S100 belongs to the family of calcium binding proteins such as calmodulin and troponin C. S100A is composed of an α and β chain whereas S100B is composed of two β chains. Antibody to S100 stains Schwannomas, ependymomas, astrogliomas, almost all benign and malignant melanomas and their metastases. S100 protein is also expressed in the antigen presenting cells such as the Langerhans cells in skin and interdigitating reticulum cells in the paracortex of lymph nodes.
Host Species: Rabbit
Species Reactivity: Human. Others not tested.
Epitope: Not determined
Immunogen: Recombinant protein encoding human S100 protein
Molecular Weight: 21-24kDa
Positive Control: Melanoma or Schwannoma
Cellular Localization: Cytoplasmic
- Immunohistochemistry (Formalin/paraffin)