Product References
Toll-like receptors (TLR2 and TLR4) antagonist mitigates the onset of cerebral small vessel disease through PI3K/Akt/GSK3β pathway in stroke-prone renovascular hypertensive rats.
Biotechnology & genetic engineering reviews
Wang N,Guo W,Liu T,Chen X,Lin M
Mon Mar 06 00:00:00 EST 2023
6-Methoxydihydrosanguinarine induces apoptosis and autophagy in breast cancer MCF-7 cells by accumulating ROS to suppress the PI3K/AKT/mTOR signaling pathway.
Phytotherapy research : PTR
Zhang L,Zhang X,Che D,Zeng L,Zhang Y,Nan K,Zhang X,Zhang H,Guo Z
Sun Jan 01 00:00:00 EST 2023
MicroRNA profiling reveals the role of miR-133b-3p in promoting apoptosis and inhibiting cell proliferation and testosterone synthesis in mouse TM3 cells.
In vitro cellular & developmental biology. Animal
Pan C,Fei Q,Jin J,Zheng J,Wu D,Li H,Huang X,Kong X
Sun Jan 01 00:00:00 EST 2023
A whole transcriptome profiling analysis for antidepressant mechanism of Xiaoyaosan mediated synapse loss via BDNF/trkB/PI3K signal axis in CUMS rats.
BMC complementary medicine and therapies
Meng P,Zhang X,Liu TT,Liu J,Luo Y,Xie MX,Yang H,Fang R,Guo DW,Zhong ZY,Wang YH,Ge JW
Thu Jun 15 00:00:00 EDT 2023
TAGLN2 Promotes the Proliferation, Migration, Invasion, and EMT of Clear Cell Renal Cell Carcinoma Through the PI3K/Akt Signaling Pathway.
Biochemical genetics
He Y,Zhang B,Han D,Du Y,Zhang X,Wang H,Yue Z,Shang P
Tue Aug 01 00:00:00 EDT 2023
Baicalin and baicalein attenuate hyperuricemic nephropathy via inhibiting PI3K/AKT/NF-κB signalling pathway.
Nephrology (Carlton, Vic.)
Liu Z,Xiang H,Deng Q,Fu W,Li Y,Yu Z,Qiu Y,Mei Z,Xu L
Thu Jun 01 00:00:00 EDT 2023
HnRNP A2/B1 as a potential anti-tumor target for triptolide based on a simplified thermal proteome profiling method using XGBoost.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Chen P,Zhao P,Hu M,Wang L,Lei T,Liu B,Li L,Shi J,Lu C
Tue Aug 01 00:00:00 EDT 2023
Expression of glucose transporter-1 in follicular lymphoma affected tumor-infiltrating immunocytes and was related to progression of disease within 24 months.
Translational oncology
Deng Y,Ma J,Zhao S,Yang M,Sun Y,Zhang Q
Wed Feb 01 00:00:00 EST 2023
Taxifolin attenuates neuroinflammation and microglial pyroptosis via the PI3K/Akt signaling pathway after spinal cord injury.
International immunopharmacology
Hu Z,Xuan L,Wu T,Jiang N,Liu X,Chang J,Wang T,Han N,Tian X
Sun Jan 01 00:00:00 EST 2023
S100A6 promotes the development of thyroid cancer and inhibits apoptosis of thyroid cancer cells through the PI3K/AKT/mTOR pathway.
Pathology, research and practice
Chen B,Zheng D,Liu C,Bhandari A,Hirachan S,Shen C,Mainali S,Li H,Jiang W,Xu J,Zhang X,Tang K,Zhang W
Wed Feb 01 00:00:00 EST 2023
Demethylase FTO enhances the PI3K/Akt signaling to promote gastric cancer malignancy.
Medical oncology (Northwood, London, England)
Zhu Y,Yang J,Li Y,Xu J,Fang Z
Mon Mar 27 00:00:00 EDT 2023
TREM2 as an independent predictor of poor prognosis promotes the migration via the PI3K/AKT axis in prostate cancer.
American journal of translational research
Gao HT,Yang Z,Sun H,Zhang Y,Wang Z,Liu WY,Wen HZ,Qu CB,Wang XL
Wed Mar 15 00:00:00 EDT 2023
Acteoside Derived from Cistanche Improves Glucocorticoid-Induced Osteoporosis by Activating PI3K/AKT/mTOR Pathway.
Journal of investigative surgery : the official journal of the Academy of Surgical Research
Li S,Cui Y,Li M,Zhang W,Sun X,Xin Z,Li J
Fri Dec 01 00:00:00 EST 2023
GDNF promotes the proliferation and osteogenic differentiation of jaw bone marrow mesenchymal stem cells via the Nr4a1/PI3K/Akt pathway.
Cellular signalling
Wang Y,Gao Y,Wang Y,Zhang H,Qin Q,Xu Z,Liu S,Wang X,Qu Y,Liu Y,Jiang X,He H
Tue Aug 01 00:00:00 EDT 2023
Cancer-associated fibroblast-secreted IGFBP7 promotes gastric cancer by enhancing tumor associated macrophage infiltration via FGF2/FGFR1/PI3K/AKT axis.
Cell death discovery
Li D,Xia L,Huang P,Wang Z,Guo Q,Huang C,Leng W,Qin S
Sat Jan 21 00:00:00 EST 2023
CMTM6 overexpression confers trastuzumab resistance in HER2-positive breast cancer.
Molecular cancer
Xing F,Gao H,Chen G,Sun L,Sun J,Qiao X,Xue J,Liu C
Tue Jan 10 00:00:00 EST 2023
Integrated network pharmacology and experimental verification to explore the molecular mechanism of Jingxin Zhidong formula for treating Tic disorder.
Journal of ethnopharmacology
Tian X,Ou G,Hu S,Wang C,Han F,Gao L
Thu Apr 06 00:00:00 EDT 2023
LncRNA NR2F1-AS1 was involved in azacitidine resistance of THP-1 cells by targeting IGF1 with miR-483-3p.
Cytokine
Hu C,Li S,Fu X,Zhao X,Peng J
Wed Feb 01 00:00:00 EST 2023
Serine protease PRSS56, a novel cancer-testis antigen activated by DNA hypomethylation, promotes colorectal and gastric cancer progression via PI3K/AKT axis.
Cell & bioscience
Li D,Xia L,Huang P,Wang Z,Guo Q,Huang C,Leng W,Qin S
Mon Jul 03 00:00:00 EDT 2023
Acinous cell AR42J-derived exosome miR125b-5p promotes acute pancreatitis exacerbation by inhibiting M2 macrophage polarization via PI3K/AKT signaling pathway.
World journal of gastrointestinal surgery
Zheng Z,Cao F,Ding YX,Lu JD,Fu YQ,Liu L,Guo YL,Liu S,Sun HC,Cui YQ,Li F
Thu Apr 27 00:00:00 EDT 2023
Dietary neoagarotetraose extends lifespan and impedes brain aging in mice via regulation of microbiota-gut-brain axis.
Journal of advanced research
Li T,Yang S,Liu X,Li Y,Gu Z,Jiang Z
Sun Oct 01 00:00:00 EDT 2023
Ginsenoside Rg3 enhances the radiosensitivity of lung cancer A549 and H1299 cells via the PI3K/AKT signaling pathway.
In vitro cellular & developmental biology. Animal
Li J,Yang B
Sun Jan 01 00:00:00 EST 2023
FAM83A promotes the progression and metastasis of human pancreatic neuroendocrine tumors by inducing the epithelial-mesenchymal transition via the PI3K/AKT and ERK pathways.
Journal of endocrinological investigation
Zhou B,Zhou X,Zhan C,Jin M,Yan S
Thu Jun 01 00:00:00 EDT 2023
GSTP1-mediated S-glutathionylation of Pik3r1 is a redox hub that inhibits osteoclastogenesis through regulating autophagic flux.
Redox biology
Ji X,Hong J,Yang W,Yao M,Wang J,Jiang G,Wang Y,Li C,Lin J,Mou H,Li C,Li S,Chen Y,Shi M,Wang W,Lu F,Wu H,Zhao X,Qi Y,Yan S
Mon May 01 00:00:00 EDT 2023
Saponin extract from Achyranthes bidentata Blume alleviates disuse-induced muscle atrophy through PI3K/Akt signaling pathway.
Journal of ethnopharmacology
Shi Y,Zhang ZW,Du MM,Wu J,Li JX
Thu Aug 10 00:00:00 EDT 2023
HYOU1 promotes cell proliferation, migration, and invasion via the PI3K/AKT/FOXO1 feedback loop in bladder cancer.
Molecular biology reports
Wang W,Jiang X,Xia F,Chen X,Li G,Liu L,Xu Q,Zhu M,Chen C
Sun Jan 01 00:00:00 EST 2023
Deciphering the pharmacological mechanisms of Rostellularia procumbens (L) Nees. Extract alleviates adriamycin-induced nephropathy in vivo and in vitro.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Ai Z,Wang M,Zhou Y,Yuan D,Jian Q,Wu S,Liu B,Yang Y
Mon May 01 00:00:00 EDT 2023
Synergistic effects of L-theanine and epigallocatechin gallate in alleviating ovalbumin allergy by regulating intestinal immunity through inhibition of mast cell degranulation.
Food & function
Xu W,Song X,Qu Q,Gong Z,Xiao W
Tue Feb 21 00:00:00 EST 2023
Combination with vorinostat enhances the antitumor activity of cisplatin in castration-resistant prostate cancer by inhibiting DNA damage repair pathway and detoxification of GSH.
The Prostate
Chang T,Lian Z,Ma S,Liang Z,Ma X,Wen X,Wang Y,Liu R
Sat Apr 01 00:00:00 EDT 2023
Cytotoxic Steroidal Saponins Containing a Rare Fructosyl from the Rhizomes of Paris polyphylla var. latifolia.
International journal of molecular sciences
Li TY,Du Y,Wang MC,Liu K,Liu Y,Cao Y,Wang YY,Chen WW,Qian XY,Qiu PC,Tang HF,Lu YY
Wed Apr 12 00:00:00 EDT 2023
α2,6-Sialylation promotes hepatocellular carcinoma cells migration and invasion via enhancement of nSmase2-mediated exosomal miRNA sorting.
Journal of physiology and biochemistry
Wang L,Chen X,Meng F,Huang T,Wang S,Zheng Z,Zheng G,Li W,Zhang J,Liu Y
Wed Feb 01 00:00:00 EST 2023
Abamectin causes toxicity to the carp respiratory system by triggering oxidative stress, inflammation, and apoptosis and inhibiting autophagy.
Environmental science and pollution research international
Feng H,Zhou P,Liu F,Zhang W,Yang H,Li X,Dong J
Sat Apr 01 00:00:00 EDT 2023
Marein reduces lipid levels via modulating the PI3K/AKT/mTOR pathway to induce lipophagy.
Journal of ethnopharmacology
Zhang PP,Zhuo BY,Duan ZW,Li X,Huang SL,Cao Q,Zhao T,Wei SL,Hu XH,Zhang Y
Thu Aug 10 00:00:00 EDT 2023
Effects of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism based on miR-7/m-TOR/SREBP1 pathway on prostate cancer.
BioFactors (Oxford, England)
Xu W,Ding J,Li B,Sun T,You X,He Q,Sheng W
Wed Mar 01 00:00:00 EST 2023
Budding uninhibited by benzimidazoles 1 overexpression is associated with poor prognosis and malignant phenotype: A promising therapeutic target for lung adenocarcinoma.
Thoracic cancer
Chen R,Wang Z,Lu T,Liu Y,Ji Y,Yu Y,Tou F,Guo S
Sat Apr 01 00:00:00 EDT 2023
Gut microbiota contribute to Methamphetamine-induced cardiotoxicity in mouse model.
Chemico-biological interactions
Liu Y,Chen LJ,Li XW,Yang JZ,Liu JL,Zhang KK,Li JH,Wang Q,Xu JT,Zhi X
Sat Jul 01 00:00:00 EDT 2023
Progranulin promotes proliferation, migration and invasion via the PI3K/Akt signalling pathway in a model of endometriosis.
Reproductive biomedicine online
Qin R,Zheng F,Qin W,Wang J,Ma N,Tian W,Li J,Liao M,Qin A
Wed Mar 01 00:00:00 EST 2023
Mechanism of Xiezhuo Huayu Yiqi Tongluo Formula in the Treatment of Uric Acid Nephropathy Based on Network Pharmacology, Molecular Docking, and In Vivo Experiments.
Evidence-based complementary and alternative medicine : eCAM
Fan L,Guo Y,Wu Q,Hu T,Chen X,Guo J,Liu Y,Lu Y,Lin M
Sat Mar 04 00:00:00 EST 2023
hsa-mir-133a-2 promotes the proliferation and invasion of cervical cancer cells by targeting the LAMB3-mediated PI3K/ATK pathway.
Cancer medicine
Sui X,Sun Y,Zhang G,Chi N,Guan Y,Wang D,Li X
Wed Mar 01 00:00:00 EST 2023
Progesterone Enhances the Invasion of Trophoblast Cells by Activating PI3K/AKT Signaling Pathway to Prevent Preeclampsia.
Cell transplantation
Liu H,Yu L,Ding Y,Peng M,Deng Y
Wed Jan 04 00:00:00 EST 2023
Fibroblast growth factor 1 ameliorates thin endometrium in rats through activation of the autophagic pathway.
Frontiers in pharmacology
Zhu J,Li Z,Yin F,Yu X,Lu Y,Zhou T,Gong F,Xu Z
Tue May 09 00:00:00 EDT 2023
Vitamin C enhances the ex vivo proliferation of porcine muscle stem cells for cultured meat production.
Food & function
Fang J,Li M,Zhang G,Du G,Zhou J,Guan X,Chen J
Tue May 10 00:00:00 EDT 2022
Upregulation of SQLE Contributes to Poor Survival in Head and Neck Squamous Cell Carcinoma.
International journal of biological sciences
Li J,Yang T,Wang Q,Li Y,Wu H,Zhang M,Qi H,Zhang H,Li J
Tue Jul 12 00:00:00 EDT 2022
Chronic vitamin D3 supplementation alleviates cognition impairment via inhibition of oxidative stress regulated by PI3K/AKT/Nrf2 in APP/PS1 transgenic mice.
Neuroscience letters
Lin J,Niu Z,Xue Y,Gao J,Zhang M,Li M,Peng Y,Zhang S,Li W,Zhang Q,Li X
Wed Jul 13 00:00:00 EDT 2022
The molecular mechanism of baicalein repressing progression of gastric cancer mediating miR-7/FAK/AKT signaling pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Qiao D,Xing J,Duan Y,Wang S,Yao G,Zhang S,Jin J,Lin Z,Chen L,Piao Y
Wed Jun 01 00:00:00 EDT 2022
MiR-195 promotes pancreatic β-cell dedifferentiation by targeting Mfn2 and impairing Pi3k/Akt signaling in type 2 diabetes.
Obesity (Silver Spring, Md.)
