3-(Trimethylsilyl)propargyl alcohol is used as a reagent to synthesize Isbogrel, a Thromboxane A 2 (TXA 2) synthase inhibitor and also a TXA 2 receptor antagonist that has potential to treat asthma.
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Applications
3-(Trimethylsilyl)propargyl alcohol is used as a reagent to synthesize Isbogrel, a Thromboxane A 2 (TXA 2) synthase inhibitor and also a TXA 2 receptor antagonist that has potential to treat asthma.
Solubility
Not miscible with water.
Notes
Moisture Sensitive. Store away from moisture and oxidizing agents. Protect from heat. Store under dry inert gas. Protect from humidity and water. Incompatible with oxidizing agents, heat and moisture.
RUO – Research Use Only
Reduction with Sodium bis(2-methoxyethoxy)aluminum hydride, A13292, gives stereoselectively (E)-3-TMS-2-propen-1-ol: Org. Synth. Coll., 7, 524 (1990). For titanocene dichloride-promoted hydromagnesiation reaction with isobutylmagnesium bromide, see: Org. Synth. Coll., 8, 507, (1993). See Bis(cyclopentadienyl)titanium dichloride, A11456.