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In Western blot, bands are observed at ~100 kDa and ~200 kDa representing the monomer and dimer forms of WFS1.
Suggested positive control: antigen standard for WFS1 (transient overexpression lysate).
WFS1 is a novel component of Wolfram syndrome, a rare form of juvenile diabetes. WFS1 plays an important role in maintaining homeostasis of the endoplasmic reticulum (ER) in the pancreas. It is normally up-regulated during insulin secretion, whereas inactivation of the protein can cause ER stress. Chronic ER stress is a major involvement in Wolfram syndrome.
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