Valinomycin is a natural, lipid-soluble molecule (Mr = ∼1,110) that binds potassium ions (K+) and facilitates their transfer across lipid bilayers (i.e., it is an ionophore). It is a macrocyclic molecule formed from 12 alternating amino acids and esters, synthesized by specific Streptomyces
. Valinomycin exhibits a 10,000-fold selectivity for K+ over Na+. Valinomycin is a potent antibiotic. It is commonly used as an agent to induce apoptosis and can also be used to calibrate potentiometric responses in membrane experiments involving potential-sensitive dyes such as di-4-ANEPPS
.Learn more about ion indicators including calcium, potassium, pH, and membrane potential indicators ›
• K+ selective ionophore
• Neutrally charged
• Soluble in ethanol, DMSO, etc., but insoluble in water
For Research Use Only. Not for human or animal therapeutic or diagnostic use.
For Research Use Only. Not for use in diagnostic procedures.