Trichloroacetic anhydride, 95%
Trichloroacetic anhydride, 95%
Trichloroacetic anhydride, 95%
Thermo Scientific Chemicals

Trichloroacetic anhydride, 95%

CAS: 4124-31-6 | C4Cl6O3 | 308.741 g/mol
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250 g
Catalog number L00849.30
also known as L00849-30
Price (USD)
320.65
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Ends: 30-Jun-2026
377.00
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Quantity:
250 g
Request bulk or custom format
Price (USD)
320.65
Special offer
Online exclusive
Ends: 30-Jun-2026
377.00
Save 56.35 (15%)
Each
Chemical Identifiers
CAS4124-31-6
IUPAC Name2,2,2-trichloroacetyl 2,2,2-trichloroacetate
Molecular FormulaC4Cl6O3
InChI KeyMEFKFJOEVLUFAY-UHFFFAOYSA-N
SMILESClC(Cl)(Cl)C(=O)OC(=O)C(Cl)(Cl)Cl
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SpecificationsSpecification SheetSpecification Sheet
Refractive Index1.4810-1.4870 @ 20?C
Appearance (Color)Clear colorless
FormLiquid
Assay (GC)≥94.0%
Identification (FTIR)Conforms
Trichloroacetic anhydride is used as a derivatization reagent involved in the analysis of amphetamine,methamphetamine and 3,4-methylenedioxymethamphetamine. It is also used in the determination of the metabolites of l-alpha-acetylmethadol (LAAM), such as noracetylmethadol, dinoracetylmethadol, methadol and normethadol by electron capture gas-liquid chromatography. It is used in the synthesis of trichloroacetonylpyridine by reacting with 2-methyl-pyridine.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Trichloroacetic anhydride is used as a derivatization reagent involved in the analysis of amphetamine,methamphetamine and 3,4-methylenedioxymethamphetamine. It is also used in the determination of the metabolites of l-alpha-acetylmethadol (LAAM), such as noracetylmethadol, dinoracetylmethadol, methadol and normethadol by electron capture gas-liquid chromatography. It is used in the synthesis of trichloroacetonylpyridine by reacting with 2-methyl-pyridine.

Solubility
Miscible with ether and acetic acid.

Notes
Moisture sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong bases with strong oxidizing agents.
RUO – Research Use Only

General References:

  1. Girard-Lauriault, P. L.; Unger, W. E.; Dietrich, P. M.; Holländer, A. Innovative and Established Strategies for the Surface Analysis of Nitrogen and Oxygen-Rich Plasma Polymer Films by XPS: An Introductory Guide. Plasma Processes Polym. 2015, 12 (9), 953-967.
  2. Frenna, V.; Palumbo Piccionello, A.; Cosimelli, B.; Ghelfi, F.; Spinelli, D. The Boulton-Katritzky Reaction: A Kinetic Study of the Effect of 5-Nitrogen Substituents on the Rearrangement of Some (Z)-Phenylhydrazones of 3-Benzoyl-1, 2, 4-oxadiazoles. Eur. J. Org. Chem. 2014, 2014 (31), 7006-7014.