Thermo Scientific™

Lab Vision™ Epidermal Growth Factor Receptor (EGFR), Rabbit Monoclonal Antibody

Related applications:

Anatomical Pathology

Ensure accurate, reproducible results in immunohistochemistry experiments with Thermo Scientific™ EGFR, Rabbit Monoclonal Antibody, part of a comprehensive antibody portfolio. Studies show rabbit monoclonal antibodies are more sensitive and specific than other available markers.

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EGFR is a type I receptor tyrosine kinase with sequence homology to c-erbB1, B2, B3, B4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-alpha (TGF-alpha), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, colon, lung, stomach, head and neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.

Host Species: Rabbit

Clone: EP38Y

Species Reactivity: Human. Others not tested.

Ig Isotype: Rabbit IgG

Epitope: Not determined

Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Tyr1068 of human EGFR

Molecular Weight: 175 kDa

Positive Control: Squamous carcinoma

Cellular Localization: Cell membrane and occasional cytoplasmic

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)