Xu Y,Tang Z,Dai H,Hou J,Li F,Tang Z,Zhang D
Tue Feb 01 00:00:00 EST 2022
Glytabastan B, a coumestan isolated from Glycine tabacina, alleviated synovial inflammation, osteoclastogenesis and collagen-induced arthritis through inhibiting MAPK and PI3K/AKT pathways.
Biochemical pharmacology
Tu Y,Tan L,Lu T,Wang K,Wang H,Han B,Zhao Y,Chen H,Li Y,Chen H,Chen M,He C
Tue Mar 01 00:00:00 EST 2022
Banxia-Houpu decoction diminishes iron toxicity damage in heart induced by chronic intermittent hypoxia.
Pharmaceutical biology
Song JX,Zhao YS,Zhen YQ,Yang XY,Chen Q,An JR,Ji ES
Thu Dec 01 00:00:00 EST 2022
Analysis of the absorbed constituents and mechanism of liquidambaris fructus extract on hepatocellular carcinoma.
Frontiers in pharmacology
Wang S,Yang XX,Li TJ,Zhao L,Bao YR,Meng XS
Sat Sep 17 00:00:00 EDT 2022
FNDC5 Causes Resistance to Sorafenib by Activating the PI3K/Akt/Nrf2 Pathway in Hepatocellular Carcinoma Cells.
Frontiers in oncology
Liu H,Zhao L,Wang M,Yang K,Jin Z,Zhao C,Shi G
Sat Apr 09 00:00:00 EDT 2022
Shexiang Tongxin Dropping Pills Promote Macrophage Polarization-Induced Angiogenesis Against Coronary Microvascular Dysfunction via PI3K/Akt/mTORC1 Pathway.
Frontiers in pharmacology
Lu X,Yao J,Li C,Cui L,Liu Y,Liu X,Wang G,Dong J,Deng Q,Hu Y,Guo D,Wang W,Li C
Wed Apr 13 00:00:00 EDT 2022
Postoperative Ileus with the Topical Application of Tongfu Decoction Based on Network Pharmacology and Experimental Validation.
Evidence-based complementary and alternative medicine : eCAM
Zuo X,Shi X,Zhang X,Chen Z,Yang Z,Pan X,Lai R,Zhao Z
Fri Apr 08 00:00:00 EDT 2022
Integrated Network Pharmacology and Experimental Verification to Explore the Molecular Mechanism of Hedysarum Multijugum Maxim-Curcumae Rhizoma Herb Pair for Treating Non-Small Cell Lung Cancer.
Frontiers in oncology
Hu S,Ge M,Zhang S,Jiang M,Hu K,Gao L
Sat May 07 00:00:00 EDT 2022
The influence of perinatal maternal exposure to dibutyl phthalate on glucolipid metabolism in adult female offspring.
Obesity research & clinical practice
Zhou K,Cheng R,Zhu M,Yang M,Shen X,Luo X,Ma L,Xu L,Zhang J
Mon Dec 12 00:00:00 EST 2022
Interpreting the Pharmacological Mechanisms of Sho-saiko-to on Thyroid Carcinoma through Combining Network Pharmacology and Experimental Evaluation.
ACS omega
Wang K,Qian R,Li H,Wang C,Ding Y,Gao Z
Tue Apr 05 00:00:00 EDT 2022
Antidepressant-Like Effect and Mechanism of Ginsenoside Rd on Rodent Models of Depression.
Drug design, development and therapy
Li Y,Wang ML,Zhang B,Fan XX,Tang Q,Yu X,Li LN,Fan AR,Chang HS,Zhang LZ
Tue Apr 05 00:00:00 EDT 2022
Protection of CAPE-pNO2 Against Chronic Myocardial Ischemia by the TGF-Β1/Galectin-3 Pathway In Vivo and In Vitro.
Inflammation
Wan Q,Zhang L,Zhou Q,Han Y,Li Z,Li B
Wed Jun 01 00:00:00 EDT 2022
Effect of Thymoquinone on Renal Damage Induced by Hyperlipidemia in LDL Receptor-Deficient (LDL-R-/-) Mice.
BioMed research international
Li W,Zhang H,Zhang L,Zhang T,Ding H
Tue Jul 19 00:00:00 EDT 2022
CircSEMA4B inhibits the progression of breast cancer by encoding a novel protein SEMA4B-211aa and regulating AKT phosphorylation.
Cell death & disease
Wang X,Jian W,Luo Q,Fang L
Sat Sep 17 00:00:00 EDT 2022
CircSEMA4B inhibits the progression of breast cancer by encoding a novel protein SEMA4B-211aa and regulating AKT phosphorylation.
Cell death & disease
Wang X,Jian W,Luo Q,Fang L
Sat Sep 17 00:00:00 EDT 2022
Stanniocalcin 1 promotes metastasis, lipid metabolism and cisplatin chemoresistance via the FOXC2/ITGB6 signaling axis in ovarian cancer.
Journal of experimental & clinical cancer research : CR
Lin F,Li X,Wang X,Sun H,Wang Z,Wang X
Thu Apr 07 00:00:00 EDT 2022
HRK inhibits colorectal cancer cells proliferation by suppressing the PI3K/AKT/mTOR pathway.
Frontiers in oncology
Wang H,Chen Y,Yuan Q,Chen L,Dai P,Li X
Tue Jan 03 00:00:00 EST 2023
The Spike Protein of SARS-CoV-2 Impairs Lipid Metabolism and Increases Susceptibility to Lipotoxicity: Implication for a Role of Nrf2.
Cells
Nguyen V,Zhang Y,Gao C,Cao X,Tian Y,Carver W,Kiaris H,Cui T,Tan W
Tue Jun 14 00:00:00 EDT 2022
Glycyrrhizic Acid Attenuates Pulmonary Fibrosis of Silicosis by Inhibiting the Interaction between HMGB1 and BRG1 through PI3K/Akt/mTOR Pathway.
International journal of environmental research and public health
Niu Z,Lin J,Hao C,Xu X,Wang C,Dai K,Deng X,Deng M,Guo Y,Yao W
Mon Jul 18 00:00:00 EDT 2022
Effects of Bisphenol A on reproductive toxicity and gut microbiota dysbiosis in male rats.
Ecotoxicology and environmental safety
Liu R,Cai D,Li X,Liu B,Chen J,Jiang X,Li H,Li Z,Teerds K,Sun J,Bai W,Jin Y
Fri Jul 01 00:00:00 EDT 2022
Effects of Bisphenol A on reproductive toxicity and gut microbiota dysbiosis in male rats.
Ecotoxicology and environmental safety
Liu R,Cai D,Li X,Liu B,Chen J,Jiang X,Li H,Li Z,Teerds K,Sun J,Bai W,Jin Y
Fri Jul 01 00:00:00 EDT 2022
Selenium protects against cadmium-induced cardiac injury by attenuating programmed cell death via PI3K/AKT/PTEN signaling.
Environmental toxicology
Feng J,Yang F,Wu H,Xing C,Xue H,Zhang L,Zhang C,Hu G,Cao H
Sun May 01 00:00:00 EDT 2022
Multi-material basis and multi-mechanisms of the Dahuang Zhechong pill for regulating Treg/Th1 balance in hepatocellular carcinoma.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Wu L,Yang FR,Xing ML,Lu SF,Chen HL,Yang QW,Zhang YT,Lu Y,Huang Y
Wed Jun 01 00:00:00 EDT 2022
Peroxiredoxin 4 regulates tumor-cell-like characteristics of fibroblast-like synoviocytes in rheumatoid arthritis through PI3k/Akt signaling pathway.
Clinical immunology (Orlando, Fla.)
Aihaiti Y,Tuerhong X,Zheng H,Cai Y,Yang M,Xu P
Fri Apr 01 00:00:00 EDT 2022
Scutellarin-mediated autophagy activates exosome release of rat nucleus pulposus cells by positively regulating Rab8a via the PI3K/PTEN/Akt pathway.
Cell biology international
Hu SQ,Zou YP,Jiang YQ,Zhang QC,Cheng HX,Wang HR,Li XL
Sat Oct 01 00:00:00 EDT 2022
A Novel Mast Cell Stabilizer JM25-1 Rehabilitates Impaired Gut Barrier by Targeting the Corticotropin-Releasing Hormone Receptors.
Pharmaceuticals (Basel, Switzerland)
Sun Y,Li H,Liu L,Bai X,Wu L,Shan J,Sun X,Wang Q,Guo Y
Thu Dec 29 00:00:00 EST 2022
Exploration of the Effect and Potential Mechanism of Echinacoside Against Endometrial Cancer Based on Network Pharmacology and in vitro Experimental Verification.
Drug design, development and therapy
Shu W,Wang Z,Zhao R,Shi R,Zhang J,Zhang W,Wang H
Fri Jun 24 00:00:00 EDT 2022
Rice protein suppresses 4-hydroxy-2-nonenal-induced inflammation owing to methionine availability.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
Wang Z,Liang M,Li H,Liu B,Yang L
Mon Aug 01 00:00:00 EDT 2022
The inhibitory effect and mechanism of Yi-qi-hua-yu-jie-du decoction on the drug resistance of gastric cancer stem cells based on ABC transporters.
Chinese medicine
Huang W,Wen F,Gu P,Liu J,Xia Y,Li Y,Zhou J,Song S,Ruan S,Gu S,Chen X,Shu P
Tue Aug 09 00:00:00 EDT 2022
Chromogranin A-derived peptide CGA47-66 protects against septic brain injury by reducing blood-brain barrier damage through the PI3K/AKT pathway.
Biochemical and biophysical research communications
Wang F,Zeng Y,Liu X,Cao J,Kang S,Zhou W,Chen X,Liu J,Zhang D
Sat May 21 00:00:00 EDT 2022
HIF-1α induced NID1 expression promotes pulmonary metastases via the PI3K-AKT pathway in salivary gland adenoid cystic carcinoma.
Oral oncology
Han N,Li X,Wang Y,Li H,Zhang C,Zhao X,Zhang Z,Ruan M,Zhang C
Mon Aug 01 00:00:00 EDT 2022
Chicoric acid attenuates tumor necrosis factor-α-induced inflammation and apoptosis via the Nrf2/HO-1, PI3K/AKT and NF-κB signaling pathways in C28/I2 cells and ameliorates the progression of osteoarthritis in a rat model.
International immunopharmacology
Qu Y,Shen Y,Teng L,Huang Y,Yang Y,Jian X,Fan S,Wu P,Fu Q
Sat Oct 01 00:00:00 EDT 2022
Baicalin ameliorates APEC-induced intestinal injury in chicks by inhibiting the PI3K/AKT-mediated NF-κB signaling pathway.
Poultry science
Cheng X,Cao Z,Luo J,Hu R,Cao H,Guo X,Xing C,Yang F,Zhuang Y,Hu G
Sat Jan 01 00:00:00 EST 2022
Chronic exposure to polyvinyl chloride microplastics induces liver injury and gut microbiota dysbiosis based on the integration of liver transcriptome profiles and full-length 16S rRNA sequencing data.
The Science of the total environment
Chen X,Zhuang J,Chen Q,Xu L,Yue X,Qiao D
Thu Sep 15 00:00:00 EDT 2022
Traditional Chinese medicine CFF-1 exerts a potent anti-tumor immunity to hinder tumor growth and metastasis in prostate cancer through EGFR/JAK1/STAT3 pathway to inhibit PD-1/PD-L1 checkpoint signaling.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Zhang Y,Wei Y,Jiang S,Dang Y,Yang Y,Zuo W,Zhu Q,Liu P,Gao Y,Lu S
Sun May 01 00:00:00 EDT 2022
Dandelion Seed Extract Affects Tumor Progression and Enhances the Sensitivity of Cisplatin in Esophageal Squamous Cell Carcinoma.
Frontiers in pharmacology
Li Y,Deng Y,Zhang X,Fu H,Han X,Guo W,Zhao W,Zhao X,Yu C,Li H,Lei K,Wang T
Sat Jul 16 00:00:00 EDT 2022
Thymopentin-Mediated Inhibition of Cancer Stem Cell Stemness Enhances the Cytotoxic Effect of Oxaliplatin on Colon Cancer Cells.
Frontiers in pharmacology
Yu PC,Liu D,Han ZX,Liang F,Hao CY,Lei YT,Guo CR,Wang WH,Li XH,Yang XN,Li CZ,Yu Y,Fan YZ
Sat Mar 05 00:00:00 EST 2022
Frankincense myrrh attenuates hepatocellular carcinoma by regulating tumor blood vessel development through multiple epidermal growth factor receptor-mediated signaling pathways.
World journal of gastrointestinal oncology
Zheng P,Huang Z,Tong DC,Zhou Q,Tian S,Chen BW,Ning DM,Guo YM,Zhu WH,Long Y,Xiao W,Deng Z,Lei YC,Tian XF
Tue Feb 15 00:00:00 EST 2022
Protective Effects of Herba Houttuyniae Aqueous Extract against OVA-Induced Airway Hyperresponsiveness and Inflammation in Asthmatic Mice.
Evidence-based complementary and alternative medicine : eCAM
Yang Y,Lai Q,Wang C,Zhou G
Tue Nov 22 00:00:00 EST 2022
Knockdown of USP8 inhibits prostate cancer cell growth, proliferation, and metastasis and promotes docetaxel's activity by suppressing the NF-kB signaling pathway.
Frontiers in oncology
Islam MT,Chen FZ,Chen HC,Wahid A
Tue Nov 08 00:00:00 EST 2022
Anti-fatigue effects of fermented soybean protein peptides in mice.
Journal of the science of food and agriculture
Fang L,Zhang RX,Wei Y,Ling K,Lu L,Wang J,Pan XC,Cai MY
Sun May 01 00:00:00 EDT 2022
Identification of a five m6A-relevant mRNAs signature and risk score for the prognostication of gastric cancer.
Journal of gastrointestinal oncology
Yin L,Feng S,Sun Y,Jiang Y,Tang C,Sun D
Sat Oct 01 00:00:00 EDT 2022
Overexpression of sFlt-1 represses ox-LDL-induced injury of HUVECs by activating autophagy via PI3K/AKT/mTOR pathway.
Microvascular research
Zhou YH,Tang YZ,Guo LY,Zheng LL,Zhang D,Yang CY,Wang W
Sat Jan 01 00:00:00 EST 2022
Gomisin A enhances the antitumor effect of paclitaxel by suppressing oxidative stress in ovarian cancer.
Oncology reports
Wang T,Liu J,Huang X,Zhang C,Shangguan M,Chen J,Wu S,Chen M,Yang Z,Zhao S
Tue Nov 01 00:00:00 EDT 2022
Isovitexin protects against acute liver injury by targeting PTEN, PI3K and BiP via modification of m6A.
European journal of pharmacology
Huang Y,Chen S,Pang L,Feng Z,Su H,Zhu W,Wei J
Tue Feb 15 00:00:00 EST 2022
A ROS-Responsive Liposomal Composite Hydrogel Integrating Improved Mitochondrial Function and Pro-Angiogenesis for Efficient Treatment of Myocardial Infarction.
