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2-Chloro-2,2-difluoroacetophenone, 96%
2-Chloro-2,2-difluoroacetophenone, 96%
2-Chloro-2,2-difluoroacetophenone, 96%
Thermo Scientific Chemicals

2-Chloro-2,2-difluoroacetophenone, 96%

CAS: 384-67-8 | C8H5ClF2O | 190.574 g/mol
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5 g
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Catalog number L16963.03
also known as L16963-03
Price (USD)
99.65
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110.00
Save 10.35 (9%)
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Quantity:
1 g
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Price (USD)
99.65
Online Exclusive
110.00
Save 10.35 (9%)
Each
Chemical Identifiers
CAS384-67-8
IUPAC Name2-chloro-2,2-difluoro-1-phenylethan-1-one
Molecular FormulaC8H5ClF2O
InChI KeyMNOONJNILVDLSW-UHFFFAOYSA-N
SMILESFC(F)(Cl)C(=O)C1=CC=CC=C1
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SpecificationsSpecification SheetSpecification Sheet
Refractive Index1.4925-1.4985 @ 20?C
Appearance (Color)Clear colorless to yellow to orange
FormLiquid
Assay (GC)≥95.0%
Reagent is an effective product for the synthesis of difluoromethylated phenols in the presence of mild base and aqueous solvent.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Reagent is an effective product for the synthesis of difluoromethylated phenols in the presence of mild base and aqueous solvent.

Solubility
Difficult to mix.

Notes
Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.
RUO – Research Use Only

General References:

  1. Laijun Zhang.; Ji Zheng.; Jinbo Hu. 2-Chloro-2,2-difluoroacetophenone: A Non-ODS-Based Difluorocarbene Precursor and Its Use in the Difluoromethylation of Phenol Derivatives. J. Org. Chem. 2006, 71, (26), 9845-9848.
  2. Wei Zhang.; Fei Wang.; Jinbo Hu. N-Tosyl-S-difluoromethyl-S-phenylsulfoximine: A New Difluoromethylation Reagent for S-, N-, and C-Nucleophiles. Org. Lett. 2009, 11, (10), 2109-2112.