CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus.
AuthorsWu L, Scollay R, Egerton M, Pearse M, Spangrude GJ, Shortman K
JournalNature
PubMed ID1702186
'A continuous but low input of stem cells or ''prothymocytes'' is necessary to maintain T-cell development in the adult thymus, but the colonizing cell has not been characterized. Precursors of T cells have been found in the minor CD4-8- population of thymocytes, but even the earliest cells of this population ... More
The biologic roles of CD2, CD4, and CD8 in T-cell activation.
AuthorsBierer BE, Sleckman BP, Ratnofsky SE, Burakoff SJ
JournalAnnu Rev Immunol
PubMed ID2653377
L3T4 antigen expression by hemopoietic precursor cells.
AuthorsFrederickson GG, Basch RS
JournalJ Exp Med
PubMed ID2784487
L3T4 (CD4) is expressed on immature hematopoietic cells. Sorting bone marrow cells on the basis of their expression of this antigen produces populations of cells that are markedly enriched for multipotential stem cells (CFU-s) and for myeloid precursors (CFU-c). We believe that L3T4 is transiently expressed by most, if not ... More