Advanced healthcare materials
Zheng Z,Lei C,Liu H,Jiang M,Zhou Z,Zhao Y,Yu CY,Wei H
Sat Oct 01 00:00:00 EDT 2022
Effect of thymoquinone on sepsis-induced cardiac damage via anti-inflammatory and anti-apoptotic mechanisms.
The Journal of international medical research
Guo W,Long X,Lv M,Deng S,Liu D,Yang Q
Thu Sep 01 00:00:00 EDT 2022
The crucial role of thioredoxin interacting protein in the liver insulin resistance induced by di (2-ethylhexyl) phthalates.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Zhang W,Xu P,Li JY
Wed Jun 01 00:00:00 EDT 2022
Shikonin Mediates Apoptosis through G Protein-Coupled Estrogen Receptor of Ovarian Cancer Cells.
Evidence-based complementary and alternative medicine : eCAM
Liu X,Yang Y,Tang X,Guo L,Tang X,Zhu T,Zhao T,Zhang W,Zhang P
Wed Oct 19 00:00:00 EDT 2022
Kub3 Deficiency Causes Aberrant Late Embryonic Lung Development in Mice by the FGF Signaling Pathway.
International journal of molecular sciences
Yang G,Lu S,Jiang J,Weng J,Zeng X
Fri May 27 00:00:00 EDT 2022
si-PDGFRβ-Loaded Exosomes Suppress the Progression of Glioma by Inhibiting the Oxidative Associated PI3K/Akt/EZH2 Signaling Pathway.
Oxidative medicine and cellular longevity
Li Y,Yu H,Ma Q,Wei M,Liu X,Qi Y,Li C,Dong L,Zhang H
Thu Oct 27 00:00:00 EDT 2022
Systemic pharmacological verification of Salvia miltiorrhiza-Ginseng Chinese herb pair in inhibiting spontaneous breast cancer metastasis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Han H,Qian C,Zong G,Liu H,Wang F,Tao R,Cheng P,Wei Z,Zhao Y,Lu Y
Thu Dec 01 00:00:00 EST 2022
Knockdown of forkhead box protein P1 alleviates hypoxia reoxygenation injury in H9c2 cells through regulating Pik3ip1/Akt/eNOS and ROS/mPTP pathway.
Bioengineered
Liu X,Yang Y,Song J,Li D,Liu X,Li C,Ma Z,Zhong J,Wang L
Sat Jan 01 00:00:00 EST 2022
6-Hydroxydopamine-Induced Neurotoxicity in Rat Model of Parkinson's Disease: Is Reversed via Anti-Oxidative Activities of Curcumin and Aerobic Exercise Therapy.
Physiological research
Sokouti H,Mohajeri D,Nourazar MA
Wed Aug 31 00:00:00 EDT 2022
Evodiamine as the Active Compound of Evodiae fructus to Inhibit Proliferation and Migration of Prostate Cancer through PI3K/AKT/NF-κB Signaling Pathway.
Disease markers
Lei Y,Chan M,Liu H,Lyu W,Chen L,Zhong Y,Gan H,Wang M,Qi M,Guo Y,Liu J,Zhang E
Fri Jul 29 00:00:00 EDT 2022
MMP-9 secreted by M2-type macrophages promotes Wilms' tumour metastasis through the PI3K/AKT pathway.
Molecular biology reports
Tian K,Du G,Wang X,Wu X,Li L,Liu W,Wu R
Sun May 01 00:00:00 EDT 2022
YAP1-TEAD1 mediates the perineural invasion of prostate cancer cells induced by cancer-associated fibroblasts.
Biochimica et biophysica acta. Molecular basis of disease
Shen T,Li Y,Wang D,Su Y,Li G,Shang Z,Niu Y,Tan X
Thu Dec 01 00:00:00 EST 2022
Forkhead Box q1 promotes invasion and metastasis in colorectal cancer by activating the epidermal growth factor receptor pathway.
World journal of gastroenterology
Zhang JJ,Cao CX,Wan LL,Zhang W,Liu ZJ,Wang JL,Guo Q,Tang H
Sat May 07 00:00:00 EDT 2022
Lysophosphatidylcholine acyltransferase 1 alleviates silica-induced pulmonary fibrosis by modulating lipid metabolism.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Deng X,Hao C,Li Y,Guo Y,Si H,He J,Deng M,Niu Z,Wang C,Xu X,Dai K,Yao W
Tue Nov 01 00:00:00 EDT 2022
Spindle and kinetochore-associated complex 3 promotes cell growth via the PI3K/AKT/GSK3β and PI3K/AKT/FOXO1 pathways and is a potential prognostic biomarker for oral squamous cell carcinoma.
Oral surgery, oral medicine, oral pathology and oral radiology
Xu H,Chen G,Niu Q,Song K,Feng Z,Han Z
Tue Nov 01 00:00:00 EDT 2022
Human umbilical vein endothelial cells-derived exosomes enhance cardiac function after acute myocardial infarction by activating the PI3K/AKT signaling pathway.
Bioengineered
Liu W,Feng Y,Wang X,Ding J,Li H,Guan H,Chen Z
Fri Apr 01 00:00:00 EDT 2022
The In Vitro Effect of Psoralen on Glioma Based on Network Pharmacology and Potential Target Research.
Evidence-based complementary and alternative medicine : eCAM
Wu Y,Zhang YZ,Li MJ,Yang WQ,Cheng LF
Wed Sep 07 00:00:00 EDT 2022
Circular RNA BIRC6 depletion promotes osteogenic differentiation of periodontal ligament stem cells via the miR-543/PTEN/PI3K/AKT/mTOR signaling pathway in the inflammatory microenvironment.
Stem cell research & therapy
Zhao X,Sun W,Guo B,Cui L
Sat Aug 13 00:00:00 EDT 2022
Irradiation-induced exosomal HMGB1 to confer radioresistance via the PI3K/AKT/FOXO3A signaling pathway in ESCC.
Journal of translational medicine
Du X,Zhang X,Dong J,Zou N,Guo D,Yao W,Wang X,Li S,Song C,Yan K,Shen W,Zhu S
Sat Nov 05 00:00:00 EDT 2022
Avermectin induces carp neurotoxicity by mediating blood-brain barrier dysfunction, oxidative stress, inflammation, and apoptosis through PI3K/Akt and NF-κB pathways.
Ecotoxicology and environmental safety
Zhang T,Dong Z,Liu F,Pan E,He N,Ma F,Wang G,Wang Y,Dong J
Thu Sep 15 00:00:00 EDT 2022
Shikonin induces apoptosis and autophagy via downregulation of pyrroline-5-carboxylate reductase1 in hepatocellular carcinoma cells.
Bioengineered
Zhang J,Shang L,Jiang W,Wu W
Tue Mar 01 00:00:00 EST 2022
Dynamic changes in human THP-1-derived M1-to-M2 macrophage polarization during Thelazia callipaeda MIF induction.
Frontiers in immunology
Yin C,Cai J,Gou Y,Li D,Tang H,Wang L,Liu H,Luo B
Wed Feb 01 00:00:00 EST 2023
Elucidation of the interaction effect between dietary fiber and bound polyphenol components on the anti-hyperglycemic activity of tea residue dietary fiber.
Food & function
Huang H,Chen J,Hu X,Chen Y,Xie J,Ao T,Wang H,Xie J,Yu Q
Mon Mar 07 00:00:00 EST 2022
MicroRNA-221-5p Promotes Ricin Toxin-induced Inflammation via PI3K/Akt signaling pathway by targeting COL4a5.
Toxicon : official journal of the International Society on Toxinology
Zhao N,Yu H,Xi Y,Dong M,Wang Y,Sun C,Zhang J,Xu N,Liu W
Wed Jun 01 00:00:00 EDT 2022
The protective effect of proanthocyanidins on the psoriasis-like cell models via PI3K/AKT and HO-1.
Redox report : communications in free radical research
Zhao Y,Xie Y,Li X,Song J,Guo M,Xian D,Zhong J
Thu Dec 01 00:00:00 EST 2022
RABENOSYN separation-of-function mutations uncouple endosomal recycling from lysosomal degradation, causing a distinct Mendelian disorder.
Human molecular genetics
Paul F,Ng C,Mohamad Sahari UB,Nafissi S,Nilipoor Y,Tavasoli AR,Bonnard C,Wong PM,Nabavizadeh N,Altunoğlu U,Estiar MA,Majoie CB,Lee H,Nelson SF,Gan-Or Z,Rouleau GA,Van Veldhoven PP,Massie R,Hennekam RC,Kariminejad A,Reversade B
Fri Oct 28 00:00:00 EDT 2022
ELA-11 protects the heart against oxidative stress injury induced apoptosis through ERK/MAPK and PI3K/AKT signaling pathways.
Frontiers in pharmacology
Wang X,Zhang L,Feng M,Xu Z,Cheng Z,Qian L
Wed Sep 28 00:00:00 EDT 2022
Astragaloside IV - mediated endothelial progenitor cell exosomes promote autophagy and inhibit apoptosis in hyperglycemic damaged endothelial cells via miR-21/PTEN axis.
Folia histochemica et cytobiologica
Xiong W,Huang XL,Li CY,Wang XL,Lan HW,Wang TT,Chen ZL,Yang QP,Hu AL,Xia YF,Zhu FR,Zhou ZZ
Mon Jan 02 00:00:00 EST 2023
Diallyl Trisulfide Enhances the Survival of Multiterritory Perforator Skin Flaps.
Frontiers in pharmacology
Dong C,Chen Z,Zhu L,Bsoul N,Wu H,Jiang J,Chen X,Lai Y,Yu G,Gu Y,Guo X,Gao W
Sat Mar 05 00:00:00 EST 2022
Hax-1 Regulates Radiation-Induced Mitochondrial-Dependent Apoptosis of Uveal Melanoma Cells through PI3K/AKT/eNOS Pathway.
Journal of oncology
Wang S,Tan J,Chen L,Wang J
Sat Jul 16 00:00:00 EDT 2022
IL-8 exacerbates CCl4-induced liver fibrosis in human IL-8-expressing mice via the PI3K/Akt/HIF-1α pathway.
Molecular immunology
Ma Y,Bao Y,Wu L,Ke Y,Tan L,Ren H,Song J,Zhang Q,Jin Y
Thu Dec 01 00:00:00 EST 2022
Fucoidan ameliorates glucose metabolism by the improvement of intestinal barrier and inflammatory damage in type 2 diabetic rats.
International journal of biological macromolecules
Liu Y,Xu Z,Huang H,Xue Y,Zhang D,Zhang Y,Li W,Li X
Tue Mar 15 00:00:00 EDT 2022
Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats.
Food & function
Liu Y,Huang H,Xu Z,Xue Y,Zhang D,Zhang Y,Li W,Li X
Mon Mar 07 00:00:00 EST 2022
Jatrorrhizine from Rhizoma Coptidis exerts an anti-obesity effect in db/db mice.
Journal of ethnopharmacology
He H,Deng J,Yang M,An L,Ye X,Li X
Tue Nov 15 00:00:00 EST 2022
β-Carotene Attenuates Apoptosis and Autophagy via PI3K/AKT/mTOR Signaling Pathway in Necrotizing Enterocolitis Model Cells IEC-6.
Evidence-based complementary and alternative medicine : eCAM
Xu G,Ma T,Zhou C,Zhao F,Peng K,Li B
Sat Jul 16 00:00:00 EDT 2022
Bolbostemma paniculatum (Maxim.) Franquet extract suppresses the development of colorectal cancer through downregulation of PI3K/Akt pathway.
Journal of ethnopharmacology
Li Y,Sun Y,Zhang Q,Liu Y,Niu Y,Li X,Cai D
Wed Apr 06 00:00:00 EDT 2022
Pan-cancer analysis of trophinin-associated protein with potential implications in clinical significance, prognosis, and tumor microenvironment in human cancers.
Frontiers in oncology
Li Z,Pu Z,Yang Z,Zhu Y,Deng Y,Li N,Peng F
Fri Nov 25 00:00:00 EST 2022
Stilbene B10 induces apoptosis and tumor suppression in lymphoid Raji cells by BTK-mediated regulation of the KRAS/HDAC1/EP300/PEBP1 axis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Varier KM,Dan G,Liu W,Wu G,Xiao C,Lei H,Ling T,Jiang Y,Chen Y,Ben-David Y,Li Y,Zhang N,Gajendran B,Shen X
Thu Dec 01 00:00:00 EST 2022
Downregulated MicroRNA-327 Attenuates Oxidative Stress-Mediated Myocardial Ischemia Reperfusion Injury Through Regulating the FGF10/Akt/Nrf2 Signaling Pathway.
Frontiers in pharmacology
Zheng T,Yang J,Zhang J,Yang C,Fan Z,Li Q,Zhai Y,Liu H,Yang J
Wed May 26 00:00:00 EDT 2021
Procyanidin B2 alleviates liver injury caused by cold stimulation through Sonic hedgehog signalling and autophagy.
Journal of cellular and molecular medicine
Ma L,Li C,Lian S,Xu B,Lv H,Liu Y,Lu J,Ji H,Li S,Guo J,Yang H
Sun Aug 01 00:00:00 EDT 2021
An integrated network pharmacology and transcriptomic method to explore the mechanism of the total Rhizoma Coptidis alkaloids in improving diabetic nephropathy.
Journal of ethnopharmacology
Xiao Y,Liu Y,Lai Z,Huang J,Li C,Zhang Y,Gong X,Deng J,Ye X,Li X
Sat Apr 24 00:00:00 EDT 2021
Vicenin-2 inhibits the Helicobacterium pylori infection associated gastric carcinogenic events through modulation of PI3K/AKT and Nrf2 signaling in GES-1 cells.
Journal of biochemical and molecular toxicology
Zhang Y,Sun J,Dong Y,Shen X,Zhang Z
Mon Mar 01 00:00:00 EST 2021
Epigallocatechin-3-gallate inhibits proliferation and triggers apoptosis in colon cancer via the hedgehog/phosphoinositide 3-kinase pathways.
Canadian journal of physiology and pharmacology
Ding F,Yang S
Wed Sep 01 00:00:00 EDT 2021
Alpha-Enolase Protects Hepatocyte Against Heat Stress Through Focal Adhesion Kinase-Mediated Phosphatidylinositol 3-Kinase/Akt Pathway.
Frontiers in genetics
Zeng T,Cao Y,Gu T,Chen L,Tian Y,Li G,Shen J,Tao Z,Lu L
Fri Aug 06 00:00:00 EDT 2021
PKCα mediated by the PI3K/Akt-FOXA1 cascade facilitates cypermethrin-induced hyperthyroidism.
The Science of the total environment
Ha M,Huang X,Li L,Lu D,Liu C
Thu Feb 25 00:00:00 EST 2021
LPAR5 promotes thyroid carcinoma cell proliferation and migration by activating class IA PI3K catalytic subunit p110β.
