Vybrant™ Multidrug Resistance Assay Kit

Catalog number:  V13180

Invitrogen™  Related applications: Cell Viability, Proliferation & Function | Cellular Imaging

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The Vybrant® Multidrug Resistance Assay Kit provides a rapid and simple method for large-scale screening of MDR inhibitors. This assay uses the fluorogenic dye calcein, AM as a substrate for efflux activity of Pgp. Calcein AM is nonfluorescent, highly lipid-soluble dye that can rapidly penetrate the plasma membrane of normal cells. Once inside the cell, ester bonds are cleaved by endogenous esterase, transforming calcein AM into the hydrophilic and intensely fluorescent dye, calcein. Multidrug resistant (MDR) cells expressing high levels of P-glycoprotein (Pgp) rapidly extrude nonfluorescent calcein AM from the plasma membrane, reducing the accumulation of fluorescent calcein relative to normal cells.
For Research Use Only. Not for use in diagnostic procedures.


Detection Method: Fluorescent
For Use With (Equipment): Microplate Reader
Format: 96-well plate
Product Line: Vybrant®
Product Size: 1 kit
Shipping Condition: Room Temperature

Contents & storage

Store in freezer (-5 to -30°C) and protect from light.


Manuals & protocols

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