Thermo Scientific™

Lab Vision™ Pax-5, Rabbit Monoclonal Antibody

Related applications:

Anatomical Pathology

Take advantage of part of a comprehensive antibody portfolio with the Thermo Scientific™ Pax-5, Rabbit Monoclonal Antibody. Studies show rabbit monoclonal antibodies are more sensitive and specific than other available markers.
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PAX-5 is a B-cell-specific activator protein (BSAP). In the early stages of B cell developmemt, PAX-5 influences the expression of several B-cell-specific genes, such as CD19 and CD20. PAX-5 is expressed primarily in pro-, pre-, and mature B cells, but not in plasma cells. PAX-5 is expressed in most B-cell malignancies (pre-B and mature B cell lymphomas/leukemias). Over 90% of cases are positive for PAX-5 in Hodgkin's lymphoma, lymphoplasmacytic lymphoma, Merkel cell and small cell carcinoma. T-cell lymphomas, myeloma/plasmacytoma and carcinoid tumors are negative for PAX-5.

Host Species: Rabbit

Clone: SP34

Isotype: IgG

Species Reactivity: Human. Others not tested.

Immunogen: Synthetic peptide derived from the C-terminus of human PAX-5 protein

Molecular Weight: 50kDa

Positive Control: Tonsil

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)

General References:

1. Torlakovic E et at. (2002) AJSP 26:1343-50

2. Dong HY et al. (2005) AJSP. 29: 687-92

3. Jensen KC et al. (2007) Mod Pathol. 20: 871-77