Cancer science
Zhao WJ,Zhu LL,Yang WQ,Xu SJ,Chen J,Ding XF,Liang Y,Chen G
Thu Apr 01 00:00:00 EDT 2021
Integrating bioinformatics with pharmacological evaluation for illustrating the action mechanism of herbal formula Jiao'e mixture in suppressing lung carcinoma.
Journal of ethnopharmacology
Qian Y,Shanbo M,Shaojie H,Long L,Yuhan C,Jin W,Shan M,Xiao-Peng S
Sun Dec 05 00:00:00 EST 2021
Abnormal Glu/mGluR2/3/PI3K pathway in the hippocampal neurovascular unit leads to diabetes-related depression.
Neural regeneration research
Liu J,Han YS,Liu L,Tang L,Yang H,Meng P,Zhao HQ,Wang YH
Thu Apr 01 00:00:00 EDT 2021
Cyanidin-3-glucoside suppresses the progression of lung adenocarcinoma by downregulating TP53I3 and inhibiting PI3K/AKT/mTOR pathway.
World journal of surgical oncology
Chen X,Zhang W,Xu X
Fri Aug 06 00:00:00 EDT 2021
In Silico and In Vivo Studies on the Mechanisms of Chinese Medicine Formula (Gegen Qinlian Decoction) in the Treatment of Ulcerative Colitis.
Frontiers in pharmacology
Liu X,Fan Y,Du L,Mei Z,Fu Y
Tue Jun 29 00:00:00 EDT 2021
Pinocembrin Inhibits the Proliferation and Metastasis of Breast Cancer via Suppression of the PI3K/AKT Signaling Pathway.
Frontiers in oncology
Zhu X,Li R,Wang C,Zhou S,Fan Y,Ma S,Gao D,Gai N,Yang J
Tue Aug 03 00:00:00 EDT 2021
Radiotherapy programs neutrophils to an antitumor phenotype by inducing mesenchymal-epithelial transition.
Translational lung cancer research
Liu Q,Hao Y,Du R,Hu D,Xie J,Zhang J,Deng G,Liang N,Tian T,Käsmann L,Rades D,Rim CH,Hu P,Zhang J
Mon Mar 01 00:00:00 EST 2021
Shexiang Baoxin Pills Inhibited Proliferation and Migration of Human Coronary Artery Smooth Muscle Cells via PI3K/AKT/mTOR Pathway.
Frontiers in cardiovascular medicine
Hua L,Zhou Y,Hou C,Chen J,Wang Y,Zhang S,Zhou H,He S,Jia E
Tue Sep 14 00:00:00 EDT 2021
Role of Epigallocatechin Gallate in Glucose, Lipid, and Protein Metabolism and L-Theanine in the Metabolism-Regulatory Effects of Epigallocatechin Gallate.
Nutrients
Lin L,Zeng L,Liu A,Yuan D,Peng Y,Zhang S,Li Y,Chen J,Xiao W,Gong Z
Wed Nov 17 00:00:00 EST 2021
Treatment of keloids through Runx2 siRNA‑induced inhibition of the PI3K/AKT signaling pathway.
Molecular medicine reports
Lv W,Wu M,Ren Y,Luo X,Hu W,Zhang Q,Wu Y
Fri Jan 01 00:00:00 EST 2021
Oxymatrine pretreatment protects H9c2 cardiomyocytes from hypoxia/reoxygenation injury by modulating the PI3K/Akt pathway.
Experimental and therapeutic medicine
Zhang Z,Qin X,Wang Z,Li Y,Chen F,Chen R,Li C,Zhang W,Zhang M
Tue Jun 01 00:00:00 EDT 2021
Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen.
Ecotoxicology and environmental safety
Zhao G,Qi L,Wang Y,Li X,Li Q,Tang X,Wang X,Wu C
Fri Oct 01 00:00:00 EDT 2021
Edaravone Alleviated Propofol-Induced Neurotoxicity in Developing Hippocampus by mBDNF/TrkB/PI3K Pathway.
Drug design, development and therapy
Yang Y,Yi J,Pan M,Hu B,Duan H
Tue Oct 26 00:00:00 EDT 2021
Dandelion root extract affects ESCC progression via regulating multiple signal pathways.
Food & function
Duan X,Pan L,Deng Y,Liu Y,Han X,Fu H,Li Y,Li M,Wang T
Mon Oct 04 00:00:00 EDT 2021
Oxytocin Protects Against Isoproterenol-Induced Cardiac Hypertrophy by Inhibiting PI3K/AKT Pathway via a lncRNA GAS5/miR-375-3p/KLF4-Dependent Mechanism.
Frontiers in pharmacology
Yang Y,Wang Z,Yao M,Xiong W,Wang J,Fang Y,Yang W,Jiang H,Song N,Liu L,Qian J
Tue Dec 21 00:00:00 EST 2021
Tanshinone IIA affects the malignant growth of Cholangiocarcinoma cells by inhibiting the PI3K-Akt-mTOR pathway.
Scientific reports
Liu H,Liu C,Wang M,Sun D,Zhu P,Zhang P,Tan X,Shi G
Wed Sep 29 00:00:00 EDT 2021
Postnatal overfeeding induces hepatic microRNA-221 expression and impairs the PI3K/AKT pathway in adult male rats.
Pediatric research
Huang F,Zhu P,Wang J,Chen J,Lin W
Fri Jan 01 00:00:00 EST 2021
Environmentally relevant concentration of sulfamethoxazole-induced oxidative stress-cascaded damages in the intestine of grass carp and the therapeutic application of exogenous lycopene.
Environmental pollution (Barking, Essex : 1987)
Wang Y,Zhao H,Liu Y,Li J,Nie X,Huang P,Xing M
Thu Apr 01 00:00:00 EDT 2021
Ginsenoside Rg5 Improves Insulin Resistance and Mitochondrial Biogenesis of Liver via Regulation of the Sirt1/PGC-1α Signaling Pathway in db/db Mice.
Journal of agricultural and food chemistry
Zhu Y,Yang H,Deng J,Fan D
Wed Aug 04 00:00:00 EDT 2021
A novel cystathionine γ-lyase inhibitor, I194496, inhibits the growth and metastasis of human TNBC via downregulating multiple signaling pathways.
Scientific reports
Liu Y,Wang L,Zhang X,Deng Y,Pan L,Li H,Shi X,Wang T
Mon Apr 26 00:00:00 EDT 2021
Astragaloside IV Attenuates the Myocardial Injury Caused by Adriamycin by Inhibiting Autophagy.
Frontiers in pharmacology
Luo LF,Qin LY,Wang JX,Guan P,Wang N,Ji ES
Sat Jun 12 00:00:00 EDT 2021
Astragaloside IV Attenuates the Myocardial Injury Caused by Adriamycin by Inhibiting Autophagy.
Frontiers in pharmacology
Luo LF,Qin LY,Wang JX,Guan P,Wang N,Ji ES
Sat Jun 12 00:00:00 EDT 2021
CN-3 induces mitochondrial apoptosis in glioma via Ros-mediated PI3K/AKT pathway.
Die Pharmazie
Xue YY,Lu YY,Sun GQ,Fang F,Ji YQ,Tang HF,Qiu PC,Cheng G
Sat May 01 00:00:00 EDT 2021
Inhibition of Growth of Colon Tumors and Proliferation of HT-29 Cells by Warburgia ugandensis Extract through Mediating G0/G1 Cell Cycle Arrest, Cell Apoptosis, and Intracellular ROS Generation.
Oxidative medicine and cellular longevity
Zhang Y,Chen G,Zhuang X,Guo M
Fri Mar 04 00:00:00 EST 2022
[6]-Paradol suppresses proliferation and metastases of pancreatic cancer by decreasing EGFR and inactivating PI3K/AKT signaling.
Cancer cell international
Jiang X,Wang J,Chen P,He Z,Xu J,Chen Y,Liu X,Jiang J
Tue Aug 10 00:00:00 EDT 2021
IL-8 exacerbates alcohol-induced fatty liver disease via the Akt/HIF-1α pathway in human IL-8-expressing mice.
Cytokine
Wang Z,Li B,Jiang H,Ma Y,Bao Y,Zhu X,Xia H,Jin Y
Mon Feb 01 00:00:00 EST 2021
Exosomal ANXA2 derived from ovarian cancer cells regulates epithelial-mesenchymal plasticity of human peritoneal mesothelial cells.
Journal of cellular and molecular medicine
Gao L,Nie X,Gou R,Hu Y,Dong H,Li X,Lin B
Wed Dec 01 00:00:00 EST 2021
Design, synthesis, and biological evaluation of 2,4-diamino pyrimidine derivatives as potent FAK inhibitors with anti-cancer and anti-angiogenesis activities.
European journal of medicinal chemistry
Wang S,Zhang RH,Zhang H,Wang YC,Yang D,Zhao YL,Yan GY,Xu GB,Guan HY,Zhou YH,Cui DB,Liu T,Li YJ,Liao SG,Zhou M
Fri Oct 15 00:00:00 EDT 2021
Hawthorn polyphenols, D-chiro-inositol, and epigallocatechin gallate exert a synergistic hypoglycemic effect.
Journal of food biochemistry
Xin C,Zhao M,Wang J,Wang Z
Thu Jul 01 00:00:00 EDT 2021
Integrating Network Pharmacology and Experimental Verification to Explore the Mechanism of Effect of Zuojin Pills in Pancreatic Cancer Treatment.
Drug design, development and therapy
Wang K,Miao X,Kong F,Huang S,Mo J,Jin C,Zheng Y
Thu Jan 20 00:00:00 EST 2022
Nutrient metabolism in the liver and muscle of juvenile blunt snout bream (Megalobrama amblycephala) in response to dietary methionine levels.
Scientific reports
Ji K,Liang H,Ren M,Ge X,Pan L,Yu H
Mon Dec 13 00:00:00 EST 2021
Adiponectin Attenuates Lipopolysaccharide-induced Apoptosis by Regulating the Cx43/PI3K/AKT Pathway.
Frontiers in pharmacology
Liu L,Yan M,Yang R,Qin X,Chen L,Li L,Si J,Li X,Ma K
Sat Jun 05 00:00:00 EDT 2021
The protective effect of Metformin/Donepezil in diabetic mice brain: evidence from bioinformatics analysis and experiments.
European review for medical and pharmacological sciences
Hou Y,Li FZ
Wed Dec 01 00:00:00 EST 2021
NLRP3 promotes endometrial receptivity by inducing epithelial-mesenchymal transition of the endometrial epithelium.
Molecular human reproduction
Cheng X,Zhang Y,Ma J,Wang S,Ma R,Ge X,Zhao W,Xue T,Chen L,Yao B
Tue Nov 02 00:00:00 EDT 2021
Acupuncture regulates the autophagy of ovarian granulosa cells in polycystic ovarian syndrome ovulation disorder by inhibiting the PI3K/AKT/mTOR pathway through LncMEG3.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Chen X,Tang H,Liang Y,Wu P,Xie L,Ding Y,Yang P,Long B,Lin J
Wed Dec 01 00:00:00 EST 2021
Acupuncture regulates the autophagy of ovarian granulosa cells in polycystic ovarian syndrome ovulation disorder by inhibiting the PI3K/AKT/mTOR pathway through LncMEG3.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Chen X,Tang H,Liang Y,Wu P,Xie L,Ding Y,Yang P,Long B,Lin J
Wed Dec 01 00:00:00 EST 2021
Midkine promotes glioblastoma progression via PI3K-Akt signaling.
Cancer cell international
Hu B,Qin C,Li L,Wei L,Mo X,Fan H,Lei Y,Wei F,Zou D
Thu Sep 23 00:00:00 EDT 2021
Activation of microglial GLP-1R in the trigeminal nucleus caudalis suppresses central sensitization of chronic migraine after recurrent nitroglycerin stimulation.
The journal of headache and pain
Jing F,Zou Q,Wang Y,Cai Z,Tang Y
Thu Jul 29 00:00:00 EDT 2021
Transcriptome-Based Network Analysis Reveals Hirudin Potentiates Anti-Renal Fibrosis Efficacy in UUO Rats.
Frontiers in pharmacology
Yu HX,Lin W,Yang K,Wei LJ,Chen JL,Liu XY,Zhong K,Chen X,Pei M,Yang HT
Sat Oct 09 00:00:00 EDT 2021
Maternal High-Fat Diet Alters the Characteristics of Astrocytes and Worsens the Outcome of Stroke in Rat Offspring, Which Improves After FGF21 Administration.
Frontiers in cell and developmental biology
Li Y,Lin M,Lin P,Xia N,Li X,Lin L,Yang Y
Tue Feb 01 00:00:00 EST 2022
Three phytosterols from sweet potato inhibit MCF7-xenograft-tumor growth through modulating gut microbiota homeostasis and SCFAs secretion.
Food research international (Ottawa, Ont.)
Han B,Jiang P,Jiang L,Li X,Ye X
Mon Mar 01 00:00:00 EST 2021
QiShenYiQi pill activates autophagy to attenuate reactive myocardial fibrosis via the PI3K/AKT/mTOR pathway.
Aging
Lv S,Yuan P,Lu C,Dong J,Li M,Qu F,Zhu Y,Zhang J
Thu Feb 11 00:00:00 EST 2021
Taxifolin retards the D-galactose-induced aging process through inhibiting Nrf2-mediated oxidative stress and regulating the gut microbiota in mice.
Food & function
Liu XL,Zhao YC,Zhu HY,Wu M,Zheng YN,Yang M,Cheng ZQ,Ding CB,Liu WC
Mon Nov 29 00:00:00 EST 2021
S100A8 promotes chemoresistance via augmenting autophagy in B‑cell lymphoma cells.
Oncology reports
Zhang L,Zhou S,Zhou T,Yuan K,Li X,Tang J
Fri Jan 01 00:00:00 EST 2021
A rapid juvenile murine model of nonalcoholic steatohepatitis (NASH): Chronic intermittent hypoxia exacerbates Western diet-induced NASH.
Life sciences
Zhou J,Zhao Y,Guo YJ,Zhao YS,Liu H,Ren J,Li JR,Ji ES
Thu Jul 01 00:00:00 EDT 2021
A New Chalcone Derivative C49 Reverses Doxorubicin Resistance in MCF-7/DOX Cells by Inhibiting P-Glycoprotein Expression.
Frontiers in pharmacology
Wang T,Dong J,Yuan X,Wen H,Wu L,Liu J,Sui H,Deng W
Sun May 02 00:00:00 EDT 2021
Liver paraoxonase 3 expression and the effect of liraglutide treatment in a rat model of diabetes.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University
Liu Y,Zhu D,Dong G,Zeng Y,Jiang P,Xiao Y
Mon Feb 01 00:00:00 EST 2021
Baicalein Inhibits Gastric Cancer Cell Proliferation and Migration through a FAK Interaction via AKT/mTOR Signaling.
