(±)-trans-1,2-Diaminocyclohexane is employed in the synthesis of macrocyclic [3+3] hexa Schiff base. It also plays an important role in the preparation of multidentate ligands, chiral auxiliaries and chiral stationary phases. Further, it is used to prepare [2+2] macrocyclization by reacting with aliphatic dialdehydes. In addition to this, it acts as a chiral ligand, which finds application in asymmetric catalysis.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
(^+)-trans-1,2-Diaminocyclohexane is employed in the synthesis of macrocyclic [3+3] hexa Schiff base. It also plays an important role in the preparation of multidentate ligands, chiral auxiliaries and chiral stationary phases. Further, it is used to prepare [2+2] macrocyclization by reacting with aliphatic dialdehydes. In addition to this, it acts as a chiral ligand, which finds application in asymmetric catalysis.
Solubility
Miscible with water.
Notes
Incompatible with strong oxidizing agents and strong acids.
RUO – Research Use Only
General References:
- Francesconi, O.; Gentili, M.; Bartoli, F.; Bencini, A.; Conti, L.; Giorgi, C.; Roelens, S. Phosphate binding by a novel Zn(II) complex featuring a trans-1,2-diaminocyclohexane ligand. Effective anion recognition in water. Org. Biomol. Chem. 2015, 13, 1860-1868.
- Someshwar, N.; Ramanathan, C. R. Resolution of (±)-2,2'-dihydroxy-1,1'-binaphthyl-3,3'-dicarboxylic acid using (1R,2R)-trans-cyclohexane-1,2-diamine. Tetrahedron: Asymmetry 2015, 26 (20), 1209-1213.