Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: ESVLEVHGK FVQLINTVLN GDQHFMSALD KALTSVVNYR EPKSVCKAPE LLAKYCDNLL KKSAKGMTEN EVEDRLTSFI TVFKYIDDKD VFQKFYARML AKRLIHGLSM SMDSEEAMIN KLKQACGYEF TSKLHRMYTD MSVSADLNNK FNNFIKNQDT VIDLGISFQI YVLQAGAWPL TQAPSSTFAI PQELEKSVQM FELFYSQHFS GRKLTWLHYL CTGEVKMNYL GKPYVAMVTT YQMAVLLAFN NSETVSYKEL QDSTQMNEKE LTKTIKSLLD VKMINHDSEK EDIDAESSFS LNMNFSSKRT KFKITTSMQK DTPQEMEQTR SAVDEDRKMY LQAAIVRIMK ARKVLRHNAL IQEVISQSRA RFNPSISMIK KCIEVLIDKQ YIERSQASAD EYSYVA (341-745 aa encoded by BC009591)
Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). [UniProt]
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