on vascular smooth muscle cell contraction. Single-chain uPA inhibits phenylepherine (PE) -induced contraction of rat aortic rings, whereas two-chain uPA exerts the opposite effect. Two independent epitopes mediating these opposing activities were identified. A6, a capped peptide corresponding to amino ... More
C-mannosylation and O-fucosylation of the thrombospondin type 1 module.
Authors Hofsteenge J; Huwiler K G; Macek B; Hess D; Lawler J; Mosher D F; Peter-Katalinic J;
JournalJ Biol Chem
PubMed ID11067851
Thrombospondin-1 (TSP-1) is a multidomain protein that has been implicated in cell adhesion, motility, and growth. Some of these functions have been localized to the three thrombospondin type 1 repeats (TSRs), modules of approximately 60 amino acids in length with conserved Cys and Trp residues. The Trp residues occur in ... More