The American journal of Chinese medicine
Qiao D,Jin J,Xing J,Zhang Y,Jia N,Ren X,Lin Z,Jin N,Chen L,Piao Y
Thu Aug 26 00:00:00 EDT 2021
Combination effect of curcumin with docetaxel on the PI3K/AKT/mTOR pathway to induce autophagy and apoptosis in esophageal squamous cell carcinoma.
American journal of translational research
Deng L,Wu X,Zhu X,Yu Z,Liu Z,Wang J,Zheng Y
Wed Feb 03 00:00:00 EST 2021
Identification of Potentially Related Genes and Mechanisms Involved in Skeletal Muscle Atrophy Induced by Excessive Exercise in Zebrafish.
Biology
Sun CC,Zhou ZQ,Chen ZL,Zhu RK,Yang D,Peng XY,Zheng L,Tang CF
Tue Aug 10 00:00:00 EDT 2021
Methylation of NRN1 is a novel synthetic lethal marker of PI3K-Akt-mTOR and ATR inhibitors in esophageal cancer.
Cancer science
Du W,Gao A,Herman JG,Wang L,Zhang L,Jiao S,Guo M
Thu Jul 01 00:00:00 EDT 2021
Methylation of NRN1 is a novel synthetic lethal marker of PI3K-Akt-mTOR and ATR inhibitors in esophageal cancer.
Cancer science
Du W,Gao A,Herman JG,Wang L,Zhang L,Jiao S,Guo M
Thu Jul 01 00:00:00 EDT 2021
Exogenous hydrogen sulfide inhibits apoptosis by regulating endoplasmic reticulum stress-autophagy axis and improves myocardial reconstruction after acute myocardial infarction.
Acta biochimica et biophysica Sinica
Li Y,Liu M,Yi J,Song X,Zheng X,Liu D,Wang S,Chu C,Yang J
Tue Dec 29 00:00:00 EST 2020
Calcium relieves fluoride-induced bone damage through the PI3K/AKT pathway.
Food & function
Wang J,Xu H,Cheng X,Yang J,Yan Z,Ma H,Zhao Y,Ommati MM,Manthari RK,Wang J
Wed Jan 29 00:00:00 EST 2020
Targeting the miR-122/PKM2 autophagy axis relieves arsenic stress.
Journal of hazardous materials
Wang Y,Zhao H,Guo M,Fei D,Zhang L,Xing M
Wed Feb 05 00:00:00 EST 2020
LETM1 Promotes Gastric Cancer Cell Proliferation, Migration, and Invasion via the PI3K/Akt Signaling Pathway.
Journal of gastric cancer
Zhang Y,Chen L,Cao Y,Chen S,Xu C,Xing J,Zhang K
Mon Jun 01 00:00:00 EDT 2020
Oxymatrine protects neonatal rat against hypoxic-ischemic brain damage via PI3K/Akt/GSK3β pathway.
Life sciences
Liu Y,Wang H,Liu N,Du J,Lan X,Qi X,Zhuang C,Sun T,Li Y,Yu J
Sat Aug 01 00:00:00 EDT 2020
Polyphyllin VII induces apoptotic cell death via inhibition of the PI3K/Akt and NF‑κB pathways in A549 human lung cancer cells.
Molecular medicine reports
He H,Xu C,Zheng L,Wang K,Jin M,Sun Y,Yue Z
Sat Feb 01 00:00:00 EST 2020
Alginate oligosaccharide protects endothelial cells against oxidative stress injury via integrin-α/FAK/PI3K signaling.
Biotechnology letters
Zhao J,Han Y,Wang Z,Zhang R,Wang G,Mao Y
Tue Dec 01 00:00:00 EST 2020
Ethanol Extract of Brucea javanica Seed Inhibit Triple-Negative Breast Cancer by Restraining Autophagy via PI3K/Akt/mTOR Pathway.
Frontiers in pharmacology
Chen X,Li S,Li D,Li M,Su Z,Lai X,Zhou C,Chen S,Li S,Yang X,Su J,Zhang Y
Mon Sep 28 00:00:00 EDT 2020
miR-21-5p: A viable therapeutic strategy for regulating intraocular pressure.
Experimental eye research
Tan C,Song M,Stamer WD,Qiao Y,Chen X,Sun X,Lei Y,Chen J
Sun Nov 01 00:00:00 EDT 2020
Identification of Differentially Expressed Genes and Key Pathways in the Dorsal Root Ganglion After Chronic Compression.
Frontiers in molecular neuroscience
Du Z,Yin S,Song X,Zhang L,Yue S,Jia X,Zhang Y
Mon Sep 28 00:00:00 EDT 2020
Pomegranate flower extract bidirectionally regulates the proliferation, differentiation and apoptosis of 3T3-L1 cells through regulation of PPARγ expression mediated by PI3K-AKT signaling pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Li T,Zhang L,Jin C,Xiong Y,Cheng YY,Chen K
Sun Nov 01 00:00:00 EDT 2020
Organic anion transporters and PI3K-AKT-mTOR pathway mediate the synergistic anticancer effect of pemetrexed and rhein.
Journal of cellular physiology
Bu T,Wang C,Jin H,Meng Q,Huo X,Sun H,Sun P,Wu J,Ma X,Liu Z,Liu K
Wed Apr 01 00:00:00 EDT 2020
Inhibition of PDE4/PDE4B improves renal function and ameliorates inflammation in cisplatin-induced acute kidney injury.
American journal of physiology. Renal physiology
Xu M,Yu X,Meng X,Huang S,Zhang Y,Zhang A,Jia Z
Sun Mar 01 00:00:00 EST 2020
Zinc application alleviates the adverse renal effects of arsenic stress in a protein quality control way in common carp.
Environmental research
Wang Y,Zhao H,Nie X,Guo M,Jiang G,Xing M
Tue Dec 01 00:00:00 EST 2020
LukS-PV Inhibits Hepatocellular Carcinoma Cells Migration via the TNNC1/PI3K/AKT Axis.
OncoTargets and therapy
Ma F,Wang Z,Qiang Y,Xu L,Ding P,Wang Y,Ma X
Sun Apr 17 00:00:00 EDT 2022
HOXC10 promotes proliferation and attenuates lipid accumulation of sheep bone marrow mesenchymal stem cells.
Molecular and cellular probes
Ma M,Wang C,Ao Y,He N,Hao F,Liang H,Liu D
Sat Feb 01 00:00:00 EST 2020
Lycium barbarum polysaccharide protects against Homocysteine-induced Vascular smooth muscle cell proliferation and phenotypic transformation via PI3K/Akt pathway.
Journal of molecular histology
Zhang M,Li F,Pokharel S,Ma T,Wang X,Wang Y,Wang W,Lin R
Tue Dec 01 00:00:00 EST 2020
LINC00680 and TTN-AS1 Stabilized by EIF4A3 Promoted Malignant Biological Behaviors of Glioblastoma Cells.
Molecular therapy. Nucleic acids
Tang W,Wang D,Shao L,Liu X,Zheng J,Xue Y,Ruan X,Yang C,Liu L,Ma J,Li Z,Liu Y
Fri Mar 06 00:00:00 EST 2020
Effective-component compatibility of Bufei Yishen formula II inhibits mucus hypersecretion of chronic obstructive pulmonary disease rats by regulating EGFR/PI3K/mTOR signaling.
Journal of ethnopharmacology
Li J,Ma J,Tian Y,Zhao P,Liu X,Dong H,Zheng W,Feng S,Zhang L,Wu M,Zhu L,Liu S,Zhao D
Wed Jul 15 00:00:00 EDT 2020
Emodin Alleviates Hydrogen Peroxide-Induced Inflammation and Oxidative Stress via Mitochondrial Dysfunction by Inhibiting the PI3K/mTOR/GSK3β Pathway in Neuroblastoma SH-SY5Y Cells.
BioMed research international
Li R,Liu W,Ou L,Gao F,Li M,Wang L,Wei P,Miao F
Fri Apr 23 00:00:00 EDT 2021
Overexpression of Mucin 1 Suppresses the Therapeutical Efficacy of Disulfiram against Canine Mammary Tumor.
Animals : an open access journal from MDPI
Zhao Y,Lin Z,Lin Z,Zhou C,Liu G,Lin J,Zhang D,Lin D
Sun Dec 27 00:00:00 EST 2020
Overexpression of Mucin 1 Suppresses the Therapeutical Efficacy of Disulfiram against Canine Mammary Tumor.
Animals : an open access journal from MDPI
Zhao Y,Lin Z,Lin Z,Zhou C,Liu G,Lin J,Zhang D,Lin D
Sun Dec 27 00:00:00 EST 2020
Par6 regulates cell cycle progression through enhancement of Akt/PI3K/GSK-3β signaling pathway activation in glioma.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Liu P,Zhu C,Luo J,Lan S,Su D,Wang Q,Wei Z,Cui W,Xu C,Yang X
Wed Jan 01 00:00:00 EST 2020
Par6 regulates cell cycle progression through enhancement of Akt/PI3K/GSK-3β signaling pathway activation in glioma.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Liu P,Zhu C,Luo J,Lan S,Su D,Wang Q,Wei Z,Cui W,Xu C,Yang X
Wed Jan 01 00:00:00 EST 2020
AMPH1 functions as a tumour suppressor in ovarian cancer via the inactivation of PI3K/AKT pathway.
Journal of cellular and molecular medicine
Chen Y,Cao W,Wang L,Zhong T
Wed Jul 01 00:00:00 EDT 2020
METTL14 Inhibits Hepatocellular Carcinoma Metastasis Through Regulating EGFR/PI3K/AKT Signaling Pathway in an m6A-Dependent Manner.
Cancer management and research
Shi Y,Zhuang Y,Zhang J,Chen M,Wu S
Tue Apr 19 00:00:00 EDT 2022
MTH1 Inhibitor TH287 Suppresses Gastric Cancer Development Through the Regulation of PI3K/AKT Signaling.
Cancer biotherapy & radiopharmaceuticals
Zhan D,Zhang X,Li J,Ding X,Cui Y,Jia J
Wed Apr 01 00:00:00 EDT 2020
MNAT1 promotes proliferation and the chemo-resistance of osteosarcoma cell to cisplatin through regulating PI3K/Akt/mTOR pathway.
BMC cancer
Qiu C,Su W,Shen N,Qi X,Wu X,Wang K,Li L,Guo Z,Tao H,Wang G,Chen B,Xiang H
Thu Dec 03 00:00:00 EST 2020
Paecilomyces cicadae-fermented Radix astragali activates podocyte autophagy by attenuating PI3K/AKT/mTOR pathways to protect against diabetic nephropathy in mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Yang F,Qu Q,Zhao C,Liu X,Yang P,Li Z,Han L,Shi X
Tue Sep 01 00:00:00 EDT 2020
Luteolin alleviates methamphetamine-induced neurotoxicity by suppressing PI3K/Akt pathway-modulated apoptosis and autophagy in rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Tan XH,Zhang KK,Xu JT,Qu D,Chen LJ,Li JH,Wang Q,Wang HJ,Xie XL
Sun Mar 01 00:00:00 EST 2020
Britanin Exhibits Potential Inhibitory Activity on Human Prostate Cancer Cell Lines Through PI3K/Akt/NF-κB Signaling Pathways.
Planta medica
Zeng Q,Zeng Y,Nie X,Guo Y,Zhan Y
Tue Dec 01 00:00:00 EST 2020
Proanthocyanidin B2 inhibits proliferation and induces apoptosis of osteosarcoma cells by suppressing the PI3K/AKT pathway.
Journal of cellular and molecular medicine
Wu X,Yu H,Zhou H,Li Z,Huang H,Xiao F,Xu S,Yang Y
Thu Oct 01 00:00:00 EDT 2020
Bta-miR-223 Targeting CBLB Contributes to Resistance to Staphylococcus aureus Mastitis Through the PI3K/AKT/NF-κB Pathway.
Frontiers in veterinary science
Han S,Li X,Liu J,Zou Z,Luo L,Wu R,Zhao Z,Wang C,Shen B
Tue Nov 17 00:00:00 EST 2020
Effects of Hydrogen-rich Water on the PI3K/AKT Signaling Pathway in Rats with Myocardial Ischemia-reperfusion Injury.
Current molecular medicine
Li L,Li X,Zhang Z,Liu L,Liu T,Li S,Liu S,Zhou Y,Liu F
Wed Jun 09 00:00:00 EDT 2021
Protective Effects of Combination of Radix Astragali and Radix Salviae Miltiorrhizae on Kidney of Spontaneously Hypertensive Rats and Renal Intrinsic Cells.
Chinese journal of integrative medicine
Li W,Jiang YH,Wang Y,Zhao M,Hou GJ,Hu HZ,Zhou L
Wed Jan 01 00:00:00 EST 2020
Dihydromethysticin, a natural molecule from Kava, suppresses the growth of colorectal cancer via the NLRC3/PI3K pathway.
Molecular carcinogenesis
Pan H,Liu F,Wang J,Zhao M,Wang D,Jia C,Wang T,Chen Z,Fan Y,Liang D,Meng Q
Mon Jun 01 00:00:00 EDT 2020
MiR-145 alleviates Hcy-induced VSMC proliferation, migration, and phenotypic switch through repression of the PI3K/Akt/mTOR pathway.
Histochemistry and cell biology
Zhang M,Li F,Wang X,Gong J,Xian Y,Wang G,Zheng Z,Shang C,Wang B,He Y,Wang W,Lin R
Fri May 01 00:00:00 EDT 2020
Deciphering the Pharmacological Mechanisms of Taohe-Chengqi Decoction Extract Against Renal Fibrosis Through Integrating Network Pharmacology and Experimental Validation In Vitro and In Vivo.
Frontiers in pharmacology
Zhou S,Ai Z,Li W,You P,Wu C,Li L,Hu Y,Ba Y
Mon Sep 28 00:00:00 EDT 2020
LncRNA AY343892 inhibits breast cancer development by positively regulating BRCA1-mediated transcription of PTEN.
Histology and histopathology
Li Y,Zhang M,Li F
Thu Oct 01 00:00:00 EDT 2020
Pyrroline-5-carboxylate reductase 1 (PYCR1) upregulation contributes to gastric cancer progression and indicates poor survival outcome.
Annals of translational medicine
Xiao S,Li S,Yuan Z,Zhou L
Sat Aug 01 00:00:00 EDT 2020
Eurocristatine, a plant alkaloid from Eurotium cristatum, alleviates insulin resistance in db/db diabetic mice via activation of PI3K/AKT signaling pathway.
European journal of pharmacology
Zhang H,Hui J,Yang J,Deng J,Fan D
Sun Nov 15 00:00:00 EST 2020
Eurocristatine, a plant alkaloid from Eurotium cristatum, alleviates insulin resistance in db/db diabetic mice via activation of PI3K/AKT signaling pathway.
European journal of pharmacology
Zhang H,Hui J,Yang J,Deng J,Fan D
Sun Nov 15 00:00:00 EST 2020
Eurocristatine, a plant alkaloid from Eurotium cristatum, alleviates insulin resistance in db/db diabetic mice via activation of PI3K/AKT signaling pathway.
