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Invitrogen
NALP10 Polyclonal Antibody
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Product Details
PA5-83488
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human NLRP10. Recombinant protein control fragment (Product #RP-97521).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RARYFSSYFT DEKQADRAFD IVQKNDILYK ACQVPGICWV VCSWLQGQME RGKVVLETPR NSTDIFMAYV STFLPPDDDG GCSELSRHRV
Highest antigen sequence indentity to the following orthologs: Rat - 67%, Mouse - 67%.
Target Information
NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP10 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It was initially identified as PYNOD, an Apaf-1-like protein that binds to ASC, caspase-1 and IL-1-b, inhibiting the autoprocessing of caspase-1, caspase-1-mediated IL-1-b processing, and ASC aggregation. NALP10 is thus a potent regulator of apoptosis and inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Apaf-1-like protein; pyrin-like domain- and nucleotide-binding and oligomerization domain-containing protein; NACHT, leucine rich repeat and PYD containing 10; NACHT, LRR and PYD domains-containing protein 10; Nucleotide-binding oligomerization domain protein 8; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10
Gene Aliases: CLR11.1; NALP10; NLRP10; NOD8; PAN5; PYNOD
UniProt ID: (Human) Q86W26
Entrez Gene ID: (Human) 338322
activation of innate immune response
adaptive immune response
immune system process
positive regulation of T-helper 1 type immune response
inflammatory response
positive regulation of defense response
positive regulation of interleukin-1 alpha production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
innate immune response
regulation of inflammatory response
positive regulation of inflammatory response
positive regulation of immune response
defense response to fungus
positive regulation of defense response to bacterium
positive regulation of T-helper 17 type immune response
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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