Structure and ligand of a histone acetyltransferase bromodomain.
AuthorsDhalluin C, Carlson JE, Zeng L, He C, Aggarwal AK, Zhou MM
JournalNature
PubMed ID10365964
Histone acetylation is important in chromatin remodelling and gene activation. Nearly all known histone-acetyltransferase (HAT)-associated transcriptional co-activators contain bromodomains, which are approximately 110-amino-acid modules found in many chromatin-associated proteins. Despite the wide occurrence of these bromodomains, their three-dimensional structure and binding partners remain unknown. Here we report the solution structure ... More