European journal of pharmacology
Zhang H,Hui J,Yang J,Deng J,Fan D
Sun Nov 15 00:00:00 EST 2020
Eurocristatine, a plant alkaloid from Eurotium cristatum, alleviates insulin resistance in db/db diabetic mice via activation of PI3K/AKT signaling pathway.
European journal of pharmacology
Zhang H,Hui J,Yang J,Deng J,Fan D
Sun Nov 15 00:00:00 EST 2020
Velvet antler polypeptide prevents the disruption of hepatic tight junctions via inhibiting oxidative stress in cholestatic mice and liver cell lines.
Food & function
Li L,Yang F,Jia R,Yan P,Ma L
Wed Nov 18 00:00:00 EST 2020
miR-7-5p Affects Brain Edema After Intracerebral Hemorrhage and Its Possible Mechanism.
Frontiers in cell and developmental biology
Chen X,Deng S,Lei Q,He Q,Ren Y,Zhang Y,Nie J,Lu W
Tue Jan 05 00:00:00 EST 2021
Berberine inhibits proliferation and induces G0/G1 phase arrest in colorectal cancer cells by downregulating IGF2BP3.
Life sciences
Zhang Y,Liu X,Yu M,Xu M,Xiao Y,Ma W,Huang L,Li X,Ye X
Sun Nov 01 00:00:00 EDT 2020
Epigenetic silencing of IGFBPL1 promotes esophageal cancer growth by activating PI3K-AKT signaling.
Clinical epigenetics
Liu Y,Zhang M,He T,Yang W,Wang L,Zhang L,Guo M
Mon Feb 10 00:00:00 EST 2020
Epigenetic silencing of IGFBPL1 promotes esophageal cancer growth by activating PI3K-AKT signaling.
Clinical epigenetics
Liu Y,Zhang M,He T,Yang W,Wang L,Zhang L,Guo M
Mon Feb 10 00:00:00 EST 2020
Epigenetic silencing of IGFBPL1 promotes esophageal cancer growth by activating PI3K-AKT signaling.
Clinical epigenetics
Liu Y,Zhang M,He T,Yang W,Wang L,Zhang L,Guo M
Mon Feb 10 00:00:00 EST 2020
Epigenetic silencing of IGFBPL1 promotes esophageal cancer growth by activating PI3K-AKT signaling.
Clinical epigenetics
Liu Y,Zhang M,He T,Yang W,Wang L,Zhang L,Guo M
Mon Feb 10 00:00:00 EST 2020
Cetuximab enhances oridonin-induced apoptosis through mitochondrial pathway and endoplasmic reticulum stress in laryngeal squamous cell carcinoma cells.
Toxicology in vitro : an international journal published in association with BIBRA
Kang N,Cao S,Jiang B,Zhang Q,Donkor PO,Zhu Y,Qiu F,Gao X
Tue Sep 01 00:00:00 EDT 2020
S119N Mutation of the E3 Ubiquitin Ligase SPOP Suppresses SLC7A1 Degradation to Regulate Hepatoblastoma Progression.
Molecular therapy oncolytics
He W,Zhang J,Liu B,Liu X,Liu G,Xie L,He J,Wei M,Li K,Ma J,Dong R,Ma D,Dong K,Ye M
Wed Dec 16 00:00:00 EST 2020
TBHQ Attenuates Neurotoxicity Induced by Methamphetamine in the VTA through the Nrf2/HO-1 and PI3K/AKT Signaling Pathways.
Oxidative medicine and cellular longevity
Meng X,Zhang C,Guo Y,Han Y,Wang C,Chu H,Kong L,Ma H
Thu Feb 04 00:00:00 EST 2021
Protective effect of astaxanthin against La2O3 nanoparticles induced neurotoxicity by activating PI3K/AKT/Nrf-2 signaling in mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Yuan L,Qu Y,Li Q,An T,Chen Z,Chen Y,Deng X,Bai D
Thu Oct 01 00:00:00 EDT 2020
Curcumin metabolites contribute to the effect of curcumin on ameliorating insulin sensitivity in high-glucose-induced insulin-resistant HepG2 cells.
Journal of ethnopharmacology
Li P,Ding L,Cao S,Feng X,Zhang Q,Chen Y,Zhang N,Qiu F
Tue Sep 15 00:00:00 EDT 2020
miR-222 Suppresses Immature Porcine Sertoli Cell Growth by Targeting the GRB10 Gene Through Inactivating the PI3K/AKT Signaling Pathway.
Frontiers in genetics
Luo H,Peng F,Weng B,Tang X,Chen Y,Yang A,Chen B,Ran M
Fri Dec 18 00:00:00 EST 2020
The Preparation of Ginsenoside Rg5, Its Antitumor Activity against Breast Cancer Cells and Its Targeting of PI3K.
Nutrients
Liu Y,Fan D
Sat Jan 18 00:00:00 EST 2020
Daucosterol linolenate from Sweet Potato Suppresses MCF7-Xenograft-Tumor Growth through Regulating PI3K/AKT Pathway.
Planta medica
Han B,Jiang L,Jiang P,Zhou D,Jia X,Li X,Ye X
Wed Jul 01 00:00:00 EDT 2020
Daucosterol linolenate from Sweet Potato Suppresses MCF7-Xenograft-Tumor Growth through Regulating PI3K/AKT Pathway.
Planta medica
Han B,Jiang L,Jiang P,Zhou D,Jia X,Li X,Ye X
Wed Jul 01 00:00:00 EDT 2020
Chaiyu-Dixian Formula Exerts Protective Effects on Ovarian Follicular Abnormal Development in Chronic Unpredictable Mild Stress (CUMS) Rat Model.
Frontiers in pharmacology
Xu HX,Lin SX,Gong Y,Huo ZX,Zhao CY,Zhu HM,Xi SY
Wed Apr 13 00:00:00 EDT 2022
Dietary leucine affects glucose metabolism and lipogenesis involved in TOR/PI3K/Akt signaling pathway for juvenile blunt snout bream Megalobrama amblycephala.
Fish physiology and biochemistry
Liang H,Mokrani A,Chisomo-Kasiya H,Ji K,Ge X,Ren M,Liu B,Xi B,Sun A
Mon Apr 01 00:00:00 EDT 2019
Dietary leucine affects glucose metabolism and lipogenesis involved in TOR/PI3K/Akt signaling pathway for juvenile blunt snout bream Megalobrama amblycephala.
Fish physiology and biochemistry
Liang H,Mokrani A,Chisomo-Kasiya H,Ji K,Ge X,Ren M,Liu B,Xi B,Sun A
Mon Apr 01 00:00:00 EDT 2019
Astragaloside IV Regulates the PI3K/Akt/HO-1 Signaling Pathway and Inhibits H9c2 Cardiomyocyte Injury Induced by Hypoxia-Reoxygenation.
Biological & pharmaceutical bulletin
Yang P,Zhou Y,Xia Q,Yao L,Chang X
Wed May 01 00:00:00 EDT 2019
Secalonic Acid-F, a Novel Mycotoxin, Represses the Progression of Hepatocellular Carcinoma via MARCH1 Regulation of the PI3K/AKT/β-catenin Signaling Pathway.
Molecules (Basel, Switzerland)
Xie L,Li M,Liu D,Wang X,Wang P,Dai H,Yang W,Liu W,Hu X,Zhao M
Tue Jan 22 00:00:00 EST 2019
Dietary resveratrol supplementation inhibits heat stress-induced high-activated innate immunity and inflammatory response in spleen of yellow-feather broilers.
Poultry science
He S,Yu Q,He Y,Hu R,Xia S,He J
Sun Dec 01 00:00:00 EST 2019
MMP13 inhibition rescues cognitive decline in Alzheimer transgenic mice via BACE1 regulation.
Brain : a journal of neurology
Zhu BL,Long Y,Luo W,Yan Z,Lai YJ,Zhao LG,Zhou WH,Wang YJ,Shen LL,Liu L,Deng XJ,Wang XF,Sun F,Chen GJ
Tue Jan 01 00:00:00 EST 2019
Nano-Gold Loaded with Resveratrol Enhance the Anti-Hepatoma Effect of Resveratrol In Vitro and In Vivo.
Journal of biomedical nanotechnology
Zhang D,Zhang J,Zeng J,Li Z,Zuo H,Huang C,Zhao X
Fri Feb 01 00:00:00 EST 2019
Dihydroartemisinin attenuates renal fibrosis through regulation of fibroblast proliferation and differentiation.
Life sciences
Zhang B,Liu P,Zhou Y,Chen Z,He Y,Mo M,Dai G,Xia W,Du Y,Liu Y,Chen X
Mon Apr 15 00:00:00 EDT 2019
Protease-activated receptor 2 (PAR-2) antagonist AZ3451 as a novel therapeutic agent for osteoarthritis.
Aging
Huang X,Ni B,Xi Y,Chu X,Zhang R,You H
Mon Dec 16 00:00:00 EST 2019
Sinulariolide Inhibits Gastric Cancer Cell Migration and Invasion through Downregulation of the EMT Process and Suppression of FAK/PI3K/AKT/mTOR and MAPKs Signaling Pathways.
Marine drugs
Wu YJ,Lin SH,Din ZH,Su JH,Liu CI
Wed Nov 27 00:00:00 EST 2019
Umbilical Cord Blood Mesenchymal Stem Cells Enhance Lipopolysaccharide-Induced IL-10 and IL-37 Production in THP-1 Cells.
Inflammation
Zhou T,Sun Y,Wang Y,Chen X,Zhuo L,Bu L,Xu S,Han J,Li X,Shi J
Sat Jun 01 00:00:00 EDT 2019
Resveratrol prevents chronic intermittent hypoxia-induced cardiac hypertrophy by targeting the PI3K/AKT/mTOR pathway.
Life sciences
Guan P,Sun ZM,Wang N,Zhou J,Luo LF,Zhao YS,Ji ES
Sun Sep 15 00:00:00 EDT 2019
MARCH1 encourages tumour progression of hepatocellular carcinoma via regulation of PI3K-AKT-β-catenin pathways.
Journal of cellular and molecular medicine
Xie L,Dai H,Li M,Yang W,Yu G,Wang X,Wang P,Liu W,Hu X,Zhao M
Wed May 01 00:00:00 EDT 2019
High expression of ubiquitin carboxyl-terminal hydrolase 22 is associated with poor prognosis in hepatitis B virus-associated liver cancer.
Oncology letters
Liao Y,Liang X,Liang W,Li Z,Wang Y,Wang L,Zhen S,Tang B,Wang Z
Sat Jun 01 00:00:00 EDT 2019
Protective role of thymoquinone in sepsis-induced liver injury in BALB/c mice.
Experimental and therapeutic medicine
Wang F,Lei X,Zhao Y,Yu Q,Li Q,Zhao H,Pei Z
Sun Sep 01 00:00:00 EDT 2019
Fibroblast growth factor-21 alleviates hypoxia/reoxygenation injury in H9c2 cardiomyocytes by promoting autophagic flux.
International journal of molecular medicine
Ren Z,Xiao W,Zeng Y,Liu MH,Li GH,Tang ZH,Qu SL,Hao YM,Yuan HQ,Jiang ZS
Fri Mar 01 00:00:00 EST 2019
Role of Tim-3 in Decidual Macrophage Functional Polarization During Abnormal Pregnancy With Toxoplasma gondii Infection.
Frontiers in immunology
Zhang D,Ren L,Zhao M,Yang C,Liu X,Zhang H,Jiang Y,Sun X,Li T,Cui L,Hu X
Thu Oct 15 00:00:00 EDT 2020
Retinol binding protein 4 mediates MEHP-induced glucometabolic abnormalities in HepG2 cells.
Toxicology
Wang F,Chang C,Li R,Zhang Z,Jiang H,Zeng N,Li D,Chen L,Xiao Y,Chen W,Wang Q
Thu Aug 01 00:00:00 EDT 2019
Correlation between microbes and colorectal cancer: tumor apoptosis is induced by sitosterols through promoting gut microbiota to produce short-chain fatty acids.
Apoptosis : an international journal on programmed cell death
Ma H,Yu Y,Wang M,Li Z,Xu H,Tian C,Zhang J,Ye X,Li X
Fri Feb 01 00:00:00 EST 2019
Palmitic Acid Induces MicroRNA-221 Expression to Decrease Glucose Uptake in HepG2 Cells via the PI3K/AKT/GLUT4 Pathway.
BioMed research international
Huang F,Chen J,Wang J,Zhu P,Lin W
Mon Apr 20 00:00:00 EDT 2020
Involvement of the PI3K/Akt/Nrf2 Signaling Pathway in Resveratrol-Mediated Reversal of Drug Resistance in HL-60/ADR Cells.
Nutrition and cancer
Li Y,Guo Y,Feng Z,Bergan R,Li B,Qin Y,Zhao L,Zhang Z,Shi M
Mon Jun 01 00:00:00 EDT 2020
Cystathionine‑γ‑lyase promotes the metastasis of breast cancer via the VEGF signaling pathway.
International journal of oncology
Wang L,Shi H,Liu Y,Zhang W,Duan X,Li M,Shi X,Wang T
Thu Aug 01 00:00:00 EDT 2019
NOV/CCN3 induces cartilage protection by inhibiting PI3K/AKT/mTOR pathway.
Journal of cellular and molecular medicine
Huang X,Ni B,Mao Z,Xi Y,Chu X,Zhang R,Ma X,You H
Fri Nov 01 00:00:00 EDT 2019
Visfatin Plays a Significant Role in Alleviating Lipopolysaccharide-Induced Apoptosis and Autophagy Through PI3K/AKT Signaling Pathway During Acute Lung Injury in Mice.
Archivum immunologiae et therapiae experimentalis
Wu XT,Ansari AR,Pang XX,Li HZ,Zhang ZW,Luo Y,Arshad M,Song H
Thu Aug 01 00:00:00 EDT 2019
Rice Protein Exerts Anti-Inflammatory Effect in Growing and Adult Rats via Suppressing NF-κB Pathway.
International journal of molecular sciences
Wang Z,Liang M,Li H,Cai L,Yang L
Fri Dec 06 00:00:00 EST 2019
Leucine attenuates muscle atrophy and autophagosome formation by activating PI3K/AKT/mTOR signaling pathway in rotator cuff tears.
Cell and tissue research
Zheng R,Huang S,Zhu J,Lin W,Xu H,Zheng X
Tue Oct 01 00:00:00 EDT 2019
Pharmacological actions of neferine in the modulation of human platelet function.
European journal of pharmacology
Yang RP,Zhou YJ,Song W,Yin Z,He AD,Ming ZY
Tue Nov 05 00:00:00 EST 2019
Aspirin inhibits adipogenesis of tendon stem cells and lipids accumulation in rat injury tendon through regulating PTEN/PI3K/AKT signalling.
