Initiation of hepatitis delta virus genome replication
AuthorsDingle K, Bichko V, Zuccola H, Hogle J, Taylor J
JournalJ Virol
PubMed ID9573243
The small, 195-amino-acid form of the hepatitis delta virus (HDV) antigen (deltaAg-S) is essential for genome replication, i.e., for the transcription, processing, and accumulation of HDV RNAs. To better understand this requirement, we used purified recombinant deltaAg-S and HDV RNA synthesized in vitro to assemble high-molecular-weight ribonucleoprotein (RNP) structures. After ... More