The atypical chemokine receptor D6 suppresses the development of chemically induced skin tumors.
AuthorsNibbs RJ, Gilchrist DS, King V, Ferra A, Forrow S, Hunter KD, Graham GJ,
JournalJ Clin Invest
PubMed ID17607362
'A subset of CC chemokines, acting through CC chemokine receptors (CCRs) 1 to 5, is instrumental in shaping inflammatory responses. Recently, we and others have demonstrated that the atypical chemokine receptor D6 actively sequesters and destroys many of these proinflammatory CC chemokines. This is critical for effective resolution of inflammation ... More
Expression of Th-1 chemokines and chemokine receptors on the ocular surface of C57BL/6 mice: effects of desiccating stress.
AuthorsYoon KC, De Paiva CS, Qi H, Chen Z, Farley WJ, Li DQ, Pflugfelder SC
JournalInvest Ophthalmol Vis Sci
PubMed ID17525185
To evaluate the effects of desiccating ocular surface stress on the expression of chemokines and their receptors by the corneal epithelium and conjunctiva of C57BL/6 and BALB/c mice. ... More
Abatacept limits breach of self-tolerance in a murine model of arthritis via effects on the generation of T follicular helper cells.
Abatacept modulates CD28-mediated T cell costimulation and is efficacious in the treatment of rheumatoid arthritis (RA). Its mechanism of action has not been fully elucidated but will likely reveal critical pathologic pathways in RA. We show that abatacept substantially modulated Ag-specific T and B cell responses in vivo. Ag-specific T ... More
IFN-gamma-induced chemokines synergize with pertussis toxin to promote T cell entry to the central nervous system.
AuthorsMillward JM, Caruso M, Campbell IL, Gauldie J, Owens T
JournalJ Immunol
PubMed ID17548656
Inflammation of the CNS, which occurs during multiple sclerosis and experimental autoimmune encephalomyelitis, is characterized by increased levels of IFN-gamma, a cytokine not normally expressed in the CNS. To investigate the role of IFN-gamma in CNS, we used intrathecal injection of a replication-defective adenovirus encoding murine IFN-gamma (AdIFNgamma) to IFN-gamma-deficient ... More
Oleanolic Acid, a plant triterpenoid, significantly improves survival and function of islet allograft.
AuthorsNataraju A, Saini D, Ramachandran S, Benshoff N, Liu W, Chapman W, Mohanakumar T
JournalTransplantation
PubMed ID19855244
BACKGROUND.: Oleanolic acid (OA) is a ubiquitous triterpenoid, with potent antioxidant and anti-inflammatory properties. Here, we tested whether these combined properties of OA can prevent nonimmunologic primary nonfunctioning and immunologic phenomena ascribed to graft rejection hence prolong islet allograft survival. METHODS.: Islet transplants were performed under kidney capsule of streptozotocin-induced ... More