Journal of cellular and molecular medicine
Wang Y,He G,Wang F,Zhang C,Ge Z,Zheng X,Deng H,Yuan C,Zhou B,Tao X,Zhang J,Tang K
Fri Nov 01 00:00:00 EDT 2019
The cardiotoxicity of the common carp (Cyprinus carpio) exposed to environmentally relevant concentrations of arsenic and subsequently relieved by zinc supplementation.
Environmental pollution (Barking, Essex : 1987)
Zhao H,Wang Y,Liu J,Guo M,Fei D,Yu H,Xing M
Tue Oct 01 00:00:00 EDT 2019
Inhibition of MCF-7 breast cancer cell proliferation by a synthetic peptide derived from the C-terminal sequence of Orai channel.
Biochemical and biophysical research communications
Li S,Yao M,Niu C,Liu D,Tang Z,Gu C,Zhao H,Ke J,Wu S,Wang X,Wu F
Tue Sep 03 00:00:00 EDT 2019
Destruction of redox and mitochondrial dynamics co-contributes to programmed cell death in chicken kidney under arsenite or/and copper (II) exposure.
Ecotoxicology and environmental safety
Zhao H,Wang Y,Fei D,Guo M,Yang X,Mu M,Yu H,Xing M
Sun Sep 15 00:00:00 EDT 2019
STAT3/HOTAIR Signaling Axis Regulates HNSCC Growth in an EZH2-dependent Manner.
Clinical cancer research : an official journal of the American Association for Cancer Research
Sun S,Wu Y,Guo W,Yu F,Kong L,Ren Y,Wang Y,Yao X,Jing C,Zhang C,Liu M,Zhang Y,Zhao M,Li Z,Wu C,Qiao Y,Yang J,Wang X,Zhang L,Li M,Zhou X
Fri Jun 01 00:00:00 EDT 2018
STAT3/HOTAIR Signaling Axis Regulates HNSCC Growth in an EZH2-dependent Manner.
Clinical cancer research : an official journal of the American Association for Cancer Research
Sun S,Wu Y,Guo W,Yu F,Kong L,Ren Y,Wang Y,Yao X,Jing C,Zhang C,Liu M,Zhang Y,Zhao M,Li Z,Wu C,Qiao Y,Yang J,Wang X,Zhang L,Li M,Zhou X
Fri Jun 01 00:00:00 EDT 2018
STAT3/HOTAIR Signaling Axis Regulates HNSCC Growth in an EZH2-dependent Manner.
Clinical cancer research : an official journal of the American Association for Cancer Research
Sun S,Wu Y,Guo W,Yu F,Kong L,Ren Y,Wang Y,Yao X,Jing C,Zhang C,Liu M,Zhang Y,Zhao M,Li Z,Wu C,Qiao Y,Yang J,Wang X,Zhang L,Li M,Zhou X
Fri Jun 01 00:00:00 EDT 2018
STAT3/HOTAIR Signaling Axis Regulates HNSCC Growth in an EZH2-dependent Manner.
Clinical cancer research : an official journal of the American Association for Cancer Research
Sun S,Wu Y,Guo W,Yu F,Kong L,Ren Y,Wang Y,Yao X,Jing C,Zhang C,Liu M,Zhang Y,Zhao M,Li Z,Wu C,Qiao Y,Yang J,Wang X,Zhang L,Li M,Zhou X
Fri Jun 01 00:00:00 EDT 2018
An Efficient Bivalent Cyclic RGD-PIK3CB siRNA Conjugate for Specific Targeted Therapy against Glioblastoma In Vitro and In Vivo.
Molecular therapy. Nucleic acids
Cen B,Wei Y,Huang W,Teng M,He S,Li J,Wang W,He G,Bai X,Liu X,Yuan Y,Pan X,Ji A
Fri Dec 07 00:00:00 EST 2018
An Efficient Bivalent Cyclic RGD-PIK3CB siRNA Conjugate for Specific Targeted Therapy against Glioblastoma In Vitro and In Vivo.
Molecular therapy. Nucleic acids
Cen B,Wei Y,Huang W,Teng M,He S,Li J,Wang W,He G,Bai X,Liu X,Yuan Y,Pan X,Ji A
Fri Dec 07 00:00:00 EST 2018
An Efficient Bivalent Cyclic RGD-PIK3CB siRNA Conjugate for Specific Targeted Therapy against Glioblastoma In Vitro and In Vivo.
Molecular therapy. Nucleic acids
Cen B,Wei Y,Huang W,Teng M,He S,Li J,Wang W,He G,Bai X,Liu X,Yuan Y,Pan X,Ji A
Fri Dec 07 00:00:00 EST 2018
An Efficient Bivalent Cyclic RGD-PIK3CB siRNA Conjugate for Specific Targeted Therapy against Glioblastoma In Vitro and In Vivo.
Molecular therapy. Nucleic acids
Cen B,Wei Y,Huang W,Teng M,He S,Li J,Wang W,He G,Bai X,Liu X,Yuan Y,Pan X,Ji A
Fri Dec 07 00:00:00 EST 2018
Migration inhibition of water stress proteins from Nostoc commune Vauch. via activation of autophagy in DLD-1 cells.
International journal of biological macromolecules
Guo S,Liang X,Guo M,Zhang X,Li Z
Thu Nov 01 00:00:00 EDT 2018
Migration inhibition of water stress proteins from Nostoc commune Vauch. via activation of autophagy in DLD-1 cells.
International journal of biological macromolecules
Guo S,Liang X,Guo M,Zhang X,Li Z
Thu Nov 01 00:00:00 EDT 2018
Osthole inhibits the PI3K/AKT signaling pathway via activation of PTEN and induces cell cycle arrest and apoptosis in esophageal squamous cell carcinoma.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Zhu X,Li Z,Li T,Long F,Lv Y,Liu L,Liu X,Zhan Q
Fri Jun 01 00:00:00 EDT 2018
Osthole inhibits the PI3K/AKT signaling pathway via activation of PTEN and induces cell cycle arrest and apoptosis in esophageal squamous cell carcinoma.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Zhu X,Li Z,Li T,Long F,Lv Y,Liu L,Liu X,Zhan Q
Fri Jun 01 00:00:00 EDT 2018
8-Cetylberberine inhibits growth of lung cancer in vitro and in vivo.
Life sciences
Xiao Y,Tian C,Huang T,Han B,Wang M,Ma H,Li Z,Ye X,Li X
Mon Jan 01 00:00:00 EST 2018
8-Cetylberberine inhibits growth of lung cancer in vitro and in vivo.
Life sciences
Xiao Y,Tian C,Huang T,Han B,Wang M,Ma H,Li Z,Ye X,Li X
Mon Jan 01 00:00:00 EST 2018
LncRNA TDRG1 enhances tumorigenicity in endometrial carcinoma by binding and targeting VEGF-A protein.
Biochimica et biophysica acta. Molecular basis of disease
Chen S,Wang LL,Sun KX,Liu Y,Guan X,Zong ZH,Zhao Y
Sat Sep 01 00:00:00 EDT 2018
LncRNA TDRG1 enhances tumorigenicity in endometrial carcinoma by binding and targeting VEGF-A protein.
Biochimica et biophysica acta. Molecular basis of disease
Chen S,Wang LL,Sun KX,Liu Y,Guan X,Zong ZH,Zhao Y
Sat Sep 01 00:00:00 EDT 2018
Ginsenoside Rg5 induces apoptosis and autophagy via the inhibition of the PI3K/Akt pathway against breast cancer in a mouse model.
Food & function
Liu Y,Fan D
Wed Nov 14 00:00:00 EST 2018
Ginsenoside Rg5 induces apoptosis and autophagy via the inhibition of the PI3K/Akt pathway against breast cancer in a mouse model.
Food & function
Liu Y,Fan D
Wed Nov 14 00:00:00 EST 2018
Ginsenoside Rg5 induces apoptosis and autophagy via the inhibition of the PI3K/Akt pathway against breast cancer in a mouse model.
Food & function
Liu Y,Fan D
Wed Nov 14 00:00:00 EST 2018
Ginsenoside Rg5 induces apoptosis and autophagy via the inhibition of the PI3K/Akt pathway against breast cancer in a mouse model.
Food & function
Liu Y,Fan D
Wed Nov 14 00:00:00 EST 2018
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
International immunopharmacology
Jia YN,Lu HP,Peng YL,Zhang BS,Gong XB,Su J,Zhou Y,Pan MH,Xu L
Thu Mar 01 00:00:00 EST 2018
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
International immunopharmacology
Jia YN,Lu HP,Peng YL,Zhang BS,Gong XB,Su J,Zhou Y,Pan MH,Xu L
Thu Mar 01 00:00:00 EST 2018
4'-hydroxywogonin inhibits colorectal cancer angiogenesis by disrupting PI3K/AKT signaling.
Chemico-biological interactions
Sun D,Zhang F,Qian J,Shen W,Fan H,Tan J,Li L,Xu C,Yang Y,Cheng H
Tue Dec 25 00:00:00 EST 2018
4'-hydroxywogonin inhibits colorectal cancer angiogenesis by disrupting PI3K/AKT signaling.
Chemico-biological interactions
Sun D,Zhang F,Qian J,Shen W,Fan H,Tan J,Li L,Xu C,Yang Y,Cheng H
Tue Dec 25 00:00:00 EST 2018
Inhibition of GLUT-1 expression and the PI3K/Akt pathway to enhance the chemosensitivity of laryngeal carcinoma cells in vitro.
OncoTargets and therapy
Jiang T,Zhou ML,Fan J
Wed Mar 30 00:00:00 EDT 2022
Inhibition of GLUT-1 expression and the PI3K/Akt pathway to enhance the chemosensitivity of laryngeal carcinoma cells in vitro.
OncoTargets and therapy
Jiang T,Zhou ML,Fan J
Wed Mar 30 00:00:00 EDT 2022
Synergistic effect of copper and arsenic upon oxidative stress, inflammation and autophagy alterations in brain tissues of Gallus gallus.
Journal of inorganic biochemistry
Sun X,Li J,Zhao H,Wang Y,Liu J,Shao Y,Xue Y,Xing M
Mon Jan 01 00:00:00 EST 2018
Synergistic effect of copper and arsenic upon oxidative stress, inflammation and autophagy alterations in brain tissues of Gallus gallus.
Journal of inorganic biochemistry
Sun X,Li J,Zhao H,Wang Y,Liu J,Shao Y,Xue Y,Xing M
Mon Jan 01 00:00:00 EST 2018
Dibutyl phthalate exposure aggravates type 2 diabetes by disrupting the insulin-mediated PI3K/AKT signaling pathway.
Toxicology letters
Deng T,Zhang Y,Wu Y,Ma P,Duan J,Qin W,Yang X,Chen M
Fri Jun 15 00:00:00 EDT 2018
Dibutyl phthalate exposure aggravates type 2 diabetes by disrupting the insulin-mediated PI3K/AKT signaling pathway.
Toxicology letters
Deng T,Zhang Y,Wu Y,Ma P,Duan J,Qin W,Yang X,Chen M
Fri Jun 15 00:00:00 EDT 2018
Osteopontin is essential for IL-1β production and apoptosis in peri-implantitis.
Clinical implant dentistry and related research
Che C,Liu J,Yang J,Ma L,Bai N,Zhang Q
Fri Jun 01 00:00:00 EDT 2018
Osteopontin is essential for IL-1β production and apoptosis in peri-implantitis.
Clinical implant dentistry and related research
Che C,Liu J,Yang J,Ma L,Bai N,Zhang Q
Fri Jun 01 00:00:00 EDT 2018
Formononetin inhibits colon carcinoma cell growth and invasion by microRNA‑149‑mediated EphB3 downregulation and inhibition of PI3K/AKT and STAT3 signaling pathways.
Molecular medicine reports
Wang AL,Li Y,Zhao Q,Fan LQ
Fri Jun 01 00:00:00 EDT 2018
Formononetin inhibits colon carcinoma cell growth and invasion by microRNA‑149‑mediated EphB3 downregulation and inhibition of PI3K/AKT and STAT3 signaling pathways.
Molecular medicine reports
Wang AL,Li Y,Zhao Q,Fan LQ
Fri Jun 01 00:00:00 EDT 2018
Brg1 aggravates airway inflammation in asthma via inhibition of the PI3K/Akt/mTOR pathway.
Biochemical and biophysical research communications
Zou W,Ding F,Niu C,Fu Z,Liu S
Tue Sep 18 00:00:00 EDT 2018
Brg1 aggravates airway inflammation in asthma via inhibition of the PI3K/Akt/mTOR pathway.
Biochemical and biophysical research communications
Zou W,Ding F,Niu C,Fu Z,Liu S
Tue Sep 18 00:00:00 EDT 2018
Brg1 aggravates airway inflammation in asthma via inhibition of the PI3K/Akt/mTOR pathway.
Biochemical and biophysical research communications
Zou W,Ding F,Niu C,Fu Z,Liu S
Tue Sep 18 00:00:00 EDT 2018
Brg1 aggravates airway inflammation in asthma via inhibition of the PI3K/Akt/mTOR pathway.
Biochemical and biophysical research communications
Zou W,Ding F,Niu C,Fu Z,Liu S
Tue Sep 18 00:00:00 EDT 2018
Apatinib promotes apoptosis of the SMMC-7721 hepatocellular carcinoma cell line via the PI3K/Akt pathway.
Oncology letters
Zhang H,Cao Y,Chen Y,Li G,Yu H
Sun Apr 01 00:00:00 EDT 2018
Apatinib promotes apoptosis of the SMMC-7721 hepatocellular carcinoma cell line via the PI3K/Akt pathway.
Oncology letters
Zhang H,Cao Y,Chen Y,Li G,Yu H
Sun Apr 01 00:00:00 EDT 2018
Salidroside mediates apoptosis and autophagy inhibition in concanavalin A-induced liver injury.
Experimental and therapeutic medicine
Feng J,Niu P,Chen K,Wu L,Liu T,Xu S,Li J,Li S,Wang W,Lu X,Yu Q,Liu N,Xu L,Wang F,Dai W,Xia Y,Fan X,Guo C
Fri Jun 01 00:00:00 EDT 2018
Salidroside mediates apoptosis and autophagy inhibition in concanavalin A-induced liver injury.
Experimental and therapeutic medicine
Feng J,Niu P,Chen K,Wu L,Liu T,Xu S,Li J,Li S,Wang W,Lu X,Yu Q,Liu N,Xu L,Wang F,Dai W,Xia Y,Fan X,Guo C
Fri Jun 01 00:00:00 EDT 2018
Salidroside mediates apoptosis and autophagy inhibition in concanavalin A-induced liver injury.
Experimental and therapeutic medicine
Feng J,Niu P,Chen K,Wu L,Liu T,Xu S,Li J,Li S,Wang W,Lu X,Yu Q,Liu N,Xu L,Wang F,Dai W,Xia Y,Fan X,Guo C
Fri Jun 01 00:00:00 EDT 2018
Salidroside mediates apoptosis and autophagy inhibition in concanavalin A-induced liver injury.
