Gibco™

BMPR1A Recombinant Human Protein

Catalog number:  PHC9245

Related applications:

Mammalian Cell Culture

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Description

Bone Morphogenetic Protein Receptor 1A (BMPR1A) Fc Chimera is a bioactive protein intended for use in cell culture applications. BMPR1A is one of the bone morphogenetic protein (BMP) receptors which are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.

High purity—no interference from other proteins or contaminants
High biological activity—more results with less protein
Proven compatibility—Gibco® proteins bioassayed with Gibco® media

High Purity Recombinant Bioactive Protein
Bone Morphogenetic Protein Receptor 1A Fc Chimera is one of our more than 250 available Gibco® recombinant proteins. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.

High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Bone Morphogenetic Protein Receptor 1A (BMPR1A) specific activity is determined by its ability to inhibit human BMP4induction of alkaline phosphatase in the mouse chondrogenic cell line ATDC5.

Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.

See our selection of recombinant Gibco® growth factors.

For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number: NM_004329
Endotoxin Level: < 0.1 ng/µg
Form: Lyophilized
Indicator Cell: mouse chondrogenic cell line ATDC5
Mass: 25 µg
Product Line: Gibco®
Protein Form: Recombinant, Ligand, Fc Chimera
Purity or Quality Grade: Carrier-Free
Reactivity: Human
Research Category: Stem Cell Research, Neurobiology
Shipping Condition: Wet Ice
Species: Human
Specific Activity: ED50 range = 0.1 to 0.3 µg/ml
Gene ID (Entrez): BMPR1a
Molecular Weight: 43.7 kDa
Purification Method: Sequential Chromatography
Purity: 95 %
Protein Subtype: BMPs (Bone Morphogenetic Proteins) & Related Factors
Gene Alias: BMPR1A
Validated Application: Cell Culture
Protein Family: Growth Factors & Receptors
Expression System: Mammalian
Biological Activity: ED50 range = 0.1 to 0.3 µg/ml
Protein Tag: Untagged

Contents & storage

Store lyophilized human BMPR1a at 2 to 8°C, preferably desiccated. Upon reconstitution, apportion into working aliquots and store at ≤ –20°C. Avoid repeated freeze⁄thaw cycles.