Interaction of intracellular beta amyloid peptide with chaperone proteins.
Authors Fonte Virginia; Kapulkin Vadim; Taft Andrew; Fluet Amy; Friedman David; Link Christopher D;
JournalProc Natl Acad Sci U S A
PubMed ID12089340
'Expression of the human beta amyloid peptide (A beta) in transgenic Caenorhabditis elegans animals can lead to the formation of intracellular immunoreactive deposits as well as the formation of intracellular amyloid. We have used this model to identify proteins that interact with intracellular A beta in vivo. Mass spectrometry analysis ... More
Human Trp3 forms both inositol trisphosphate receptor-dependent and receptor-independent store-operated cation channels in DT40 avian B lymphocytes.
Authors Vazquez G; Lievremont J P; St J Bird G; Putney J W Jr;
JournalProc Natl Acad Sci U S A
PubMed ID11553786
'Mammalian Trp proteins are candidates for plasma membrane calcium channels regulated by receptor activation or by intracellular calcium store depletion [capacitative calcium entry (CCE)]. One extensively investigated member of the Trp family, the human Trp3 (hTrp3), behaves as a receptor-activated, calcium-permeable, nonselective cation channel when expressed in cell lines and ... More