Experimental and therapeutic medicine
Feng J,Niu P,Chen K,Wu L,Liu T,Xu S,Li J,Li S,Wang W,Lu X,Yu Q,Liu N,Xu L,Wang F,Dai W,Xia Y,Fan X,Guo C
Fri Jun 01 00:00:00 EDT 2018
LP1 from Lentinula edodes C91-3 Induces Autophagy, Apoptosis and Reduces Metastasis in Human Gastric Cancer Cell Line SGC-7901.
International journal of molecular sciences
Batool S,Joseph TP,Hussain M,Vuai MS,Khinsar KH,Din SRU,Padhiar AA,Zhong M,Ning A,Zhang W,Cao J,Huang M
Sun Sep 30 00:00:00 EDT 2018
LP1 from Lentinula edodes C91-3 Induces Autophagy, Apoptosis and Reduces Metastasis in Human Gastric Cancer Cell Line SGC-7901.
International journal of molecular sciences
Batool S,Joseph TP,Hussain M,Vuai MS,Khinsar KH,Din SRU,Padhiar AA,Zhong M,Ning A,Zhang W,Cao J,Huang M
Sun Sep 30 00:00:00 EDT 2018
Long Non-Coding RNA HOXA-AS2 Regulates Malignant Glioma Behaviors and Vasculogenic Mimicry Formation via the MiR-373/EGFR Axis.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Gao Y,Yu H,Liu Y,Liu X,Zheng J,Ma J,Gong W,Chen J,Zhao L,Tian Y,Xue Y
Fri Mar 16 00:00:00 EDT 2018
Long Non-Coding RNA HOXA-AS2 Regulates Malignant Glioma Behaviors and Vasculogenic Mimicry Formation via the MiR-373/EGFR Axis.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Gao Y,Yu H,Liu Y,Liu X,Zheng J,Ma J,Gong W,Chen J,Zhao L,Tian Y,Xue Y
Fri Mar 16 00:00:00 EDT 2018
lncRNA DLEU1 contributes to tumorigenesis and development of endometrial carcinoma by targeting mTOR.
Molecular carcinogenesis
Du Y,Wang L,Chen S,Liu Y,Zhao Y
Sat Sep 01 00:00:00 EDT 2018
hPMSC transplantation restoring ovarian function in premature ovarian failure mice is associated with change of Th17/Tc17 and Th17/Treg cell ratios through the PI3K/Akt signal pathway.
Stem cell research & therapy
Yin N,Wang Y,Lu X,Liu R,Zhang L,Zhao W,Yuan W,Luo Q,Wu H,Luan X,Zhang H
Wed Feb 14 00:00:00 EST 2018
hPMSC transplantation restoring ovarian function in premature ovarian failure mice is associated with change of Th17/Tc17 and Th17/Treg cell ratios through the PI3K/Akt signal pathway.
Stem cell research & therapy
Yin N,Wang Y,Lu X,Liu R,Zhang L,Zhao W,Yuan W,Luo Q,Wu H,Luan X,Zhang H
Wed Feb 14 00:00:00 EST 2018
Pretreatment with propylene glycol alginate sodium sulfate ameliorated concanavalin A-induced liver injury by regulating the PI3K/Akt pathway in mice.
Life sciences
Xu S,Wu L,Zhang Q,Feng J,Li S,Li J,Liu T,Mo W,Wang W,Lu X,Yu Q,Chen K,Xia Y,Lu J,Xu L,Zhou Y,Fan X,Guo C
Fri Sep 15 00:00:00 EDT 2017
Pretreatment with propylene glycol alginate sodium sulfate ameliorated concanavalin A-induced liver injury by regulating the PI3K/Akt pathway in mice.
Life sciences
Xu S,Wu L,Zhang Q,Feng J,Li S,Li J,Liu T,Mo W,Wang W,Lu X,Yu Q,Chen K,Xia Y,Lu J,Xu L,Zhou Y,Fan X,Guo C
Fri Sep 15 00:00:00 EDT 2017
Pretreatment with propylene glycol alginate sodium sulfate ameliorated concanavalin A-induced liver injury by regulating the PI3K/Akt pathway in mice.
Life sciences
Xu S,Wu L,Zhang Q,Feng J,Li S,Li J,Liu T,Mo W,Wang W,Lu X,Yu Q,Chen K,Xia Y,Lu J,Xu L,Zhou Y,Fan X,Guo C
Fri Sep 15 00:00:00 EDT 2017
Pretreatment with propylene glycol alginate sodium sulfate ameliorated concanavalin A-induced liver injury by regulating the PI3K/Akt pathway in mice.
Life sciences
Xu S,Wu L,Zhang Q,Feng J,Li S,Li J,Liu T,Mo W,Wang W,Lu X,Yu Q,Chen K,Xia Y,Lu J,Xu L,Zhou Y,Fan X,Guo C
Fri Sep 15 00:00:00 EDT 2017
Combination of Endothelial-Monocyte-Activating Polypeptide-II with Temozolomide Suppress Malignant Biological Behaviors of Human Glioblastoma Stem Cells via miR-590-3p/MACC1 Inhibiting PI3K/AKT/mTOR Signal Pathway.
Frontiers in molecular neuroscience
Zhou W,Liu L,Xue Y,Zheng J,Liu X,Ma J,Li Z,Liu Y
Thu Oct 01 00:00:00 EDT 2020
Combination of Endothelial-Monocyte-Activating Polypeptide-II with Temozolomide Suppress Malignant Biological Behaviors of Human Glioblastoma Stem Cells via miR-590-3p/MACC1 Inhibiting PI3K/AKT/mTOR Signal Pathway.
Frontiers in molecular neuroscience
Zhou W,Liu L,Xue Y,Zheng J,Liu X,Ma J,Li Z,Liu Y
Thu Oct 01 00:00:00 EDT 2020
LncRNA MEG3 inhibit endometrial carcinoma tumorigenesis and progression through PI3K pathway.
Apoptosis : an international journal on programmed cell death
Sun KX,Wu DD,Chen S,Zhao Y,Zong ZH
Fri Dec 01 00:00:00 EST 2017
LncRNA MEG3 inhibit endometrial carcinoma tumorigenesis and progression through PI3K pathway.
Apoptosis : an international journal on programmed cell death
Sun KX,Wu DD,Chen S,Zhao Y,Zong ZH
Fri Dec 01 00:00:00 EST 2017
ApoA-I/SR-BI modulates S1P/S1PR2-mediated inflammation through the PI3K/Akt signaling pathway in HUVECs.
Journal of physiology and biochemistry
Ren K,Lu YJ,Mo ZC,-Liu X,Tang ZL,Jiang Y,Peng XS,Li L,Zhang QH,Yi GH
Mon May 01 00:00:00 EDT 2017
ApoA-I/SR-BI modulates S1P/S1PR2-mediated inflammation through the PI3K/Akt signaling pathway in HUVECs.
Journal of physiology and biochemistry
Ren K,Lu YJ,Mo ZC,-Liu X,Tang ZL,Jiang Y,Peng XS,Li L,Zhang QH,Yi GH
Mon May 01 00:00:00 EDT 2017
Low-Level Laser Effect on Proliferation, Migration, and Antiapoptosis of Mesenchymal Stem Cells.
Stem cells and development
Yin K,Zhu R,Wang S,Zhao RC
Mon May 15 00:00:00 EDT 2017
Low-Level Laser Effect on Proliferation, Migration, and Antiapoptosis of Mesenchymal Stem Cells.
Stem cells and development
Yin K,Zhu R,Wang S,Zhao RC
Mon May 15 00:00:00 EDT 2017
Curcumin potentiates the potent antitumor activity of ACNU against glioblastoma by suppressing the PI3K/AKT and NF-κB/COX-2 signaling pathways.
OncoTargets and therapy
Zhao J,Zhu J,Lv X,Xing J,Liu S,Chen C,Xu Y
Fri Dec 09 00:00:00 EST 2022
Curcumin potentiates the potent antitumor activity of ACNU against glioblastoma by suppressing the PI3K/AKT and NF-κB/COX-2 signaling pathways.
OncoTargets and therapy
Zhao J,Zhu J,Lv X,Xing J,Liu S,Chen C,Xu Y
Fri Dec 09 00:00:00 EST 2022
Coptisine from Rhizoma Coptidis Suppresses HCT-116 Cells-related Tumor Growth in vitro and in vivo.
Scientific reports
Huang T,Xiao Y,Yi L,Li L,Wang M,Tian C,Ma H,He K,Wang Y,Han B,Ye X,Li X
Mon Feb 06 00:00:00 EST 2017
Coptisine from Rhizoma Coptidis Suppresses HCT-116 Cells-related Tumor Growth in vitro and in vivo.
Scientific reports
Huang T,Xiao Y,Yi L,Li L,Wang M,Tian C,Ma H,He K,Wang Y,Han B,Ye X,Li X
Mon Feb 06 00:00:00 EST 2017
Protective Effects of Dioscin against Lipopolysaccharide-Induced Acute Lung Injury through Inhibition of Oxidative Stress and Inflammation.
Frontiers in pharmacology
Yao H,Sun Y,Song S,Qi Y,Tao X,Xu L,Yin L,Han X,Xu Y,Li H,Sun H,Peng J
Wed Sep 30 00:00:00 EDT 2020
Protective Effects of Dioscin against Lipopolysaccharide-Induced Acute Lung Injury through Inhibition of Oxidative Stress and Inflammation.
Frontiers in pharmacology
Yao H,Sun Y,Song S,Qi Y,Tao X,Xu L,Yin L,Han X,Xu Y,Li H,Sun H,Peng J
Wed Sep 30 00:00:00 EDT 2020
The transcription factor FOXA1 induces epithelial ovarian cancer tumorigenesis and progression.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
Wang LL,Xiu YL,Chen X,Sun KX,Chen S,Wu DD,Liu BL,Zhao Y
Mon May 01 00:00:00 EDT 2017
The transcription factor FOXA1 induces epithelial ovarian cancer tumorigenesis and progression.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
Wang LL,Xiu YL,Chen X,Sun KX,Chen S,Wu DD,Liu BL,Zhao Y
Mon May 01 00:00:00 EDT 2017
β-Caryophyllene/Hydroxypropyl-β-Cyclodextrin Inclusion Complex Improves Cognitive Deficits in Rats with Vascular Dementia through the Cannabinoid Receptor Type 2 -Mediated Pathway.
Frontiers in pharmacology
Lou J,Teng Z,Zhang L,Yang J,Ma L,Wang F,Tian X,An R,Yang M,Zhang Q,Xu L,Dong Z
Wed Mar 16 00:00:00 EDT 2022
β-Caryophyllene/Hydroxypropyl-β-Cyclodextrin Inclusion Complex Improves Cognitive Deficits in Rats with Vascular Dementia through the Cannabinoid Receptor Type 2 -Mediated Pathway.
Frontiers in pharmacology
Lou J,Teng Z,Zhang L,Yang J,Ma L,Wang F,Tian X,An R,Yang M,Zhang Q,Xu L,Dong Z
Wed Mar 16 00:00:00 EDT 2022
MicroRNA-29a Alleviates Bile Duct Ligation Exacerbation of Hepatic Fibrosis in Mice through Epigenetic Control of Methyltransferases.
International journal of molecular sciences
Yang YL,Wang FS,Li SC,Tiao MM,Huang YH
Wed Jan 18 00:00:00 EST 2017
MicroRNA-29a Alleviates Bile Duct Ligation Exacerbation of Hepatic Fibrosis in Mice through Epigenetic Control of Methyltransferases.
International journal of molecular sciences
Yang YL,Wang FS,Li SC,Tiao MM,Huang YH
Wed Jan 18 00:00:00 EST 2017
Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways.
Scientific reports
Wu L,Zhang Q,Mo W,Feng J,Li S,Li J,Liu T,Xu S,Wang W,Lu X,Yu Q,Chen K,Xia Y,Lu J,Xu L,Zhou Y,Fan X,Guo C
Thu Aug 24 00:00:00 EDT 2017
Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways.
Scientific reports
Wu L,Zhang Q,Mo W,Feng J,Li S,Li J,Liu T,Xu S,Wang W,Lu X,Yu Q,Chen K,Xia Y,Lu J,Xu L,Zhou Y,Fan X,Guo C
Thu Aug 24 00:00:00 EDT 2017
Paper-based microreactor array for rapid screening of cell signaling cascades.
Lab on a chip
Huang CH,Lei KF,Tsang NM
Sun Aug 07 00:00:00 EDT 2016
Paper-based microreactor array for rapid screening of cell signaling cascades.
Lab on a chip
Huang CH,Lei KF,Tsang NM
Sun Aug 07 00:00:00 EDT 2016
DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway.
Medical oncology (Northwood, London, England)
Huang W,Liu J,Feng X,Chen H,Zeng L,Huang G,Liu W,Wang L,Jia W,Chen J,Ren C
Wed Apr 01 00:00:00 EDT 2015
DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway.
Medical oncology (Northwood, London, England)
Huang W,Liu J,Feng X,Chen H,Zeng L,Huang G,Liu W,Wang L,Jia W,Chen J,Ren C
Wed Apr 01 00:00:00 EDT 2015
Effect of baicalin-copper on the induction of apoptosis in human hepatoblastoma cancer HepG2 cells.
Medical oncology (Northwood, London, England)
Li X,Zou K,Gou J,Du Q,Li D,He X,Li Z
Sun Mar 01 00:00:00 EST 2015
Effect of baicalin-copper on the induction of apoptosis in human hepatoblastoma cancer HepG2 cells.
Medical oncology (Northwood, London, England)
Li X,Zou K,Gou J,Du Q,Li D,He X,Li Z
Sun Mar 01 00:00:00 EST 2015
Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-κB and PI3K/Akt3 signaling pathways.
Scientific reports
Liu J,Huang W,Ren C,Wen Q,Liu W,Yang X,Wang L,Zhu B,Zeng L,Feng X,Zhang C,Chen H,Jia W,Zhang L,Xia X,Chen Y
Fri Jul 24 00:00:00 EDT 2015
Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-κB and PI3K/Akt3 signaling pathways.
Scientific reports
Liu J,Huang W,Ren C,Wen Q,Liu W,Yang X,Wang L,Zhu B,Zeng L,Feng X,Zhang C,Chen H,Jia W,Zhang L,Xia X,Chen Y
Fri Jul 24 00:00:00 EDT 2015
Phosphorylation and changes in the distribution of nucleolin promote tumor metastasis via the PI3K/Akt pathway in colorectal carcinoma.
FEBS letters
Wu DM,Zhang P,Liu RY,Sang YX,Zhou C,Xu GC,Yang JL,Tong AP,Wang CT
Wed May 21 00:00:00 EDT 2014
Phosphorylation and changes in the distribution of nucleolin promote tumor metastasis via the PI3K/Akt pathway in colorectal carcinoma.
FEBS letters
Wu DM,Zhang P,Liu RY,Sang YX,Zhou C,Xu GC,Yang JL,Tong AP,Wang CT
Wed May 21 00:00:00 EDT 2014